Endgame with Amanda Cassatt

Andrew Keys found Ethereum before it launched, when ETH was around 30 cents. Eleven years later, he’s betting on a very different layer of the technology stack: AI infrastructure.  In Ohio, a former paper mill is being repurposed for AI compute. Keys says the first transaction represents roughly 10,000 GPUs, while Alignment Engine has disclosed $1.17 billion in four-year AI infrastructure orders....

“Thanks very much for several dozen pages of legally void correspondence. It will make excellent bedding for my pet hamster.” That’s how Preston Byrne, the lawyer representing 4chan, responded to Britain’s internet regulator, Ofcom. The dispute began after Ofcom targeted 4chan under the UK’s Online Safety Act. The regulator ultimately imposed £520,000 in additional penalties in March 2026, followi...

Malcolm and Simone Collins became known as prominent voices in the pronatalist movement. But today, much of their work is focused on a different question: what happens to humans, culture, education, and future generations as artificial intelligence transforms society? In this episode of Endgame, Amanda Cassatt sits down with Malcolm and Simone to explore how AI is reshaping internet culture, why t...

Santiago R. Santos of Inversion was investing in DeFi before “DeFi” was even a widely used term. As a former partner at ParaFi and an early investor in projects including Aave, Arbitrum, and Polymarket, he watched Ethereum evolve from an experimental smart contract platform into the foundation of a massive onchain economy. But the growth of crypto has also changed his investment thesis. In this ep...

What if we could select the optimal genetic traits for our children? In this episode of Endgame, Amanda Cassatt sits down with bioethicist and philosopher Jonathan Anomaly to explore the cutting edge of reproductive biotechnology. They dismantle the social and political taboos surrounding genetic curation, tracing everything from the uncomfortable reality of cognitive capacities and human success...

Corporate metaverses failed the moment big tech tried to turn human connection into a closed retail space. In this episode of Endgame, Second Life creator Philip Rosedale joins Amanda Cassatt to explain why corporate giants spent $80 billion and still couldn't build a functional virtual world. Moving far beyond the surface-level hype of Silicon Valley, Philip exposes how algorithmic feeds and...

As chief cryptographer of Sui and Mysten Labs, Kostas Chalkias helped design a blockchain built on more than 100 published cryptography papers and an object-based architecture fast enough to let AI agents chain dozens of transactions into a single intent, without skipping the security research most "fast chains" leave out entirely. In this episode of Endgame, Amanda Cassatt sits down wit...

Diogo Mónica co-founded Anchorage Digital, the first federally chartered crypto bank in the US, and now argues for a position most of Silicon Valley won't say out loud: America should be building closed AI, not open source. In this episode of Endgame, Amanda Cassatt sits down with Diogo, Co-Founder of Anchorage Digital and General Partner at Haun Ventures, to break down why he thinks open-sour...

Robinhood is evolving far beyond commission-free trading. In this episode of Endgame, Amanda Cassatt sits down with Johann Kerbrat, SVP & GM of Robinhood Crypto, for an in-depth conversation about how Robinhood is using blockchain, AI, and tokenization to reshape investing. Johann explains why Robinhood built its own Layer 2 on Ethereum, how tokenized stocks work in Europe, why Robinhood belie...

In this episode of Endgame, the roles are reversed. Timour Kosters takes the mic to interview Amanda Cassatt. Together they explore why technology can both expand and limit freedom, how smartphones and algorithms shape our choices, why LLMs may homogenize culture and creativity, and what crypto still offers as a hedge against centralized control. They also discuss Bitcoin, Ethereum, stablecoins, f...

How Swift works is one of the most misunderstood topics in crypto payments. Tom Zschach spent six years as Chief Innovation Officer at Swift, and he has unique insights to share. In this episode: Why stablecoins aren’t replacing Swift; they’re connecting to it Why Tom called Ripple a fax machine and stands by it Why a token isn’t money and what that means for settlement Why faster and cheaper isn’...

Adam Back invented the proof-of-work system that became Bitcoin's foundation. The New York Times says he's Satoshi Nakamoto. He says he isn't, but he was the first person Satoshi ever emailed. Every major publication is asking whether quantum computing will break Bitcoin. The consensus is nervous. Adam Back, the man who built Bitcoin's cryptographic foundation, is not. In this conv...

Cultural theorist and essayist Toby Shorin joins Amanda Cassatt to explore one of the most urgent questions of the AI era: What happens to the human body and human meaning when thinking itself becomes commodified? Drawing on his essay “Body Futurism,” Toby argues that we’re witnessing a massive embodied turn in culture, from peptides and biohacking to looks-maxing and sports investment. But the re...

Your identity, your assets, your privacy, do you actually own any of it online?  Binji Pande from the Ethereum Foundation says no. And he's spent his career trying to change that. In this episode, Amanda sits down with Binji to explore why crypto is really about redesigning human incentives, what digital rights actually mean, and what it would take to build a world where freedom online isn&#39...

Everyone in crypto is chasing TPS Eunice Giarta thinks that's the wrong race entirely As co-founder of Monad Foundation, she spent four years building what she calls the Ethereum of high-performance blockchains  a chain with validators on six continents, in 30 countries and 58 cities, that doesn't sacrifice decentralization for speed. In this episode of Endgame, Amanda Cassatt sits down wi...

“A lot of users don’t need a bank. What they need is a wallet.” In this episode of Endgame, Amanda Cassatt sits down with Richard Teng, CEO of Binance, for a conversation about what crypto actually became and whether that’s the right thing. Richard spent three decades in traditional finance, including the Central Bank of Singapore, before joining Binance in 2021. He doesn’t argue like a convert. H...

“The block explorer is your x-ray machine. Open it up, and you find rooms full of people.” In this episode of Endgame, Amanda Cassatt sits down with Austin Federa, former Head of Strategy at Solana and co-founder of DoubleZero, for a rare, candid conversation shaped by shared history on opposite sides of the Ethereum–Solana divide. They unpack the real meaning of decentralization: is it a philosop...

In this episode of Endgame , Amanda Cassatt cuts through the AI hype to explore what happens when creation becomes free. The result isn’t less competition—it’s more noise. She unpacks a web flooded with AI content, misaligned platforms, and the rising value of curation, taste, and real skill. From the future of digital work to the surprising role of crypto—where AI agents, stablecoins, and frictio...

“The scammy elements of crypto are turning people off—and that’s something we need to fix.” In this episode of Endgame, Amanda Cassatt sits down with Yat Siu, co-founder of Animoca Brands, to unpack crypto’s evolution—from idealism to hype cycles—and what comes next. They explore AI agents, the open metaverse, and who actually benefits as technology scales. Yat argues blockchain was built for a fu...

Most of the people running the world are not evil masterminds; they are sincere operators trapped in an “epistemic maze.” In this episode of Endgame, Amanda Cassatt sits down with Curtis Yarvin to explore why the rules-based international order was always fragile and how elite decision-makers operate on unexamined assumptions. They unpack Yarvin’s “interchangeable baby theory,” the 20th-century be...

"If you are using technology to manipulate other people, you should be ashamed of yourself."In this episode of Endgame, Amanda Cassatt sits down with George Hotz to explore when technology empowers and when it traps. Using the framework of finite and infinite games, they define manipulation as placing someone in a system designed to extract from them without their awareness. They examine...

As artificial intelligence agents become the dominant interface to the web, the question is no longer just “Who are you?” but “Who is acting on your behalf?” In this episode of Endgame, Amanda Cassatt sits down with Billions Network CEO Evin McMullen to examine the rapid shift toward agent-mediated internet use. At the end of last year, roughly one in every 31 website visits was conducted by a non...

As artificial intelligence becomes the dominant interface for work, creativity, and competition, some people are adapting to it far faster than others. In this episode of Endgame, Amanda Cassatt sits down with Dragonfly Capital’s Haseeb Qureshi to explore a generational shift in technological advantage: the biggest winners of every major tech transition are not the most experienced, but the most “...

Technology is the most powerful force in history, and whether it liberates or consumes us depends entirely on how aligned it is with human agency. For Amanda Cassatt, this belief underpins her techno-optimism: the conviction that progress must be actively built, not passively awaited. In this solo episode, she explains how she sees technology as upstream of culture, economics, and politics, and vi...

As nation-states double down on borders, nationalism, and readiness for war, some people are choosing not to wait around to see how that ends. Amanda Cassatt sits down with Timour Kosters, who worked alongside Vitalik Buterin on Zuzalu, and co-founder of Edge City, a borderless pop-up society where highly driven builders, thinkers, and creators experiment with life beyond the nation-state. Emergin...