Brain Matters (Video)

Alzheimer’s disease unfolds over many years through a complex interplay of amyloid, tau, genetics, lipid biology, and the brain’s immune response. John Hardy, Ph. D., explains how rare inherited forms of Alzheimer’s disease helped shape current thinking about how the disease begins, then connects those discoveries to broader questions about late onset disease and why it develops differently across...

How fast are you really aging, and what could that mean for brain health? Aladdin H. Shadyab, Ph. D., explores the gap between chronological age and biological age, and why that difference matters for long-term health. Shadyab describes tools that use information from blood to estimate how quickly the body is aging, including approaches that look beyond the body as a whole to consider aging in spe...

Sarah Banks, Ph. D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlo...

Martin Kampmann, Ph. D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochon...

What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph. D., a leading expert in healthy aging, dementia, and Alzheimer's disease, as she discusses the latest research on the effects of exercise on brain health. Stay informed and proactive about maintaining cognitive function as you age with insights from cutting-edge research. Series: "Stein Institute for Research on...

What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph. D., a leading expert in healthy aging, dementia, and Alzheimer's disease, and discover actionable steps you can take to protect your brain health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40061]

What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph. D., a leading expert in healthy aging, dementia, and Alzheimer's disease, as she discusses the latest research on diet and cognitive decline. Learn how diet, vascular health and inflammation contributes to cognitive function and discover actionable steps you can take to protect your brain health. Stay informed an...

What can you do today to improve or maintain your brain health? Sarah Banks, Ph. D., an expert in healthy aging, dementia, and Alzheimer's disease, explores risk factors and corrective tips associated with sleep apnea. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40042]

What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph. D., a leading expert in healthy aging, dementia, and Alzheimer's disease, for an in-depth exploration of the latest research on cognitive decline. This comprehensive program delves into the science behind brain health, covering key factors such as exercise, diet, sleep, social engagement, vascular health, hearing...

Claudia H. Kawas, M.D., addresses Alzheimer's disease and related conditions in older adults, noting the challenge of accurate diagnosis and the resemblance of other brain conditions to Alzheimer's. She introduces "resistance" and "resilience," explaining how some individuals remain cognitively intact despite brain changes. Kawas suggests declining dementia risk due to improved vascular health man...

Alzheimer’s disease is a major health crisis that is projected to become an even larger threat in the coming decades. According to the National Institute on Aging, the number of Americans 65 and older with Alzheimer’s could rise from 5.8 million in 2020 to 13.8 million by 2050. Given the severity of this health crisis and the toll it takes on patients, their families and society, we must be prepar...

Thomas C. Südhof, M.D., Stanford University, discusses facets of the fundamental cell biology of ApoE and APP analyzed in stem cell-derived human neurons. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38405]

Dr. Songi Han, professor in the Department of Chemistry, Biochemistry and Chemical Engineering at UC Santa Barbara, talks about her research into the function of proteins in the body and how changes like protein Tau tangles can lead to neurological diseases like Alzheimer's. Series: "GRIT Talks" [Health and Medicine] [Science] [Show ID: 37869]

Tarek Rajji, MD, shares research from current trials combining brain stimulation with interventions including cognitive remediation. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 37598]

Dr. Georges Naasan discusses communication difficulties associated with the language syndrome of Alzheimer's Disease. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 37334]

Dr. Georges Naasan describes the symptoms seen in the frontal/executive syndrome of Alzheimer's disease. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 37335]

Research suggests that listening to or singing songs can provide emotional and behavioral benefits for people with Alzheimer's disease. Dr. Theresa Allison provides an overview of music in the context of dementia and caregiving relationships. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 37150]

Stem cell research is changing the way Alzheimer's disease is diagnosed and treated. Larry Goldstein, PhD and Doug Galasko, MD join Alysson Muotri, PhD to share the latest findings and what the future may hold. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36805]

Lawrence S.B. Goldstein, PhD discusses his career in science and his work to understand the molecular basis of neuronal defects in Alzheimer's Disease. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36338]

Researcher Alysson Muotri is using stem cells to study everything from autism to the Zika virus. In this excerpt Muotri discusses stem cell and brain organoid research for possible applications to human diseases. Series: "Health Matters" [Health and Medicine] [Show ID: 36301]

Interactive immune systems are at the center of cancer and other diseases. Dr. Matthew Krummel explores some lesser-known functions of the immune system related to memory making, arteriosclerosis, and gut health. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 36205]

Dr. Aimee Kao discusses key behaviors known to protect brain health. Dr. Kao looks at population trends and wonders if they tell a complete story. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 36154]

Dr. Aimee Kao looks at recent news in Alzheimer's Disease therapeutics including drugs in development and the potential of stem cells and genome editing. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 35238]

David M. Holtzman, MD of the Washington University School of Medicine discusses the mechanisms underlying neurodegeneration and how microglia and specific microglial genes such as TREM2 influence neurodegeneration in the setting of Aβ and tau pathology. Learn how this line of study may lead to new therapeutics and diagnostic testing for Alzheimer's disease. Series: "Brain Channel" [Health and Medi...

Worldwide 50 million people live with dementia. By 2040 over 70% of them will be living in the developing world. Dr. Shamiel McFarlane explores the social and economic cost of dementia around the world. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 34779]