Decoding Longevity

What if aging wasn’t a steady decline—but a mosaic of cellular behaviors? In this episode, we explore the complex biology of senescent cells with Dr. Iman Azimi, whose recent study using image-based single-cell profiling reveals an unprecedented diversity within these “zombie” cells. Together with hosts Dr. Raghav Sehgal and Dr. Macsue Jacques , we dive into: 🧬 The hidden heterogeneity of senesce...

We can now estimate your biological age from just a few drops of blood—but how close are we to using these tests in your doctor’s office? In this episode of Decoding Longevity , hosts Dr. Macsue Jaques and Dr. Raghav Sehgal sit down with Dr. Chiara Herzog , a molecular biologist and aging researcher at King’s College London, to unpack the translational bottlenecks holding back biomarkers of aging...

Can one gene reverse aging without the cancer risk? In this episode, we sit down with Dr. Lucas Paulo de Lima Camillo to discuss SB000—a single factor that could make cellular rejuvenation safer and more effective. Lucas walks us through the science behind this new preprint, how SB000 compares to the well-known OSKM cocktail, and what this could mean for the future of aging therapies. 🧬 Topics Co...

What if a single drop of blood could do more than tell your biological age? In this episode, we explore how cutting-edge epigenetic biomarker proxies and OMICmAge clocks can predict disease risk, personalize health interventions, and reshape how we approach aging itself. Our special guest, Dr. Varun Dwaraka , computational biologist and lead author of two groundbreaking papers, joins hosts Dr. Rag...

In this second part of our mind-expanding conversation with Peter Fedichev, co-founder of Gero, we explore what it will take to move longevity science forward. Peter argues that aging is a thermodynamic process — and that the loss of resilience begins before disease. So how can we detect that tipping point? And are mice really a dead end in anti-aging research? We also talk about: Why animal model...

Is aging just the sum of diseases, or is it something deeper? In this episode, we’re joined by physicist and Gero founder Peter Fedichev , who introduces a groundbreaking new framework: aging as a loss of thermodynamic stability . We explore: Why aging is a systemic phenomenon beyond individual pathologies How concepts from physics and complex systems can redefine longevity science The limits of c...

What if your DNA holds the key to your true biological age? In this episode of Decoding Longevity , hosts Raghav and Macsue talk with Prof. Nir Eynon to explore how DNA methylation helps us measure, understand, and potentially reverse aging. 🎙️ Based on: “Making Sense of the Ageing Methylome” – Nature Reviews Genetics (2022) 📌 Learn about epigenetic clocks, exercise as an epigenetic intervention,...

Aging isn’t just about getting older — it’s about how we age. In this episode, we explore the emerging science of biomarkers of aging : what they are, why they matter, and how they could transform the way we approach health and longevity. We’re joined by Jessi Poganik , PhD ( https://www.poganik.com/ ) — one of the authors of the paper “Biomarkers of Aging for the Identification and Evaluation of...

In this episode, Dr. Raghav Sehgal and Dr. Macsue Jacques dive into the hallmarks of aging Originally introduced in a groundbreaking 2013 paper by López-Otín, Blasco, Partridge, Serrano, and Kroemer, the Hallmarks of Aging outlined 9 key processes believed to drive the aging process. Fast forward to 2023, and the list has been expanded to 12, reflecting a decade of research and new insights into h...

What if slowing aging could save trillions of dollars and improve millions of lives? This episode breaks down The Economic Value of Targeting Aging , a study that quantifies the economic benefits of longevity interventions. We dive into the science, the numbers, and the real-world implications of investing in aging research.