Dr Daniel J. Guerra

Authentic Biochemistry

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Dr Daniel J. Guerra

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Immune Cell Biochemistry I. T Lymphocyte Membrane.C.15. Authentic Biochemistry Podcast.Dr Daniel J. Guerra.01May2024. 02.05.2024 29:46

References Trends in Immunology. 2017. REVIEW| VOLUME 38, ISSUE 4, P287-297. FASEB J. 2020 May;34(5):6185-6197. Couperin, F. 1714. Troisième Leçon De Ténèbres À 2 Voix https://youtu.be/UbREakKFTow?si=JqmA1GQQpTOItUSg Lennon-McCartney. 1970. "Let it Be" https://youtu.be/QDYfEBY9NM4?si=nH4LJs4gprJVvcR1

Immune Cell Biochemistry I. T Lymphocyte Membrane.C.14 Authentic Biochemistry Podcast. Dr Daniel J. Guerra. 30.4.24 . 01.05.2024 29:56

References Nutrition. 2021-11-01, Volume 91, Article 111388 Front Immunol. 2022 Jan 5:12:806529. Cells. 2019 Aug; 8(8): 939. Lennon-McCartney 1963."She Loves You" [Beatles Second Album; lp] https://youtu.be/oVCwDl-S09A?si=ZjD89e5pwvXf5864 Schmelzer, JH, 1664 " Violin Sonata, in A Minor. 'Cucù'" https://youtu.be/x1TsJFeB2x8?si=JiqwHG2GcOf2ddeT

Immune Cell Biochemistry I. T Lymphocyte Membrane c.13. Authentic Biochemistry Podcast. Dr .Daniel J. Guerra.28.4.24 . 29.04.2024 29:02

References Int J Mol Sci. 2019 Oct; 20(20): 5028 Nutrition. 2021-11-01, Volume 91, Article 111388 Bach, JS. 1720. "Brandenburg Concerto No. 6" in B Flat Major. BMV. 1051. https://youtu.be/_tr_uYEQkrs?si=rXXWMBAnWGbEuAOk Hunter-Garcia. 1970. "Stella Blue". [Wake of the Flood;lp] https://youtu.be/VKsWDyvWaL4?si=DnHgzSEiiKeUOXbj

Immune Cell Biochemistry I. T Lymphocyte Membrane Biochemistry c.12. Omega -3 fatty acids and mdiminished macrophage inflammatory gene expression. Dr. Daniel J. Guerra Authentic Biochemistry 26..4.24 27.04.2024 28:33

References Int J Mol Sci. 2019 Oct; 20(20): 5028. Lennon-McCartney. 1964. "Ill Be Back" https://youtu.be/fJSTBNTac6k?si=rr4rWE86TIs8EZcL Bruch, M. 1866. Violin Concerto 1. G minor https://youtu.be/9BeV9XDs64w?si=AvEAQch7T8TJrt05

A brief introduction to an epistemological dialectic directed toward research science. Dr. Daniel J. Guerra. 25.4.2924. Authentic Biochemistry Podcast 26.04.2024 30:00

Kant, I. 1791 "Critique of Pure Reason" Augustinus, A. 397. "Confessiones" Book 11. Plotinus 253. "Ennead III" Beethoven,L. 1799. Septet Es-Dur op. 20 https://youtu.be/pXsj43qCcUA?si=lWoBhVSC4WhT8uUP Winwood-Capaldo. 1970. "Empty Pages " [Traffic: John Barleycorn Must Die,lp] https://youtu.be/5ycyIkcX7zU?si=jUJ6U2u31_SL1vNR

Immune Cell Biochemistry I. T Lymphocyte Membrane Biochemistry c.11. Dr. Daniel J. Guerra. Authentic Biochemistry. 24.4.24 25.04.2024 30:00

References Circulation. 2023.Oct 17;148(16):1231-1249. Int J Mol Sci . 2019. Oct 11;20(20):5028. Front Immunol. 2019; 10: 1706 Mastin, T. 1967 "How do you Feel" [Jefferson Airplane]. Surrealistic Pillow.lp. https://youtu.be/iWUa-rKT-oY?si=1M9496MbDUBGuj0A Hunter, Garcia, Kreutzman. 1975. "Franklin's Tower" [ Grateful Dead. Blues for Alah].lp. https://youtu.be/55TOIJxKc74?si...

Immune Cell Biochemistry I. T Lymphocyte Membrane Biochemistry c.10. Immune cell membrane glycosphingolipids. Dr. Daniel J. Guerra Authentic Biochemistry 23.4.24. 24.04.2024 29:52

References Guerra, D. 2023-24 lipid lectures J Oleo Sci. 2011; 60(10): 537–544. Gregorian Chants: 1100 AD. Beata es Virgo Maria https://youtu.be/rMlWhAh2Zvc?si=B3XqzCsQYef_ee6t Schubert, F. 1822. Schubert | Mass No. 5 in A flat major D 678 https://youtu.be/Yl5YF3PeUeI?si=AP9U_WHULnv3ItWi

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry. c.9. The involved CH2O sequence event ontology. DJGPhD.22.4.24 23.04.2024 29:31

References J Am Soc Mass Spectrom. 2023 Nov 1;34(11):2481-2490 J Oleo Sci. 2011; 60(10): 537–544. Trends Immunol. 2018 Jul; 39(7): 523–535. Blood. 2014 Dec 4; 124(24): 3656–3665. George, L. and B. Payne. 1970. "Truck Stop Girl". Byrds. [Untitled] lp. https://youtu.be/fdI83TNKdX4?si=JWPrSMCHEX5G1zi9 Georgia Dobbins, William Garrett, Freddie Gorman, Brian Holland, Robert Bateman. 1961. &qu...

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.8. 20April 2024.Authentic Biochemistry Podcast. Dr. Daniel J. Guerra. 21.04.2024 30:00

References Dev Cell. 2016 Jul 25; 38(2): 161–169. J Biol Chem. 2010 Jul 16; 285(29): 22328–22337 Landes Bioscience ; 2000-2013.Madame Curie Bioscience Database [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK6207/ Nat Med. 2003 Aug;9(8):1020-5 National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 107970, Fingolimod. Retrieved April 20, 2024 from https://pubchem.n...

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry. c.7. .18April 2024.Authentic Biochemistry Podcast. Dr. Daniel J. Guerra 19.04.2024 29:47

References Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28): 8661–8666 J Exp Med. 2021 Nov 1; 218(11): e20210417 J Biol Chem. 2010 Jul 16; 285(29): 22328–22337. Brahms. J. 1879. Violin Concerto D. Major. OP 77. https://youtu.be/9L6a-JJCCzw?si=r7IAjxBC8ZBfDOaR McCartney/Lennon.1967. "She's Leaving Home" on [Beatles] SPLHCB lp. https://youtu.be/VaBPY78D88g?si=n2R4CQF6tm8TuM9h

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.6. 17April 2024.Authentic Biochemistry Podcast.Dr. Daniel J. Guerra. 17.04.2024 30:00

References Cold Spring Harb Perspect Med. 2020 Jun; 10(6): a034819 Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28): 8661–8666 Blood. 2010 Jul 22; 116(3): 485–494. Haydn, FJ. 1793. Symphony No 101 D major "Die Uhr“. https://youtu.be/jK9EPZ3qdgU?si=GiCVxNOchDW0fKsb Croce, J. 1970. "Time in a Bottle". https://youtu.be/9h1davKgBYM?si=YhyPwAtno04oYBks

T lymphocyte Membrane Biochemistry I. Immune Cell Biochemistry I c.5 Authentic Biochemistry 16April2024 Dr Daniel J. Guerra 17.04.2024 29:51

References Front. Immunol., 2022 Sec. Microbial Immunology Volume 12 Blood 2010. Volume 115, Issue 18 , 6 May: 3708-3717 Seeger, P. 1959 . Performed by The Byrds "Turn Turn Turn" https://youtu.be/W4ga_M5Zdn4?si=ODKk_snS-5XHZvWP Copland, A. 1944. "Appalachian Spring. https://youtu.be/CJYVH_kZkOk?si=UUBet58ETg0PVUrB

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.4. 15April 2024. Chemokine gradients and the membrane lipid raft. Authentic Biochemistry Podcast Dr. Daniel J. Guerra 16.04.2024 29:58

References FEBS J. 2018 Aug; 285(16): 2944–2971. Nature Reviews Immunology 2023. volume 23 , pages 236–250. Angiogenesis. 2021; 24(4): 719–753. Front. Immunol. 2022 Sec. Microbial Immunology Volume 12 Camp, H. 1964. "Pride of Man". performed by Quicksilver Messenger Service. https://youtu.be/fG6A6G9uzsQ?si=tKMdQMVbpTn2x85D

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.3. 14 April 2024 .Authentic Biochemistry Podcast.Dr. Daniel J. Guerra 15.04.2024 29:57

References Nat Rev Gastroenterol Hepatol. 2022 Jun;19(6):351-366 Drugs. 2016 Jul;76(11):1067-79. Front Immunol. 2021; 12: 613591 J Appl Microbiol. 2009. Jun;106(6):1908-18 Exp Cell Res. 2015 May 1; 333(2): 195–200. Mediators Inflamm. 2017; 2017: 4806541. Parsons, G. McQuinn,R. 1971. Pale Blue [ Byrds] Byrdmaniax lp. https://youtu.be/Mh3J7GqrdzY?si=Kp0XfrwPtSi4vY6q Baker, G. 1967. "Blue Condit...

Immune Cell Biochemistry I.T lymphocyte Membrane Biochemistry c.2 Lipid mespmorph and radius assymetry direct Tcell membrane sterol and protein interdigitation that is altered by pressure via PV=nRT. 13.04.2024 30:00

References and simple equations PV = nRT where P is pressure (in atm), V is volume (in liters), n is number of moles and T is temperature (in K); R is a constant and is equal to 0.08206 L atm/moleK. Molecular Shape including thickness(radius) of membrane curvature is v/al where v=volume,a=area per headgroup, and l=thickness of the hydrocarbon monolayer Guerra, D. Membrane Biochemistry notes

Immune Cell Biochemistry I.T lymphocyte Membrane Biochemistry c.1. DJGPhD.11April24.Authentic Biochemistry Podcast 12.04.2024 29:55

References Front Immunol . 2021 Mar 10:12:613591. Guerra, D. 2020's. Membrane Biochemistry Lectures Crosby, D., Kantner, P., and Stills, S. 1968. "Wooden Ships" [Jefferson Airplane ] from Volunteers lp. https://youtu.be/ROBaoiJK0wc?si=ABsxa4m4AjjAwoms Mendelsshon, F. 1830. "The Hebrides Overture"-Fingal's Cave. OP26. https://youtu.be/MdQyN7MYSN8?si=w9G1d0_5DFJn-tzx

Biochemical Mosaic III. Coda. DJGPhD .09April24.Authentic Biochemistry Podcast 10.04.2024 30:00

References Guerra, D. 2024. The Mosaics I-III. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Beethoven, LV. 1806. Violin Concerto D Major. Op 61. https://youtu.be/cokCgWPRZPg?si=pKKUsINChgI14PH9

Biochemical Mosaic III. c.14. From physical chemistry to the mechanisms of sphingomyelinase mediated inflammation: abrief dialectical accounting of research involving abiotic vs biological phenomena. 08.04.2024 30:00

References Guerra, D. 2024. Previous Lectures: Authentic Biochemistry. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Waters, R.1973. "Eclipse" from [Dark Side of the Moon]; Pink Floyd lp. https://youtu.be/k0xGxnZFNYs?si=VrfYPQuXef41Drfm Holst, G. 1918. "The Planets" https://youtu.be/HP5xhyPn58U?si=IdN_iqJNvt_tjQKP

Biochemical Mosaic III.c.13. A priori intralocution of inflammasome genomic loci with stress phenomena immunoepigenetically resolves defensive inflammation. DJGPhD.6April24. Authentic Biochemistry. 07.04.2024 30:00

References Guerra, D. 2024 Previous Mosaic III lectures and content. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Hayward, J. 1969. "Never Comes the Day" from Moody Blues lp. Threshold of a Dream. https://youtu.be/8u1zH11yqFQ?si=xtXp1SWm8rF1RdFS Mozart, WA.1785. String Quartet No. 19 in C Major , K. 465 https://youtu.be/f3oK4XVMARs?si=FMypvP8O_WCII7vR Page, J...

Biochemical Mosaic III. c12. A prolegomena to any future biochemical Instanence. Dr Daniel J. Guerra. 4April2024. Authentic Biochemistry Podcast 05.04.2024 29:57

Refernces Guerra, DJ. Inclusive non-extemporaneous reasoning on biochemical event ontologies. Jefferson, Blind Lemon 1927, Hunter-Garcia 1969 Jefferson's "I know You Rider" and "China Cat Sunflower" . Grateful Dead. Europe 72' LP. https://youtu.be/xCgZxrf8nrU?si=k7WGmY-fo_AjEip- Schmelzer, JH 1664. Violin Sonatas, "Romanesca". https://youtu.be/fB8G39y1uCA?si=h...

Biochemical Mosaic III. Inflamasomes c.11 A Dialectical Event Ontological conciliantus contrarion perspective.DJGPhD.3April24.Authentic Biochemistry Podcast. 04.04.2024 29:22

REferences Guerra, DJ. 2024. Biochemical Mosaic III lectures. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Dvorak, A. 1879. Romance in F minor, Op. 11, (B. 39). https://youtu.be/XZTeavJ9frA?si=18LFzAQ9FKfrQ_16 Dylan, R. 1975. "Tangled up in Blue" performed by Gerry Garcia Band (live;1977) https://youtu.be/8Aw7FW1Frjs?si=jURQC3jBWFPirSh8 Betts, R. 1972. "...

Biochemical Mosaic III.c.10 Atherogenesis and neointma formation are associated with sphingomyelinase membrane raft NOX aggregation during inflammasome activation.DJGPhD.2April24 03.04.2024 29:47

References J Lipid Res. 2022 Dec; 63(12): 100298. Mol Cells. 2020 Aug 31; 43(8): 749–762. Bach J.S. 1727. St Matthew Passion, BWV 244. https://www.youtube.com/live/3fP-rET0kFI?si=ZX-edMPg1wBA_5mh Squire, Chris. 1978. "You Can Be Saved" Yes. https://youtu.be/0TNzPHoVlz8?si=bFMp6w4T2SL6XxS4

Biochemical Mosaic III.c.9 Clinical associations of inflammasome mediated pathophysiology linked to epigenetic methylation patterning and DNA repair. DJGPhD.1April24. 02.04.2024 30:00

References Redox Biol. 2020 Apr; 31: 101482 Nat Rev Microbiol. 2009 Feb; 7(2): 99–109. J Neuroinflammation. 2019; 16: 236. Front Pharmacol. 2021; 12: 643254. Biber, H. 1676. "Passagalia" por solo violin https://youtu.be/sgcR183f8gA?si=ovfSbdg6WsfuIiTw McBroom, A. 1976. "The Rose" Conway Twitty https://youtu.be/cO59ITNCxzk?si=ueMmXtzMNH4YeQ_w Hunter-Weir. 1970. "Sugar Magno...

Biochemical Mosaic III.c.8. S. aureus clearance via dual pyroptosis and necroptosis salientsand the control over the hyperinflammatory axis of clinical disease. DJGPhD.31.3.24 01.04.2024 29:19

References Cell Reports 2016.Volume 16, Issue 8, 23 Pages 2219-2230 Front Immunol. 2020; 11: 621733 Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969

Biochemical Mosaic III.c.7 Convergence of Inflammasome molecular patterning obtains PRR-like sequalae that are hypo-modified epigenetically in multple Human pathophysiologies 28.03.2024 30:00

References Int J Mol Sci. 2021 Jul; 22(14): 7580. Trends Biochem Sci. 2023 Apr;48(4):331-344 Immunology. 2020;159:142–155 Curr. Opin. Immunol. 2020;62:39–44. Nat. Rev. Mol. Cell Biol. 2019;20:569–570. Lennon-McCartney. 1963. "This Boy" https://youtu.be/lW5D7HpYhBU?si=mHyiFng3rd3pukob Lennon-McCartney.1966. "And your Bird Can Sing" https://youtu.be/sOUlbredoUM?si=nPB64c8GS4joYx9...