Critically Speaking

What if the biggest risk factor for cancer, heart disease, and dementia isn't your genes, diet, or blood pressure but aging itself? Listen in as biogerontologist Dr. Matt Kaeberlein reveals how understanding the biology of aging could add not just years to our lives, but healthy decades, and why your dog might hold some of the most important clues.   In this episode, Therese Markow and Dr. Matt Ka...

Hidden in your water, food, and even your blood, forever chemicals (PFAS) are nearly impossible to destroy - and now U.S. regulations are being rolled back. Listen in to how PFAS became unavoidable, what they're doing to our health, and whether we can ever truly get rid of them.   In this episode, Therese Markow and Dr. Carrie McDonough discuss perfluoroalkyl substances (PFAS), also known as forev...

Peptides are being sold online as miracle fixes for energy, healing, and longevity—but what if the science behind them is shaky, or even dangerous?    In this episode, Therese Markow and Dr. Leigh Baxt pull back the curtain on the peptide craze, revealing what we really know (and don't know) about these heavily marketed "biohacks." They discuss the complexities and risks of unapproved peptides, wh...

Dr. Kate Mangino exposes the hidden burden of cognitive and emotional labor at home and explains how "benevolent sexism" and unequal household roles quietly push women to the breaking point.   In this episode, Therese Markow and Dr. Kate Mangino discuss gender inequality in household responsibilities. Kate differentiates between structural and social inequalities, noting that societal norms perpet...

Our cities are anything but concrete jungles. Listen in as Therese Markow and Dr. Dan Werb reveal the hidden world of synanthropes - the wild animals that not only live alongside us, but thrive because of us. In this episode, Therese Markow and Dr. Dan Werb discuss Dan's new book "Our Wild Familiars", which explores how animals (and plants) adapt to urban environments. They dive into the history a...

In this episode, Therese Markow and Dr. Boris Konrad discuss the striking impact of memorization on functional changes and connectivity in the brain. Dr. Konrad is a neuroscientist as well as an international Memory Champion. He not only studies brain connectivity, but also trains other memory athletes, as well as those who simply wish to improve their memories. They discuss more specific aspects...

Long COVID isn't just lingering fatigue. It's a complex, often life-altering condition that can follow even mild or unnoticed infections. Listen in as Mayo Clinic's Dr. Stephanie Grach breaks down what we really know about Long COVID, who's at risk, and why believing and individualizing care for patients is absolutely critical.   In this episode, Therese Markow and Dr. Stephanie Grach discuss the...

How does ChatGPT affect your ability to learn, recall, and share information?   In this episode, Therese Markow and Natalie Wexler discuss the impact of generative AI (like ChatGPT) on education. They discuss the change in writing skills, how AI can undermine the learning process that comes with writing, and the incorrect information often provided by generative AI. Natalie explains how AI can fun...

Ru Marshall pulls back the curtain on the man behind the myth of Carlos Castaneda, exposing the real lives, lies, and losses buried beneath his legendary books. In this episode, Therese Markow and Ru Marshall discuss the life and legacy of Carlos Castaneda, who claimed to have been trained as a shaman by Don Juan. Castaneda's books, which sold over 8 million copies, were initially believed but lat...

In this episode, Therese Markow and Patrick Wyman discuss Patrick's latest book, Lost Worlds: How Humans Tried, Failed, Succeeded, and Built Our World. Patrick also discusses his journey as a historian from studying the Fall of Rome to popular history. He emphasizes the importance of understanding past climactic changes and their impact on human societies, including the development of agriculture...

When a globally respected infectious disease expert is abruptly sidelined by an anti‑vaccine administration, what does it reveal about the future of public health and scientific integrity?   In this episode, Therese Markow and Dr. Jeanne Marrazzo discuss her termination and whistleblower lawsuit against the U.S. government. She highlighted NIAID's critical role in infectious disease research, fund...

In this episode, Therese Markow and Dr. Chelsea Polis discuss the evolution of reproductive rights in the U.S., highlighting the 2022 Supreme Court decision revoking the right to abortion and the historical context of contraception access. Dr. Polis also explains fertility awareness-based methods (FABMs) and their effectiveness, noting that some methods have moderate quality studies suggesting hig...

In this episode, Therese Markow and Dr. Keith McCormick discuss what you need to know about osteoporosis and bone health. Dr. McCormick explains what causes osteoporosis, the importance of early bone density tests, and breaks down some of the lifestyle factors that affect bone health. They discuss the need for personalized treatment beyond only medication, and Dr. McCormick advocates for patient e...

In this episode, Therese Markow and Dr. Dawn Sarno, a leading expert on cyber scams, discuss the prevalence and detection of phishing scams. Dawn explains that phishing often targets older adults due to their perceived lack of tech savvy and higher financial stakes, but notes that younger adults are also vulnerable, often due to impulsivity and poor online habits. She highlights the rise of AI-gen...

In this episode, Therese Markow and Dr. Daniel Buchman discuss chronic pain, affecting over 20% of the population in the US, Canada, and Europe. Chronic pain (persisting pain lasting over three months) includes conditions like arthritis, lower back pain, fibromyalgia, and phantom limb pain, among many others. Daniel highlights the challenges in pain assessment, the role of AI in pain management, a...

In this episode, Therese Markow and Dr. David Hill discuss the rise of peanut allergies in children. David explains that anaphylaxis, a severe allergic reaction, is common in children, often triggered by food. He emphasizes the importance of early allergen introduction to prevent allergies. The LEAP study from 2015 showed that introducing peanuts before six months reduces the risk of peanut allerg...

In this episode, Therese Markow and Dr. Fred Miller discuss the autoimmune disease epidemic, highlighting the economic burden and the rise of diseases like juvenile diabetes, lupus, and multiple sclerosis. Dr. Miller explains that autoimmune diseases occur when the immune system attacks the body, affecting various organs. He notes that there are at least 150 types of autoimmune diseases, with prev...

In this episode, Therese Markow and Dr. John Kisiel discuss early cancer detection using liquid biopsies. Dr. Kisiel explains that liquid biopsies detect cancer signals in blood and urine, including tumor cells, fragments, proteins, and DNA. He highlights the FDA's approval of a blood test for colon cancer and the development of multi-cancer early detection tests. Dr. Kisiel notes that false posit...

Some people live more than a hundred years with no health problems and very little cognitive decline.  How come?  While healthy lifestyles certainly play a part in healthy aging, these "centenarians" share a number of special biological attributes.  Furthermore, these attributes, along with attaining an age of 100 or greater, show a strong genetic component.  Dr. Stacy Andersen of the Boston Unive...

In this episode, Therese Markow and Dr. Kari Nadeau discuss the presence and health effects of microplastics in our bodies. Microplastics can enter our bodies through various environmental routes, including food, water, and air. They are in everyone's bodies to some degree.  Microplastics have been linked to health issues like stroke, cancer, and heart attacks. Simple actions like avoiding single-...

In this episode, Therese Markow and Dr. Lise Eliot discuss neurosexism and brain differences between males and females. Dr. Eliot explains that historical brain comparisons often aimed to prove women's inferiority, citing examples like weighing cadaver brains. Modern MRI studies show minor structural differences, but still present significant methodological challenges. She highlights that brain pl...

In this episode, Therese Markow, Dr. Catherine Lebel, and Dr. Sam Nivins discuss the impact of prenatal factors on fetal brain development. Catherine explains how MRI can detect subtle brain changes due to prenatal alcohol exposure, even at low levels, and emphasizes the importance of avoiding alcohol during pregnancy. Sam discusses the effects of maternal obesity before pregnancy on brain develop...

In this episode, Therese Markow and Dorothy Roberts discuss her book "The Mixed Marriage Project," which explores her father's unpublished research on mixed marriages in Chicago. Dorothy's father, a white anthropology professor, interviewed over 500 black-white couples from the 1930s to the 1960s. The book blends personal stories, historical insights, and interviews, revealing the challenges and d...

In this episode, Therese Markow and Dr. Tami Rowen discuss the listener questions that arose from her last episode on Critically Speaking. From drinking soy milk as a substitute for estrogen, the complex relationship between the number of children you have and breast cancer risk, dense breast tissue, early menstruation, hormone replacement therapy, and more. Listen in for the answers to your quest...

In this episode, Therese Markow and Dr. Haley Hersant discuss a study by Dr. Hersant and her colleagues that reviewed over 100 brain and memory supplements. They found 18 common ingredients grouped into three categories: those with scientific evidence of benefit, those with no compelling evidence, and those with mixed results. They discuss the results of this study and emphasize the need for more...