John Shufeldt, MD, JD, MBA, FACEP

Entrepreneur Rx

Business EN ↓ 90 episodes

What does it take to build something that matters? Hosted by John Shufeldt, Entrepreneur Rx features conversations with founders, investors, executives, and innovators who are building the future. From entrepreneurship and venture capital to technology, healthcare, defense, and leadership, each episode explores the stories, challenges, and lessons behind creating impactful companies and driving meaningful change. Learn more at www. XcellerantVentures.com

Author

John Shufeldt, MD, JD, MBA, FACEP

Category

Business

Podcast website

www.johnshufeldtmd.com

Latest episode

Jul 7, 2026

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Episodes

Marissa Fayer: Advancing AI, Medical Imaging, and the Future of Women’s Health 07.07.2026

What does it take to turn decades of healthcare experience into technology that could help improve cancer detection and patient care? In this episode of Entrepreneur Rx, host John Shufeldt sits down with Marissa Fayer, CEO of DeepLook Medical, to discuss her journey from corporate medtech executive to entrepreneur, investor, nonprofit founder, and women’s health advocate. Marissa shares how her ba...

Visar Berisha: Proving What’s Real in the Age of Deepfakes 30.06.2026

How do you prove that the person speaking to you is actually human?  In this episode of Entrepreneur Rx, host John Shufeldt sits down with Visar Berisha, founder and CEO of OriginStory, to explore one of the most urgent problems emerging in the age of artificial intelligence: how to verify reality when voice, video, and identity can be convincingly replicated.  Visar shares how today’s AI tools ca...

Nishant Doctor: Reimagining Autoimmune Treatment Through Ultrasound Neuromodulation 23.06.2026

What if autoimmune disease could be treated without another injection, infusion, or daily pill?  In this episode of Entrepreneur Rx, host John Shufeldt sits down with Nishant Doctor, founder and CEO of Surf Therapeutics, to discuss his journey from medtech engineer to healthcare entrepreneur. Nishant shares how nearly two decades in neuromodulation, R&D, clinical development, and commercializa...

Dom Messerli: Reinventing Spine Surgery with Lenoss Medical 16.06.2026

What does it take to challenge decades of conventional medical practice?  In this episode of Entrepreneur Rx, host John Shufeldt sits down with Dom Messerli, founder and CEO of Lenoss Medical, to discuss his journey from medical device executive to entrepreneur. Dom shares how listening to surgeons led him to develop a biological alternative to traditional bone cement used in spinal fracture proce...

Allisa Song: From Medical Student to CEO of MU Medical 09.06.2026

In this episode of Entrepreneur Rx, John sits down with Allisa Song, Co-Founder and CEO of MU Medical. Allisa shares the story behind developing NanoDropper, a device designed to reduce medication waste and improve patient adherence, as well as her entrepreneurial journey. They discuss the realities of building healthcare companies, navigating the challenges of entrepreneurship, and bringing innov...

Entrepreneur Rx Interview with Courtney Williams, Co-founder and CEO of Emagine Solutions Technology 07.02.2024

For episode 85 of Entrepreneur Rx, John welcomes Courtney Williams, co-founder and CEO of Emagine Solutions Technology. Emagine is tackling the U.S. maternal health crisis with remote patient monitoring. The podcast starts off with Courtney touching on her diverse background and then she moves to how her sister’s high-risk pregnancy inspired her to get into healthcare entrepreneurship. This experi...

Entrepreneur Rx Interview with Dom Messerli, Founder, President and CEO of Lenoss Medical 25.01.2024

For this episode of Entrepreneur Rx, John sits down with Dom Messerli, the President and CEO of Lenoss Medical. Lenoss Medical is disrupting the treatment of spinal fractures with their OsteoPearl Vertebral Body Augmentation (VBA) System. This minimally invasive and epoxy-free technology delivers a fully biological solution to stabilize spinal fractures and utilizes the natural healing properties...

Entrepreneur Rx Interview with Ross Bundy, Founder and CEO of CRISPR QC 08.01.2024

For episode 83 of Entrepreneur Rx, John welcomes Ross Bundy, CEO of CRISPR QC. CRISPR QC is a biotechnology company aimed to equip scientists and researchers with data to improve their CRISPR assay design by using its sensor technology to analyze gene editing processes.   Ross starts off the episode by discussing his background in gene therapy and his experience founding Cardea Bio. He also talks...

Entrepreneur Rx Interview with Hillary Lin, Co-Founder and CEO of Curio 13.12.2023

Internal medicine physician Hillary Lin is the co-founder and CEO of Curio, a VC-backed healthcare startup that is reshaping the landscape of cancer care with hands-on, personalized solutions driven by the power of AI.   As a Taiwanese immigrant, she experienced firsthand the stark contrast between the complicated healthcare system in the United States and the simplicity of a universal healthcare...

Entrepreneur Rx Interview with James (Jim) Dahle, Founder of The White Coat Investor 15.11.2023

For episode 81 of Entrepreneur Rx, John had the pleasure of sitting down with fellow emergency medicine physician James (Jim) Dahle, founder of The White Coat Investor. The White Coat Investor is the most widely read, physician-specific personal finance and investing website in the world. In addition to the blog, he has authored four books and hosts two weekly podcasts. Jim shares his journey to f...

Entrepreneur Rx interview with John Criswell, Founder, Chairman and CEO of Porter 01.11.2023

For episode 80 of Entrepreneur Rx, John welcomes back John Criswell, founder, chairman, and CEO of Porter, a transformative healthcare solution that aims to improve the home healthcare journey for payers and their vulnerable members. John Shufeldt’s venture capital firm, Xcellerant Ventures, also recently invested in Porter. Porter utilizes AI-derived insights and a dedicated clinical team, along...

Entrepreneur Rx: Interview with Esther Dyson, Founder of Wellville 18.10.2023

For episode 79 of Entrepreneur Rx, John interviews rockstar Esther Dyson, founder of Wellville, a 10-year nonprofit project dedicated to demonstrating the value of long-term investment in health and equity. Esther has been or is a director of many companies such as 23andMe, Avanlee Care, Meetup, and WPP Group. In addition, Esther is an active angel investor and also enjoys sitting on the boards of...

Entrepreneur Rx: Interview with Alan Roga, Founder and CEO of TruLite Health 04.10.2023

For episode 78 of Entrepreneur Rx, John Shufeldt interviews fellow ER doc and seasoned healthtech entrepreneur Alan Roga, CEO and Co-Founder of TruLite Health. TruLite Health’s platform Truity™ is the markets first comprehensive health equity platform and brings together the largest proprietary clinical health equity knowledge base and recommendations with patient-specific clinical and social data...

Entrepreneur Rx: Interview with James Bates, Founder and CEO of AdviNOW 20.09.2023

For episode 77 of Entrepreneur Rx, John Shufeldt interviews long-time friend James Bates. James is the CEO and founder of AdviNOW Medical, the world's first artificial intelligence and augmented reality driven patient journey platform that nearly eliminates the administrative burden for physicians and reduces the cost of healthcare. In this interview, James shares his personal drive to always...

Entrepreneur Rx: Interview with Dr. Lyle Berkowitz, Founder and CEO of KeyCare 06.09.2023

For episode 76 of Entrepreneur Rx, Dr. John Shufeldt spoke with fellow physician entrepreneur, Dr. Lyle Berkowitz. Dr. Lyle is the founder and CEO of KeyCare, the nation’s only Epic-based virtual care company, whose mission is to help health systems expand their capacity by giving them access to their tech-empowered virtual care workforce. Dr. Lyle has a unique background as an engineer who became...

Entrepreneur Rx: Interview with Ed Connors, Founder of Heudia Health 23.08.2023

On this episode of Entrepreneur Rx, host John Shufeldt interviews Ed Connors, a serial entrepreneur with a diverse background in engineering, aviation, and electronics. Ed has been in the healthcare and public health space for the last 25 years, focusing on addressing health disparities and improving access to care. He is currently the founder of Heudia Health which has created a platform called A...

Entrepreneur Rx: Interview with Stanley T Lewis, MD, MPH, Founder and CEO of A28 Therapeutics 09.08.2023

On Episode 74 of Entrepreneur Rx, Dr. John Shufeldt sat down with Dr. Stanley Lewis, an internal medicine physician, serial entrepreneur, and philanthropist. Stanley’s most recent endeavor is being the founder and CEO of A28 Therapeutics. Stanley has a diverse background, starting with his medical training at the University of Texas McGovern School of Medicine and his work in patient care, educati...

RX73: Entrepreneur Rx Interview with Subha Airan-Javia MD, FAMIA, CEO & Founder at CareAlign 28.06.2023

Welcome back to another episode of Entrepreneur Rx! This week, John discusses with Dr. Subha Airan-Javia her entrepreneurial journey, the influence of AI in healthcare, challenges in technology transfers and commercialization,  and the development CareAlign, a platform designed to improve healthcare efficiency and patient care with a web-based solution for task management, communication, and acces...

RX72: Entrepreneur Rx Interview with Darren Sommer, DO, MBA, MPH, CEO at Innovator Health 14.06.2023

Welcome back to another episode of Entrepreneur Rx! This week, John talks with Darren Sommer about Sommer’s journey in healthcare and the military, his experience working in Afghanistan, and how he transitioned into becoming an entrepreneur with Innovator Health. He explains how Innovator Health started focusing on telemedicine and provides hospital medicine services, which has been successful due...

RX71: Entrepreneur Rx Interview with Ayushi Patel, Co-Founder and CEO at CenSyn 31.05.2023

Welcome back to another episode of Entrepreneur Rx! This week, John talks to Ayushi Patel, Co-Founder and CEO at CenSyn, about how the PenEEG will improve protocols after head injuries and make neurology accessible outside hospitals. Brain health screenings can take from 4 to 48 hours in Emergency Departments and ICUs, even though they should be handled with extreme caution from the moment an inju...

RX70: Entrepreneur Rx Interview with Elsa Chi Abruzzo, RAC, FRAPS, CEO & President of Anuncia Medical 17.05.2023

Welcome back to another episode of Entrepreneur Rx! This week, John interviews Elsa Chi Abruzzo about Anuncia Medical’s recent product, the ReFlow Ventricular System, a device that can improve the lives of Hydrocephalus shunt patients. She also provides great advice for medical device entrepreneurs looking to develop and scale their own solutions. Listen to this episode and learn about this disrup...

RX69: Entrepreneur Rx Interview with Harvey Castro, MD, MBA, FACEP, Author of ChatGPT Healthcare 03.05.2023

Welcome back to another episode of Entrepreneur Rx! This week, John has a conversation with Harvey Castro, emergency medicine physician and multidisciplinary serial entrepreneur, about his medical career with innovation and technology and the topics he touches on in his books.  Tune in to learn more about venturing into digital health and how ChatGPT might play into that space in the future!

RX68: Entrepreneur Rx Interview with Andrew Heuerman, Founder & CEO at The Patient Company 19.04.2023

Welcome back to another episode of Entrepreneur Rx! This week, Andrew Heuerman, founder and CEO of The Patient Company, talks about the development and commercialization of their first product, explaining the troubles of bringing providers’ ideas to fruition, and the process the company has been following to test and improve SimPull. Tune in to learn about developing an innovative idea into a prod...

RX67: Entrepreneur Rx Interview with Matt Lashey, CEO of Treatment Technologies & Insights 05.04.2023

Welcome back to another episode of Entrepreneur Rx! This week on the podcast, John has an insightful talk with Matt Lashey, Co-Founder and CEO of Treatment Technologies & Insights and Creator of chemoWave and Wave Health. Treatment, Technologies & Insights is a health technology company with a portal that provides insight for physicians to receive reports and data on their patients, while...

RX66: Entrepreneur Rx Interview with Casey Grage, Founder & CEO at Hubly Surgical 22.03.2023

Welcome back to another episode of Entrepreneur Rx! This week, John interviews Casey Grage, founder, and CEO of Hubly Surgical, a company that developed a medical single-use electric cranial drill that monitors resistance to ensure a safe autostop before hitting brain tissue, reducing error margins, costs, and operating room dependence. Drilling a hole into the skull is the most common neurosurgic...

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