Authentic Biochemistry

Dr Guerra explains how  mutations in the glycolytic enzyme, pyruvate kinase,  may lead to histone phosphorylation and the florid production of pro-oncogenic events. 24 July 2020.

Dr. Guerra delivers lecture 2 on human aging with a walk on the other side of cell fate:-pathobiochemical immortalization during oncogenesis. Published 21 July 2020

Today I start this robust examination of human aging from the fundamentals of life span and the molecular events that mediate the rate of senescence. This is Part One. Also please consider contributing to Authentic Biochemistry by becoming a patron on Patreon. I need your support!  https://podbay.fm/podcast/1454408625

The synthesis of protease-mediated hyper inflammation in pre-morbid respiratory distress pathobiochemical states linked to coronavirus transmission . How COPD and ARDS in association with cardiovascular disease, diabetes and lung dysfunction pre-dispose to viral infection and illness. Published 11 July 2020.

Airway passage disease has been well characterized in  cystic fibrosis and this research which involves both clinical and animal model systems can inform general respiratory distress syndrome and viral pneumonia as that ascribed to the coronavirus 19. Published 10 July 2020

Dr Guerra presents his existential view on the purposive avoidance  in science to admit the significance of belief in the knowledge paradigm. 09 July 2020.

Dr Guerra recaps protease mechanisms and zymogen activation ultimately linking serpin mediation of neutrophil elastase during coronavirus infection. Published 08 July 2020

Dr Guerra presents how a protease inhibitor protects a serine protease that is linked to ovarian cancer progression plus how protease inhibitor polymerization overloads the Endoplasmic Reticulum Associated Degradation pathway and Unfolded Protein Response to induce autophagy-linked Hepatocellular Carcinoma. Finally,  a mechanistic step-wise summary of the serine protease catalytic triad &nbsp...

Far from becoming monomeric and unimodal in effect, the anti-trypsin protease inhibitor functions to modulate the transcriptome and proteome of induced pro-inflammatory responses in both systemic and  tumor microenvironments.  Dr Dan Guerra 30 June 2020

Dr Guerra targets his lecture on protease inhibitors as positive acute phase proteins serving a modality of repression against proteolytic degradation processes as induced by the pro-inflammatory cytokine mediated hyper-immune response. Published 29 June 2020.

In this  session Dr Guerra discusses the physiological and pathophysiological roles of serine protease inhibitors (SERPINS). For example,  the physiological role of plasminogen activator inhibitor 1 (PAI-1) involves control over fibrinolysis  which is an essential  hemostatic mechanism for regulating the dissolution of fibrin clots associated with airway passage remodeling &nbs...

In this Lecture I define and then implement  a dialectical approach to biomedical scientific research methods that involves event ontologies relative to a non-paradoxical understanding of cancer pathobiochemistry. Published 19 June 2020 by Dr Daniel Guerra

Dr. Dan Guerra apprehends several research publications going back to 2012  and proceeding through 2019 in a synthesis of oppostional logic and the published scientific evidence to explain the mediation of metabolic zonation, transcriptional control, and bioenergetcs using PEDF to mitigate cancer progression.  

A brief concluding lecture on   the linkage of obesity with Type 2 diabetes plus a clinical case study discussion and review question of a mis-diagnosis via anchoring. 

Dr Guerra lays out the prodromal manifestations of metabolic syndrome and insulin resitance that can lead to Type 2 diabetes in the obese sedentary aging population.

Dr Guerra lays down the basics of bioenergetics and the roles of carbohydrate and lipid metabolism in the obese state leading to type 2 diabetes and the pathophysiological sequalae in chronic disease. 25 May 2020b.

Dr Guerra reminds his audience that obesity is the global health pandemic of a generation and that it leads to multiple high mortality diseases associated with a corruption in lipid metabolism, both innate and acquired immunity and associated cancer and cardiovascular disorders. Because obesity sets as a precondition and continued distress to human health and well-being, the predisposition to a co...

Dr Guerra provides the basic detail necessary to prepare one for our future examination of the current peer-reviewed literature involving hormonal control over health , infection and inflammation via the immune system.

Dr Guerra discusses hormonal ontology via receptor -binding mechanisms plus the cascade of the hypothalamic-pituitary axis.  

Dr Guerra gives a fast paced knowledge-laden series of lectures on the medical physiological and biochemical features of human hormonal signaling. Lecture I Introduction and Classification. Published on line 04 May 2020

Dr Guerra  opens up the refereed published scientific literature to provide verified evidence associated with the arcuate nucleus of the hypothalamic arc leading to hormonal  control over nutrition and the immune system. Published 28 April 2020

Patho-Biochemical Pathways in CNS-Endocrine Organs with a special emphasis on sphingomyelin phosphodiesterases in the HPA axis of the CNS and Beta hemolysins as virulence factors from the human bacterial pathogen, Staphylococcus  aureus. Dr Daniel J Guerra published on 27 April 2020.

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Dr Guerra delivers his third informed discussion of Membrane lipid raft biology and the role of Sphingolipids in mediating an immune response that results in massive tissue damage and poor disease outcome. Published 11 April 2020

In this audio lecture presentation, Dr Guerra gives an aggregated explanation for the association of subcellular biochemical metabolism of sphingolipids via the target of Cationic Amphipathic Drugs such as SSRI's in altering cell fate from programmed cell death to tissue preserving autophagy. Published 11 April 2020.