Main Sequence

Frontier Dispatch: Deep Tech Conversations

Business EN ↓ 4 episodes

Frontier Dispatch is a podcast from Main Sequence about the people rebuilding the world's most essential systems. Every episode is a conversation from inside the work, with the founders, investors, researchers, and builders who have chosen problems that are too important to leave unsolved. Energy. Food. Health. Space. Compute. Defence. The systems the future depends on. This is a show about what it actually takes to build at the frontier, the timelines, the capital intensity, the moments where the science finally becomes possible, and the conviction required to stay when it gets hard. Hosted b...

Author

Main Sequence

Episodes

Field Work: Making the Old New Again | Michele Stansfield 14.04.2026 18:14

The conversation delves into the challenges and innovations in precision fermentation, marketing deep tech, and the transition from batch to continuous fermentation. It explores the need for tech demonstration, scaling, and the deployment of new technology in the industry. Hosted by Jason Whitfield.

Long Position: Capital Flows and Conviction | Brighid Pappin 14.04.2026 11:00

Brighid discusses the changes in investment conviction over the last 12-24 months, emphasizing the importance of value creation, manager synergy, and track record. She also highlights the need to cut through the noise in deep tech and the potential gaps in the capital funnel. Hosted by Elaine Stead

Field Work: The Next Horizon of Humanity Scale Healthcare Impact | Xoma, Xylo, and Currus Biologics 14.04.2026 21:20

The conversation covers the development of novel neurotherapeutics by Xylo, the motivation and impact behind the work, Xylo's unfair advantage, Zoma Labs' continuous glucose monitoring, their unfair advantage, and Currus Biologics' cell therapy for solid tumors. Hosted by Elaine Stead.

Sharp End: "I thought I understood Amazon's 'Build Backwards' method, until I met Steve Kessel" 14.04.2026 26:56

The conversation with Steve Kessel from Amazon focused on the importance of emphasizing people and processes over brute force, leadership through people and processes, and the significance of the PR FAQ process in product development. The discussion also covered the hiring for superpowers, building momentum and iteration, and the role of leadership in making judgment calls. Hosted by Phil Morle. T...