AudioAbstracts

Host: Ryan Quigley New findings from a post hoc analysis of the Burden of Disease survey highlight how symptom severity and loss of independence in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) contribute to increased caregiver burden, fatigue, anxiety, and depression. In this AudioAbstract, Ryan Quigley discusses which patient-reported symptoms and limitations were most strongly as...

Guest: Ryan Quigley New real-world data are reshaping the conversation around transthyretin suppression in transthyretin amyloidosis. In this AudioAbstract , Ryan Quigley explains how a crossover analysis revealed substantially deeper serum transthyretin suppression with vutrisiran than patisiran, raising important questions about whether more complete silencing could influence long-term outcomes.

Host: Hallie Blevins, PhD While transthyretin amyloid cardiomyopathy (ATTR-CM) is often viewed solely as a disorder of protein misfolding, a new review published in the European Heart Journal presents it as a dynamic imbalance between amyloid production and clearance. Hear from Dr. Hallie Blevins as she reviews pivotal data on ATTR-CM's expanding therapeutic landscape.

Host: Ryan Quigley An April 2025 Current Cardiology Reports article provides new insights into the role of cardiac magnetic resonance (CMR) and genetic data in diagnosing hereditary transthyretin amyloid cardiomyopathy (ATTR-CM). Learn more about this potential approach with Ryan Quigley in this AudioAbstract.

Presenter: Ryan Quigley Can real-time transepidermal water loss (TEWL) monitoring reduce the risk of anaphylaxis during oral food challenges in young children with peanut allergy? A pilot trial suggests it may. TEWL-guided stopping significantly lowered anaphylaxis rates and reaction severity without delaying treatment. This benefit was linked to earlier discontinuation of allergen exposure based...

Host: Ryan Quigley Distinct immune pathways in T2high and T2low asthma are shaping more precise therapies. To learn more, tune in as Ryan Quigley explores how endotype insights are guiding current and emerging immunotherapy strategies.

Host: Hallie Blevins, PhD For patients with multiple sclerosis (MS), cognitive impairment can quietly erode independence and quality of life. In this AudioAbstract, Dr. Hallie Blevins discusses a head-to-head comparison of cognitive training, aerobic exercise, and a combined approach and explores how we can better support cognition in these patients.

Host: Hallie Blevins, PhD A new analysis from the HEAR registry revealed that tafamidis is associated with significantly improved three-year survival in patients aged 80 and older with transthyretin cardiac amyloidosis (ATTR-CM). Hear from Dr. Hallie Blevins as she discusses this large real-world dataset and the importance of timely recognition and treatment of ATTR-CM in older patients—an often u...

Guest: Hallie Blevins, PhD In older patients with unexplained hypertrophy, the default diagnosis of hypertrophic cardiomyopathy (HCM) may overlook a common culprit: transthyretin amyloid cardiomyopathy (ATTR-CM). In this AudioAbstract, Dr. Hallie Blevins explores the TTRACK study, which uncovered a striking prevalence of ATTR-CM in patients previously labeled with HCM and affirmed the real-world r...

Host: Hallie Blevins, PhD A new preclinical study investigated whether Roseburia hominis , a gut microbe often depleted in individuals with obesity, could play a direct role in regulating metabolism. Learn more as Dr. Hallie Blevins explores these findings and their potential implications for future treatment of obesity and related metabolic disorders in this AudioAbstract .

Host: Ryan Quigley Artificial intelligence is reshaping the landscape of psoriatic arthritis, offering new tools to improve diagnosis, risk assessment, and treatment response prediction. Hear Ryan Quigley discuss a narrative review that looked at emerging AI innovations in rheumatology and how they may enhance care for patients with psoriatic arthritis.

Host: Ryan Quigley Distinguishing psoriatic arthritis from erosive hand osteoarthritis isn’t always straightforward—but a new imaging approach may help. Tune in to hear Ryan Quigley discuss a recent study assessing fluorescence optical imaging (FOI) and its potential to improve diagnostic accuracy in this challenging clinical scenario.

Host: Marlene Mimi Maeusli, PhD. Elderly patients with both aortic stenosis and transthyretin cardiac amyloidosis face complex management decisions, but new data suggest that combining aortic valve replacement (AVR) with ATTR-specific therapy may significantly improve outcomes. In this AudioAbstract , Dr. Mimi Maeusli reviews a multinational study published in the European Heart Journal on the pro...

Host: Ryan Quigley How are patients with breast cancer brain metastases faring in the modern treatment era? In this AudioAbstract, Ryan Quigley shares findings from a 25-year review of 507 patients at UCSF, providing new insights into how survival outcomes have shifted across subtypes and which treatments are driving real-world progress. This research was also presented at the 2025 San Antonio Bre...

Host: Ryan Quigley Triple-negative breast cancer (TNBC) remains one of the hardest subtypes to treat, with limited options and high relapse rates—so identifying new therapeutic targets is critical. In this AudioAbstract, Ryan Quigley spotlights research presented at the San Antonio Breast Cancer Symposium that implicates ribosome biogenesis as a key vulnerability. Tune in to learn how this approac...

Guest: Ryan Quigley At the 2025 American Society of Hematology Annual Meeting and Exposition, researchers presented key findings from the pivotal phase three CLL17 trial, which was the first randomized study to directly compare continuous BTK inhibition with fixed-duration venetoclax-based therapy in previously untreated chronic lymphocytic leukemia (CLL). Hear from Ryan Quigley as he shares new d...

Host: Ryan Quigley A cross-sectional study in Frontiers in Endocrinology assessed the triglyceride–glucose (TyG) index as a potential screening marker for prediabetes in children and adolescents with obesity. Hear from ReachMD's Ryan Quigley as he discusses the findings from this research and explores how the TyG index could provide an accessible tool for early risk stratification.

Host: Ryan Quigley New research presented at the 2025 American College of Rheumatology Convergence highlights a critical link between adverse childhood experiences and mental health outcomes in adolescents with childhood-onset systemic lupus erythematosus (cSLE). In this AudioAbstract, Ryan Quigley explores the findings, the implications for trauma-informed care, and the need to assess psychosocia...

Host: Ryan Quigley In a 2025 study investigating salivary metabolites as potential biomarkers in cystic fibrosis, researchers identified distinct metabolic patterns linked with key complications as well as correlations with lung function. In this AudioAbstract, Ryan Quigley discusses how a simple saliva sample could provide clinicians with an accessible, non-invasive tool to stratify patients, mon...

Host: Hallie Blevins, PhD. Early resistance to hydroxyurea in patients with polycythemia vera (PV) is associated with higher risks of thromboembolic complications, disease progression, and mortality. The PV-AIM study applied machine learning to real-world data and identified simple lab-based predictors that stratify patients by risk, and these findings were later validated in the HU-F-AIM trial. H...

Host: Ryan Quigley A new multicenter study highlights how serum and CSF biomarkers can refine prognostic accuracy and guide treatment strategies in multiple sclerosis (MS). ReachMD's Ryan Quigley explains key findings and provides insights on how integrating these biomarkers at diagnosis could move MS care toward more personalized and effective interventions. This topic was also discussed at the 2...

Host: Ryan Quigley In relapsed or refractory follicular lymphoma, disease control is only part of the equation. In this AudioAbstract, ReachMD's Ryan Quigley explores patient-reported outcomes from the ELM-2 trial, revealing that odronextamab not only delivers high response rates but also helps preserve—and in some cases, improve—quality of life.

Diagnosing long COVID continues to pose challenges for clinicians and patients alike. While 2024 diagnostic criteria from the National Academies aimed to make navigating it easier, the framework may raise some concerns, particularly for rheumatologists. Hear Ryan Quigley break down a commentary on the criteria published in July 2025 in Arthritis & Rheumatology that outlines why it may cause pr...

Host: Marlene Mimi Maeusli, PhD. New insights from DESTINY-Breast04 highlight how trastuzumab deruxtecan (T-DXd) not only extends survival but also delays symptom deterioration in HER2-low metastatic breast cancer. In this AudioAbstract, Dr. Mimi Maeusli discusses key takeaways from the outcomes analysis and what they mean for treatment planning and patient-centered care.

A secondary analysis of eight clinical trials assessed the efficacy of ubrogepant and atogepant in both acute and preventive migraine treatments. Dive into these findings and explore implications for the future of migraine care.