AMiNDR: A Month in Neurodegenerative Disease Research

In Part 3 of the August 2020 Risk Factors episodes, Naila will take you through research on how education and other cognitive factors can influence cognitive decline in later life, tell you about the positive effects of social and family support systems, and discuss papers that examine multiple risk factors at once, in an attempt to get a more complete picture of the complex genetic and environmen...

Judy is here to update you on the latest research on detecting amyloid and tau in the brain to diagnose AD in living patients, or to detect AD in post-mortem brain tissue.  This includes papers from August 2020 on the latest advances in PET and MRI imaging to detect these proteins, new tracers, and even a few papers on how amyloid and tau pathology may relate to cognitive decline and sex differenc...

In part 2 of our Risk Factors episodes for August 2020, Naila will go over papers on comorbidities associated with AD, hormonal factors that may explain some of the sex differences in AD risk, and how sleep relates to various aspects of AD. You’ll learn about various approaches to determining AD risk and prevalence in humans, and will also get a view of how the mechanisms of risk factors are studi...

Anusha updates you on the papers from August 2020 studying cognitive and behavioural changes that occur in Alzheimer's disease and how they relate to disease mechanisms and pathology. This includes research looking at people with AD or mild cognitive impairment, as well as animal models of this disease. Tune in to hear about all this interesting new research!  -------------------------------------...

Anusha is here to tell you about papers published in August 2020 on a range of topics in synaptic transmission, including changes to cholinergic signalling, glutamate signalling, synaptic plasticity, and connectivity in the context of AD. As well, she ends with a few papers that investigate sex differences in AD, which is very important in the context of studying disease mechanisms and developing...

Naila kicks off the August 2020 series of AMiNDR! This is part 1 of 3 of our episodes covering papers from this past August on risk factors for Alzheimer's disease. This includes the latest research on factors such as diet, weight, obesity, diabetes, and vascular disease, and how they may impact the risk of AD and memory decline. Enjoy this episode, and look out for many more coming out soon on th...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!   Ellen tells you about the papers on amyloid and tau detection in the brain, from June 2020! This includes studies on PET imaging in humans, PET and MRI imaging in animals, developing fluorescent and antibody probes, and more! Very interesting stuff, we hope you enjoy. This episode finishes off our series c...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!   In this episode, Sarah covers a wide array of papers on biomarkers in AD! You may have listened to our other episodes on this topic (blood and CSF biomarkers). This one gathers the papers that did not fit in those categories, and you're in for a treat:  TDP-43, C-reactive protein, epoxide hydrolase, cholin...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!   Elyn is back to cover other fluid biomarkers found in the CSF in AD, as well as biomarkers found elsewhere! You will hear about neurofilament light, hormones, synaptic markers, staging MCI... Some papers on imaging also somehow made it here (surprise).   Enjoy the episode and keep your eye out for more bio...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!   Elyn tells you  about papers on blood biomarkers for AD in this episode of AMiNDR! This includes a range of topics, including RNA biomarkers, neurofilament light, proteins biomarkers, and more! All of the papers are from June, 2020. Enjoy the episode and keep your eye out for more biomarker episodes coming...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!   In part 2, Bhumika tells you all about the new papers on imaging tools for AD from June 2020! You'll hear more about studies on using imaging technology such as MRI and PET to diagnose AD. If this is a topic that interests you, check out part 1 as well!  ----------------------------------------------------...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!   Sarah has a lot of fun hosting this highly interesting episode covering papers published in June 2020 on amyloid-beta-mediated toxicity in AD! We hope you enjoy, and that this update is useful for your research! If you're interested in papers on other mechanisms of amyloid-beta pathology in AD, check out e...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!   Bhumika tells you all about the new papers on imaging tools for AD from June 2020! You'll hear about tools for the prediction  of disease progression, the classification of AD, and the initial diagnosis of AD. New machine learning and bioinformatics tools for AD research and diagnosis are also covered in t...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!   Joseph tells you about more papers on drugs in development from June 2020.   These studies encompass those done in vitro or using computational models, but not animal testing. This episode brings together abstracts that were not sorted into a specific target cluster, so you will hear about a variety of tre...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!   In this episode, Sarah updates you on the papers from June 2020 that aim to refine or repurpose drugs and other treatments for Alzheimer's disease!  This includes studies on refining existing AD treatments, refining the method of delivery, and repurposing non-AD drugs for use in AD treatment. If you're int...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!   Joseph tells you about more papers on drugs in development from June 2020.   These studies encompass those done in vitro or using computational models, but not animal testing. Here, you will hear about approaches with multiple targets: cholinesterase, amyloid-beta, tau, oxidative stress...  If you're inter...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!   Ellen tells you about more papers on drugs in development from June 2020.   These studies encompass those done in vitro or using computational models, but not animal testing. This time around, she will be focusing on papers where the target is tau protein, the cholinergic system, metabolism, mitochondria,...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Ellen tells you about papers on drugs in development targeting amyloid-beta production, aggregation, and toxicity from June 2020!  If you're interested in hearing more about treatments for AD, you should also check out our episodes on pre-clinical and clinical testing.      To receive the list of papers cove...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, Marcia covers papers published in June 2020 on treatment development done on animal models, targeting metabolism, mitochondria, oxidative stress, the gut microbiome, inflammatory pathways, glia, and autophagy. If you are interested in learning more about these pathological events, you should...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, Naila covers papers published in June 2020 on treatment development done on animal models, targeting the cholinergic system, the glutamatergic system, synaptic function, tau, and amyloid-beta. If you are interested in this topic, you should check out our other episodes on this topic from the...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!  In this episode, Joseph presents papers published in June 2020 where pharmacological approaches and new compounds are tested on humans. You will hear about intranasal insulin, probiotics, Diclofenac, Crenezumab, and more.  If you are interested in this topic, you can also check our episodes on pre-clinical...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!  This episode is the second of two parts on the genetic landscape of AD! Here, Marcia will tell you about papers published this past June on sex differences, DNA methylation, some on transcriptomic, and more. Enjoy!   To receive the list of papers covered (with timestamps ), please fill this form:     ------...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! This episode is the first of two parts on the genetic landscape of AD! Here, Marcia will tell you about papers published this past June on the well-known AD-related genes PSEN-1 and APOE, as well as amyloid-beta related mutations, novel variants, and other variants/mutations. Enjoy!   To receive the list of...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!    Elyn will tell you all about papers from June 2020 on cerebrovascular changes and unclassified disease mechanisms in AD. We hope you enjoy!   To receive the list of papers covered (with timestamps ), please fill this form:     ------->  https://forms.gle/CVVbznAFM8pamdgk6  -------   or by tweeting at us:...

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!    In this episode, Naila will tell you about topics including intermittent fasting, musical interventions, young plasma treatment, and... hairy garlic, to name a few! She covers the papers in June 2020 that came out on non-pharmacological approaches for AD treatment. Enjoy the episode and feel free to reach...