Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1250 episodes

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Dr Daniel J. Guerra

Episodes

Sarcopenia IX. The Interplay of quinone reductase and PGC1-alpha in mitochondrial event dynamics. Dr. Daniel J. Guerra. 28.9.24 29.09.2024 34:23

References Nature Communications 2024. volume 15,1541. Campbell, Ian. 1963. The Sun is Burning. https://youtu.be/3L2Tn-YFlKk?si=pFTaj6iG9q4x-LR7

Sarcopenia VIII. Parkin expression in adipose linked to bioenergetics and mitochondrial fate associated muscle metabolism. DJGPhD.25.9.24 26.09.2024 1:13:48

References Nat Commun. 2022; 13: Article Number:6661. Nature Commun. 2024; 15: Article number:1541 Myrow and Gordon 1946. You Make Me Feel so Young. Sinatra https://open.spotify.com/track/6N1amIkGGddramWRDrP3Nm?si=0de15d2fec054455 Mozart WA. 1773 Symphony 24 in G minor. K.183 https://youtu.be/707oHEGF6l8?si=E_1zWSSN5zRAHs9i

Sarcopenia VII Authentic Biochemistry Podcast. Dr Daniel J. Guerra 23.9.24 24.09.2024 58:35

References Endocr Rev. 2020 Aug; 41(4): 594–609. Sci Signal. 2017 Jan 31; 10(464):eaaf7478. Nat Commun. 2022; 13: 6661 Acta Physiologia (OXFORD) 2024. Volume240, Issue3March.e14111 Cell Metab. 2022 Dec 6; 34(12): 2036–2046.e8.

A Dialectical Eventual Disclosure of Metabolic Temporality. Dr Daniel J. Guerra. 21Sept24. Authentic Biochemistry Podcast 22.09.2024 43:25

References Plato 360 BC. "Timaeus" Plotinus 250 AD. "Ennead III" St Augustine 426 AD. Des Religiones. Guerra, DJ. 2024 manuscript in preparation Von Bingen, H. 1174. Various compositions in "Plainchant" https://open.spotify.com/album/6E5bJgcbFNZDqTnYAOxDFw?si=gQcsyjwjQquOPAbA_Oud1A

Authentic Biochemistry Podcast. Sarcopenia VI. Dr Daniel J. Guerra 19. 9.24 19.09.2024 1:02:46

References Front. Physiol. 2021. 02. June. Vol.12 Nature Aging 2021. volume 1, pages 60–72 Teleman, JF. 1723 . "Wassermusick" Concerti TWV 55:C3 https://open.spotify.com/album/7cbAYEr4FJf8fAG6upSFgL?si=E_gnKD4QRUuu7xqhSpt9fQ Hayward, J. 1967. "Nights in White Satin" Moody Blues. https://open.spotify.com/track/6L5BZEcZmD6RBJnimzlyKr?si=4d8a0d1e77494b98

Authentic Biochemistry Podcast Sarcopenia V. Dr. Daniel J. Guerra 16.9.24 17.09.2024 49:03

References HORMONES 2013, 12(2):172-191 Eur J Endocrinol. 2017 176(5): R235–R246 Amino Acids. 2012 Oct;43(4):1803-7 Cell Metabolism 2020 31472-492DOI Kirwain, D. 1972 "Dust" Fleetwood Mac [Bare Trees lp.] https://open.spotify.com/track/2yE8gE3zBfflRklTKIlpiv?si=d1cbe70445c34fa6

Sarcopenia IV. The CH20 Signaling Metabolome Circuit Involving the CNS, Liver, Adipose and Skeletal Muscle. Authentic Biochemistry Podcast Dr. Daniel J. Guerra 14.9.24 15.09.2024 1:02:42

Guerra, DJ. 2024. lecture notes Leach, Donovan. 1967 "Mountain Jam" Allman Brothers https://youtu.be/w9ZubobGMLs?si=uHLon1CvCiCSiqtX

Authentic Biochemistry Podcast Sarcopenia.C.3 AMPK Control over Pyrimidine and Purine biosynthesis via mTORC. Dr. Daniel J. Guerra. 11Sept24 12.09.2024 51:58

References Experimental & Molecular Medicine.2016. volume 48, 224 Nature Metabolism 2023. volume 5, pages 277–293 Nature Reviews Drug Discovery 2019. v18. : 527–551 Pisendal . JG. 1730's. Violin Concerti. https://open.spotify.com/album/6dC3dq8i6rDeeKtz5LyhFZ?si=jUsRMIraR7-zO5o0UQGMdw

Sarcopenia C.2 Authentic Biochemistry Podcast. Dr Daniel J. Guerra. 10Sept24 11.09.2024 57:47

References Acta Physiologica (Oxford)2024. V.240.Issue 3 e14107 Hum. Mol. Genet. (2016) doi: 10.1093/hmg/ddw252 Amino Acids. 2016 Aug;48(8):1793-805. European Journal of Applied Physiology 2013, Volume 113, Issue 4, pp 987–996 Lennon-McCartney. 1969. "Carry that Weight" from Abbey Road lp. https://open.spotify.com/track/5eZrW59C3UgBhkqNlowEID?si=cddd237e073047c8 Anderson and Howe. 1973....

Sarcopenia Molecular Pathology. Dr. Daniel J. Guerra. 09Sept24. Authentic Biochemistry Podcast 10.09.2024 59:02

References Acta Physiologica (Oxford)2024. V.240, Issue 3 e14107 Int. J. Mol. Sci. 2023, 24, 5564 Simon, Paul and Bruce Woodley. 1966.The Cyrkle. "Red Rubber Ball" https://open.spotify.com/track/6DuLN8tFW0DkH9wsbTHZsX?si=3bc8b99f3ae34ac6 Robert Fripp, Ian McDonald, Greg Lake, Michael Giles, Pete Sinfield English 1969. "Court of the Crimson King" King Crimson https://open.spotif...

Concerning Technical Difficulties on the Recent Video Lectures.DJGPhD.08Sept24. 08.09.2024 15:57

References Previous discussions

Authentic Biochemistry Podcast. Alzheimer’s Disease coda. Dr Daniel J Guerra.04sept24 05.09.2024 1:20:08

Correction: In my lecture I incorrectly used the W single letter designation as representing tyrosine. I miss-spoke . W=tryptophan while Y=tyrosine. The WW domain discussion is important for specific protein:protein interactions wherein the tryptophan (W) residues (found in the beta1 and beta 3 folds) are separated by 20 -22 amino acids that contain certain tyrosine (Y) residues in the beta2 regio...

Authentic Biochemistry Podcast Moment. Dr Daniel J Guerra. 03Sept24 04.09.2024 5:47

References Guerra, DJ. 2024 Moment in time. Willy and Joe Chambers. 1966. "Time Has Come Today" https://youtu.be/hIqwzQ7g-Cc?si=H17GGSKbeEyNXuE6

Authentic Biochemistry Podcast. Pharmacotherapeutic drug mechanisms and their molecular targets in AD. DJGPhD.02September24. 03.09.2024 52:58

References ASN Neuro. 2024 16:1, 2371160 Alzheimer's Research & Therapy.2024. volume 16, Article number: 144. Neurosci Res. 2008 Mar;86(4):744-54. Mozart, WA. 1775. Violin Concerti 3-5 https://open.spotify.com/album/0QFZNXt8rfAeqZbDGiixxc?si=n3BJ4g3VSaWIlwl3iSmZPA

Authentic Biochemistry Podcast. The Insulin Involvement in Kinase Cascade Expansion of Tau and A- β Pathology 01September 2024 Dr. Daniel J. Guerra 02.09.2024 53:22

References Mini-Reviews in Medicinal Chemistry. 2022, Vol. 22, .#22. Brain Research 2024.April 15. Vol.1829.article 148793 Miller. S. 1968."Quicksilver Girl" https://open.spotify.com/track/1gXEKJBTx2sLhY3AWkG6tu?si=43c6fcd157e64f9d Bach, JS. 1735. The Italian Concerto & Partitas https://open.spotify.com/album/6Sbk3UQiGoIagydUA4URdi?si=rweGy9M1QBK3Y4ETha9rDw

Authentic Biochemistry Podcast Sphingolipids and Kinase Modulatory Influences on AD Proteinopathies 30 August 2024 Dr. Daniel J. Guerra 31.08.2024 1:01:13

•ReferencesMini-Reviews in Medicinal Chemistry. 2022, Vol. 22, .#22.Brain Research 2024.April 15. Vol. 1829.article 148793Ann Clin Transl Neurol. 2020 Feb; 7(2): 160–168.Biber. 1676. Mystery Sonatas. Romenesca.https://open.spotify.com/album/525eA1aCikerrBhLbe29Ms?si=r1BohC3uTv2V_NbmeXAJng

Authentic Biochemistry Podcast Alzheimer's Disease Pathobiochemical Inception Involves Mitochondrial Dysfunction. Dr. Daniel J. Guerra.27.8.24. 27.08.2024 48:08

References Brain Research 2024.April 15. Vol. 1829.article 148793 John Kay , Jerry Edmonton , Nick St. Nicholas , Larry Byrom , 1969. Steppenwolf. Monster title cut. https://open.spotify.com/track/0UwWLG6L2vm1r1fd1QDHqy?si=6a73e4a6eacd4328

Authentic Biochemistry Podcast. Primer; Nucleotide Biochemistry I DJGPhD.25.8.24 26.08.2024 28:45

References Guerra, DJ. 2024 Nucleotide Graduate lectures Hunter-Garcia 1970. "Attics of my Life" Grateful Dead [American Beauty, lp.] https://open.spotify.com/track/6WeLHc9eLjVJqOKhd97vaK?si=d93bcc38ba7d4bac

Authentic Biochemistry PodcastIntermediary metabolism, epigenetics, and the endomembranous network surveil, ascertain, and deliver upon cellular event ontology Including AD pathology.DJGPhD.24.8.24 25.08.2024 59:31

References Free Radic Biol Med. 2021 Jul; 170: 59–69. Biomolecules.2021 Feb; 11(2): 195.

Sphingolipids in AD: The Fragmentation of Mitochondrial DNA and Innate-Immune activation of inflammasomal CNS pathologies Dr Daniel J. Guerra 23.8.24 Authentic Biochemistry Podcast 23.08.2024 38:05

Refs Front mmunol.2019; 10: 1064 Fosdick and Poulton 1956. Love me Tender https://youtu.be/v5SkY9WHekg?si=q5Xhq32IHBNYdj81

AD is a Neurodegenerative Disease associated with Cytoepigenetic Interactions between the Nuclear and Mitochondrial Genomes. Authentic Biochemistry Podcast.c.8.Dr. Daniel J. Guerra.19.8.24 19.08.2024 56:42

References Front. Immunol., 2024Sec. Multiple Sclerosis and NeuroimmunologyVolume 15 22 February Mozart. WA 1778. Sinfonia Concertante. https://youtu.be/_0hTDZ0whpU?si=s4JhUsyFr1WZk4AQ

Immune and neuropathophysiology of CYTOEPIGENETICS Dr. Daniel J. Guerra 18AUGUST 202 19.08.2024 38:39

References Guerra, Daniel J. 2022. December Journal of Disease and Global Health .DOI: 10.56557/jodagh/2022/v15i38023 Lamm, R. 1969. "Beginning's" CTA. https://youtu.be/lI-BMDnti4c?si=ZCt7yL3xRRrH2l_b

Authentic Biochemistry Podcast Sphingolipid, ROS Mitochondrial Involvement associated with Nuclear Histone Acetylation in Alzheimer’s Disease 14.8.24 Daniel J. Guerra, PhD 15.08.2024 51:19

References Guerra, DJ 2024 Lecture materials

Inter Alia, The PDH/LDH/PDHK Axis for T Lymphocyte Activation intersection with AD pathobiochemistry. DJGPhD. 12AUG24 13.08.2024 1:04:42

References Neuromolecular Medicine. 2018. Jun. 20(2): 1559-1174 Cell Rep. 2018 Feb 6; 22(6): 1509–1521 Cell Cycle .2008.7(15):2296-8 Front. Immunol., 18 June 2013 Sec. T Cell Biology Tchaikovsky, PI. 1874. Piano Concerto 1. B Minor. Opus 23. https://youtu.be/W6Zr_0LYYTI?si=YlrIK-UDVGHbMp4P

AD and Sphingolipids c.5 Sphingomyelinase and Ceramide molecular heterogeneity in AD is associated with bioenergetics and Ketone availability. Authentic Biochemistry. 11Aug24 Dr. Daniel J. Guerra 12.08.2024 57:31

References EBio Medicine. 2015 Dec; 2(12): 1888–1904. J Atheroscler. Thromb.2023. Dec 1; 30(12): 1751–1758. Russian Orthodox Voices: https://youtu.be/z_M6YbsmT-I?si=l-U5ZwH90oCBbwAR