#ExpertAnswers - an InsideScientific Podcast

Marcel Perret-Gentil presents six simple-to-implement techniques to significantly improve surgical outcomes, to lessen post-op mortality and improve data yield after surgery.

Davide Boido and Antoine Bergel discuss their work on how state-of-the-art multimodal neuroimaging can be coupled with functional ultrasound to study neurovascular coupling across vigilance states.

Jastyn A. Pöpplau and Marilena Hnida discuss their research on prefrontal networks in developing head-fixed mice, and the role of these networks in cognition and models of neurodevelopmental diseases. 

Artur Fedorowski explains CV dysautonomia as a specific sequalae of acute COVID-19 and guides the audience in the diagnostic work-up of PASC patients with suspected cardiovascular complications.

Connar Westgate discusses his research involving intracranial pressure measurements and the importance of understanding this physiological parameter for maintaining normal central nervous system function.

Audrey Dubourg and Gareth Guenigault from CN Bio discuss the value that an organ-on-a-chip approach can bring to drug discovery and development workflows, and how the regulatory landscape is shifting to encourage their widespread adoption.

Sarah Greising discusses the current pathophysiologic understanding of the skeletal muscle remaining following traumatic musculoskeletal injuries.

Marrit Putker, Saskia De Man, and Pirouz Daftarian from Crown Bioscience discuss T cell-directed immunotherapy on the cancer-immunity cycle, including mechanisms and targets capable of modulating and enhancing T cell activity and the application of methods and models including organoids and high content imaging.

Dudley Lamming, PhD, explains that “We Are More Than What We Eat”; Sex and Genetic background are important factors in observing responses to diet in mice.

Phil Griffiths draws from his experience as a telemetry user to discuss some important considerations for designing telemetry studies.

Cole McLarty, Nick Glover and Dr. Timothy Hacker focus on Pressure-Volume Loop collection and data analysis for cardiovascular research.

Dennis Turner delves into dementia syndrome, the metabolic changes that occur, and the importance of proper physiological monitoring of animal models.

Rajendra Kumari and Gera Goverse provide an overview of the cancer immunity cycle and present several methods, techniques, and model systems for immuno-oncology research.

Oscar Perez Leal and Jon Weidanz discuss the basis of the FAST-HDR gene-editing system to create custom cell lines, and present case studies highlighting several applications.

Amy Sheng provides an overview of antibody screening platforms and presents applications and case studies using the Beacon® platform for antibody discovery.

Ejvind Mørtz discusses the benefits and applications of mass spectrometry (MS)-based host cell protein (HCP) analysis and why HCP ELISAs are insufficient for documenting product-related impurities.

Andrew Taylor provides an overview of processes by which drugs are metabolized and talks about the importance of drug metabolism and drug-drug interaction studies.

Giacomo Rossitto answers questions from a recent webinar where he shares his research on heart failure and the related lymphatic dysfunction in patients.

Jonathan Brestoff explains how energy expenditure can be better described thanks to a new bioinformatic algorithm known as Clambake.

Michael Sturek reviews features of macrovascular atherosclerosis and microvascular dysfunction that underlie ischemic events and the need for appropriate animal models for optimal translation.

David Barefield discusses his work investigating the role of the Myosin binding protein H-like (MyBP-HL) protein in atrial dysfunction.

Eduardo Marbán dives into the complexities of regenerative cardiovascular medicine and the future directions for cell therapies.

Jason Rogers and Eliala Salvadori answer questions from a recent webinar that discussed research involving infant emotional communication patterns and coded behaviors.

Bradley Palmer answers questions from a recent webinar where he highlighted and demonstrated the challenging preparation of cardiac tissue slices and measurement of force and calcium.

Adrián Rodríguez-Contreras and Barbara Lind discuss their work on neurovascular coupling in awake head-fixed and anesthetized mice, with a focus on the effects of anesthetics.