Authentic Biochemistry

Dr Guerra uses the Dialectical Method via the Logical Square of Opposition combined with an analysis of the current biomedical evidence associated with the COVID 19 corona virus  to obtain validated conclusions. 23 March 2020.

In this third segment on the grounding of Natural Science and the world View it advances,  Dr Dan Guerra introduces the endojective perspective for space-time and the foundation of knowledge toward the representation of phenomena as pattern recognition from a possibilistic metaphysical landscape via freely chosen inductive reasoning in an ultimately uncertain universe. Published 20 March 2020...

In this second philosophical segment, Dr. Guerra introduces space-time as a physical manifestation of the synthetic a priori of Phenomenological Metaphysics as he draws inferences from pre-Socratic concepts of vortices and co-mingles these ideas with Clerk Maxwell's explanation of the electromagnetic theory and quantifiable resolution for the velocity of light. Published on the IDES of March 2020.

In this first segment  of a three part series, Dr Guerra  sets out to ground his scientific principles with an a priori epistemological reasoning that leads to the transcendental method for instantiating metaphysics to perform biochemical, genetic  and physiological research. Recorded 11 March 2020.  

Dr Guerra explains how  there is a cumulative balance between S1P and Ceramide will influence apoptosis and change the regulation of autophagy by the complex interplay between mTOR, beclin, and Bcl-2 where S1P-dependent autophagy is thought to be a homeostatic, pro-survival response involved in the clearance of intra-cellular debris. Describing these systems within the context of inflammation...

Today's podcast establishes the significance of sphingolipids in maintaining normal biochemical and physiological homeostasis by detailing membrane organization of pathways and linkage to cell fate and the potential for pathobiology in human disease. Published 03 March 2020 by Daniel J. Guerra, PhD

Dr. Dan Guerra discusses a new publication reviewing the process of resident pulmonary macrophages and innate lymphoid cells in disease with attention to pathogen activation and hyperinflammation as potentiated by co-morbidities leading to poor clinical outcome. 01 March 2020 

Dr Dan Guerra recombines Coronavirus with Ceramide linked Neurological Disease and the Pro-Inflammatory Response. 28 February 2020.

In this Authentic Biochemistry Podcast, Dr. Dan Guerra explains the roles of acid sphingomyelinases and associated ceramide production on the NLRP3 inflammasome activation as linked to coronavirus pathogen molecular patterns and the production of proinflammatory cytokines 19 February 2020. 

Dr. Guerra discusses a published NEJM paper from late January (2020) that details the initial epidemiology of the novel Coronavirus from China and gives an insight on how sphingolipid metabolism may be a potential pharmacotherapeutic target. Podcast Published 03 February 2020.

Dr Guerra of Authentic Biochemistry starts his  lecture series on the current disease-causing Coronavirus from China. This first segment gives detail on the basics of molecular arrangement, replication, intracellular trafficking through the ER-Golgi and ultimate virion transmission with some medical-historical references to the more common animal Nidovirales/Coronavirales and the previous hum...

Professor Guerra arrives at the functionality of autophagy and bioenergetic coupling via chemokine and cytokine signalling through antigen presenting cell population mediated germ center secondary lymphoid organ resident B cell somatic hypermutation via T follicular-helper  cell activation thus evincing the autoimmune paradigmatic disease system lupus erythematosus. 28 January 2020.

Authentic Biochemistry's Dr Dan Guerra gathers published  biomedical literature to offer mechanisms and means for sphingolipids  and amino acids to make a pathobiochemical donation to immunoepigenomic neurodegenerative disease. 21 January 2020.

19 January 2020. This is a podcast delivering Part 3 in my new arc describing the significance of biochemical and epigenetic reprogramming of T lymphocytes in human autoimmune disease. Parts 1&2 of this series are found as video lectures at https://www.youtube.com/playlist?list=UUcEoA2N9WSlNvDk1BtuznfQ . Dr Daniel J. Guerra of VerEvMed and Authentic Biochemistry. 

Dr Guerra investigates T and B cell mediated autoimmune induction in this critical podcast lecture before the full analysis of these destructive human diseases are authentically examined in the peer-reviewed biomedical literature.

As it turns out, autoimmune bacterial  epitope mimicry can play a crucial role in autoimmune primary biliary cholangitis and may correlate to major human disorders such as lupus . Prof. Guerra examines a series of papers from the primary literature to focus attenuation on T cell sub-population differentiating dynamics production.related to Plasma cell IgG 

T Lymphocyte communication with antigen presenting innate immune cells coupled with B cell activation may be regulated by a glycoprotein that links to discrete glycosylation patterns on membrane polypeptide domains

The epigenetic control over gene expression via transcriptional and post-transcriptional molecular interactions through time including interfering RNA and covalent modification of chromatin results in enivonmental, nutritional and age-related phenotypes . In this episode of Authentic Biochemistry, Dr. Guerra starts investigating  the molecular mechanisms employed.

Professor Guerra begins an arc of lectures on the molecular events that describe the covalent modification and temporal variation of gene expression collectively called epigenetics.

Prof Guerra gives a brief examination of Leptin -associated cancers. 15 October 2019

Dr Guerra discusses the intricate roles of Leptin and its receptor in various human diseases. 10 October. 2019

Dr Guerra of Authentic Biochemistry provides his  third discussion of adipokine-mediated control over obesity and associated disease from animal models to clinical disease. 02 October 2019.

Dr Dan Guerra pursues how Leptin and POMC regulate neuroendocrine and neuro-appetitive behaviours that link obesity and associated metabolic and life-style disease with the dysregulation of energy homeostasis

Dr. Guerra of Authentic Biochemistry and the VerEvMed YouTube channel provides critical in-depth neuro-anatomical and HPA axial complicity in Leptin Signaling from the Adipose to the stress- and basal regulation of human physiological responsiveness. 22 September 2019 

In this Authentic Biochemistry Podcast Episode Prof. Guerra describes the specific metabolism of very long chain polyunsaturated fatty acids from essential dietary precursors of both the Omega 6 and Omega 3 series and associates these pathways with a recent 2019 publication that provides evidence for Omega 3 fatty acid inhibition of adipose stem cell associated IL17a  proinflammatory  cy...