Biohacking Beauty: The Anti-Aging Skincare Podcast

If you have been thinking about buying a LED mask, the hardest part is knowing what actually matters. The price range is all over the place, every brand seems to have some version of “FDA cleared” on the page, and a lot of the buying advice sounds scientific enough to trust. But none of that automatically tells you whether the device is strong enough to do anything meaningful for your skin. That i...

We have been getting the same question in our DMs for months now. Peptides are everywhere. Everyone is talking about them. But what actually has evidence behind it, what is hype, and where do hormones fit into all of this? So we went and found someone who has been living this conversation for 35 years, not just talking about it. Dr. Jennifer Berman is a urologist, New York Times bestselling author...

Creatine has been boxed in as a gym-bro supplement for decades, but the latest research shows it's doing far more than building muscle. It buffers brain energy under sleep deprivation, supporting bone density and mood stability through perimenopause, and freeing up methyl groups for detoxification and DNA repair. We dive deeper into this in the Biohacking Beauty Podcast with Dr. Dan Pardi. We also...

When summer skin starts looking dull, congested, tired, or slower to recover, it is easy to blame the obvious things: heat, sweat, sunscreen, long days outside, or the wrong moisturizer. So the conversation usually stays on the surface. Use SPF. Cleanse better. Switch to lighter products. Add antioxidants. But before we treat summer skin like another product problem, there is a deeper question wor...

Every fibroblast inside your dermis right now is asking 200 to 2,000 mitochondria to power its work in real time, and those mitochondria are descendants of a free-living bacterium swallowed by a larger cell 2 billion years ago. As you age, those mitochondria run slower and your cells build fewer of them to replace the ones that fail. In this solo episode, Young Goose co-founder Amitay Eshel breaks...

Roughly 25% to 30% of the population carries slow variants in the MAOA or COMT genes, the two enzymes responsible for clearing adrenaline, dopamine, and serotonin from the brain. For these individuals, common polyphenols marketed for inflammation and longevity, including curcumin, act as weak MAOA inhibitors that further slow neurotransmitter breakdown. The result is a quiet buildup of stimulation...

Your skin has a biological age and for most people, it's not the same as their chronological one. Mayo Clinic published the SkinSpan framework this year specifically to quantify it, and the 12 Hallmarks of Aging now have a direct application to dermal tissue. This raises an uncomfortable question: if you're already optimizing everything below the neck with NAD IVs, peptides, and red light, why is...

The melanocytes giving pigment to your skin right now might be older than your car. They have been sitting in your dermis for decades, and unlike the cells on your skin's surface, they do not get replaced. They have to keep themselves clean which happens through autophagy. In Part 2 of our autophagy deep dive, we get specific about how skin handles autophagy differently from other parts of the bod...

What if your skin could literally rebuild itself from the inside out? In this episode, we break down one of the most powerful and misunderstood biological processes in the human body: autophagy. From its Nobel Prize-winning discovery to the molecular machinery that drives it, we walk you through exactly what autophagy is, how it works at the cellular level, and why it matters far more than most pe...

Most of what the supplement and skincare industry sells for aging targets one pathway at a time. But your biology does not age that way. It declines across 12 interconnected processes simultaneously, and by the time one of them shows up on your skin, the others have already been running for years. We at Young Goose believe that skin longevity is not a topical problem. It is a whole biology problem...

Most of what goes viral on SkinTok is missing one thing. The part where someone actually checks if it works. In this bonus episode, Amitay and Anastasia break down three of the most viral skincare trends circulating today, red light therapy wands, at-home dermarolling, and tretinoin, and run each one through a biohacker's lens. Not to dismiss them outright. But to ask the questions the original vi...

Mothers sacrifice so much of themselves to carry another human being in their body for nine months. Even after childbirth, there's a phase called the fourth trimester because babies are still heavily dependent on moms for their survival. Motherhood looks different for every woman. For Anastasia, who is a first-time mom, motherhood looked particularly different since her family is overseas and she'...

Most of the NAD+ skincare on shelves right now is built on a misunderstanding. And if you've been trusting niacinamide to do the heavy lifting, this episode is going to change how you read a label. This episode is Part 2 of our NAD+ deep dive. Here, we get into what actually works to raise NAD+ in the skin, the real precursors, the delivery technology that gets them where they need to go, and the...

A lot of us treat hair loss the way skincare treats wrinkles, as a cosmetic problem to cover up. But almost every case of thinning, recession, or shedding has something deeper driving it, and by the time it shows up in the mirror, a significant amount of density is already gone. We at Young Goose believe that beauty is whole body care, and hair is one of the most metabolically active tissues in th...

Most people know NAD+ as a supplement trend. But very few understand what's actually happening inside their skin cells when it runs out or what's stealing it in the first place. By the time you're 45, you've lost half of the molecule that powers virtually every function keeping your skin young. Sadly, it only gets worse from there. The enzyme your skin uses for DNA repair can wipe out up to 90% of...

Most people treat their skin like a surface problem. But almost every persistent skin issue, from rosacea to eczema to accelerated aging, has something deeper driving it. That deeper driver is almost always the gut, the liver, or a backed-up detox pathway. We at Young Goose, always believe that skincare is whole body care and we want our community to identify the deeper causes of skin issues that...

Most people think that the stinging feeling, redness or tightness are always good signs of skin detoxification. Tricky enough, it can look like ‘glass skin’ or skin renewal. However, almost always the temporary tight and bright skin is a skin barrier issue in disguise. Skin barrier damage is one of the most misread signals in skincare. It looks like purging but it is actually your skin telling you...

Did you know that the most powerful anti-aging protocol isn't about how long you sleep? It's about when. Getting eight hours of sleep for skincare feels like a tough feat to achieve especially when life gets in the way. By understanding how your skin begins its optimal repair time, it’s still possible to achieve the best skin results without the guilt of not sleeping enough. In our quest in findin...

Molecular hydrogen is often described as a selective antioxidant, but that framing is incomplete. In this episode, we explore hydrogen as a mitochondrial hormetic signal that can influence redox balance, inflammatory regulation, and adaptive stress pathways. The key distinction is that delivery route changes mechanism. Oral, inhaled, and topical hydrogen act differently in the body, with different...

Chronic stress isn’t just a mental or emotional burden. It creates a biological cascade that disrupts mitochondrial function, accelerates inflammation, and shows up visibly in the skin long before deeper symptoms appear. We dive deeper into this in the Biohacking Beauty Podcast with Dr. Scott Sherr. We also talk about the sympathetic spiral of doom, why skin reflects mitochondrial decline before o...

Fascia is one of the most overlooked conversations in skin aging. We spend so much time thinking about collagen, serums, injectables, and trending tools, but very few people are talking about the structural system underneath the skin that influences how we actually age. If you are dealing with under-eye puffiness, jaw tension, posture changes, facial asymmetry, or feeling like your face looks more...

Being told your labs are “normal” and your cycle is still regular does not mean your metabolism and hormones are stable. Early insulin resistance can quietly increase inflammation, drive midsection fat gain, and accelerate skin aging years before menopause is officially diagnosed. In this Biohacking Beauty episode with Dr. Jila Senemar, we break down why regular periods do not rule out perimenopau...

Advanced skincare routines are more popular than ever, yet dryness, laxity, and visible aging still persist. The issue isn’t effort or discipline. It’s that skin aging is being treated as a surface-level problem instead of a cellular and structural one. We dive deeper into this in the latest Biohacking Beauty Podcast with Jess Kane. We also chat about how cell membrane health shapes visible aging,...

It’s Valentine’s Day, and while we don’t usually shape our work around holidays, this one felt different because we’re not just co-founders of Young Goose, we’re life partners. For us, care has always shown up in daily choices and consistency, the same philosophy behind how we think about skin longevity. In this special episode, we flip the format and recommend ingredients to each other based on r...

Skin problems are often the body’s earliest warning sign that detoxification, inflammation control, and nutrient absorption are already compromised. When detox demand rises and recovery systems can’t keep up, skin changes and aging-related signs become more pronounced. In this episode of the Biohacking Beauty Podcast, we sit down with Marina Moiseyeva to explore why medications and aggressive topi...