The Scientist’s LabTalk

Synthetic technologies allow scientists to venture into uncharted waters, asking unique research questions and finding previously unattainable solutions to some of life’s biggest mysteries. From gene editing to protein engineering, synthesized DNA libraries enable researchers to grasp once unreachable high-throughput screening applications and dismantle barriers between experimental ideation and e...

Synthetic technologies allow scientists to venture into uncharted waters, asking unique research questions and finding previously unattainable solutions to some of life’s biggest mysteries. From gene editing to protein engineering, synthesized DNA libraries enable researchers to grasp once unreachable high-throughput screening applications and dismantle barriers between experimental ideation and e...

Synthetic technologies allow scientists to venture into uncharted waters, asking unique research questions and finding previously unattainable solutions to some of life’s biggest mysteries. From gene editing to protein engineering, synthesized DNA libraries enable researchers to grasp once unreachable high-throughput screening applications and dismantle barriers between experimental ideation and e...

With a track record of invention and translating technology into practical solutions, Walker Inman continues to drive innovation in the life sciences field. Inman is currently the cofounder and CEO of Lucid Scientific Inc., a company that develops cellular analysis tools.  In this Science Philosophy in a Flash podcast episode brought to you by Lucid Scientific, The Scientist spoke with Inman about...

Lauren Drouin is the director of analytical development and the Genomic Medicine Unit at Alexion AstraZeneca Rare Disease. As a dynamic scientist with unique expertise in current research and industry trends for gene therapies, Drouin is passionate about driving progress within the rare disease field and advancing products from preclinical development into the clinic and beyond.  In this Science P...

Researchers commonly employ lentiviruses to modify cells genetically. However, they must overcome several challenges when using these viruses in the laboratory or clinic. In this episode, Charlene Lancaster from The Scientist’s Creative Services Team spoke with Filippo Rossignoli, instructor in neurosurgery at the Center for Stem Cell and Translational Immunotherapy at Brigham and Women's Hospital...

Scientists continuously develop new assays to fill unmet diagnostic needs. While methods such as quantitative PCR have emerged as essential tools in molecular diagnostics, scientists developing and administering these assays still must overcome technical challenges. In this podcast series, The Scientist’s Creative Services Team talks to experts about their experiences designing and implementing as...

Scientists continuously develop new assays to fill unmet diagnostic needs. While methods such as quantitative PCR have emerged as essential tools in molecular diagnostics, scientists developing and administering these assays still must overcome technical challenges. In this podcast series, The Scientist’s Creative Services Team talks to experts about their experiences designing and implementing as...

Scientists commonly use qPCR applications in molecular diagnostics to detect pathogens, assess viral loads, or uncover mutations. While the qPCR assay itself may seem straightforward, other aspects such as data collection and security, and following regulatory guidelines, present challenges. In this episode, Gloria Lam, the associate director of qPCR software for Thermo Fisher Scientific, discusse...

Welcome to Molecular Diagnostics: An Eye Toward the Future, a special edition podcast series produced by The Scientist’s Creative Services Team. This series is brought to you by Thermo Fisher Scientific, a world leader in serving science. Their mission is to enable customers to make the world healthier, cleaner, and safer. Whether their customers are accelerating life sciences research, solving co...

Translational research cannot be conducted in a vacuum. For a translational researcher to be successful, they need to build strong relationships with individuals, companies, and institutions that will provide useful support and expertise. In this episode, Linda Mathiasson, Strategic Customer Leader for Nucleic Acid Therapeutics at Cytiva, discusses the flourishing translational field of mRNA thera...

In this episode, Guangping Gao, professor and director of the Horae Gene Therapy Center at the University of Massachusetts Medical School, speaks about developing human gene therapies using recombinant adeno-associated viral vectors, scaling up these therapies, and the future of translational research.   Welcome to Building Bridges for Translational Research, a special edition podcast series produ...

Welcome to Building Bridges for Translational Research, a special edition podcast series produced by The Scientist’s Creative Services Team. This series is brought to you by Cytiva, a global provider of technologies and services that advance and accelerate therapeutic development, manufacturing, and delivery. To take preclinical concepts to the market, translational researchers must build strong r...

Immunotherapies are promising as a holy grail for cancer treatment, but patient responses to these interventions are often variable in both solid tumors and blood cancers. In this episode, Iris Kulbatski from The Scientist’s Creative Services Team spoke with Olli Dufva, a physician and doctoral researcher at the University of Helsinki’s Hematology Research Unit, about his work analyzing the genomi...

Through epigenetic mechanisms, some environmental toxicants, such as heavy metals, reversibly alter gene expression patterns that then drive cancer progression. In this episode, Yvonne Fondufe-Mittendorf discusses her work studying environmental toxicants and their effects on DNA methylation and chromatin structure.   Welcome to Exposed: Environmental Echoes in Health, a special edition podcast se...

Substances that enter the body, such as food or chemicals, can make epigenetic changes in the germline that become inherited, affecting the health of future generations. In this episode, Heidi Lempradl discusses her work studying the effects of parental diet on their offspring.   Welcome to Exposed: Environmental Echoes in Health, a special edition podcast series produced by The Scientist’s Creati...

Welcome to Exposed: Environmental Echoes in Health, a special edition podcast series produced by The Scientist’s Creative Services Team. This series is brought to you by Van Andel Institute, an independent biomedical research institute devoted to improving human health for generations to come. While the human body’s cells all use the same set of instructions, they can end up with wildly different...

The brain’s intractable nature makes neurodegenerative disorders challenging to study, but modern assays and technologies give scientists a fresh look at this complex organ. In this episode, Niki Spahich from The Scientist’s Creative Services Team spoke with Erdem Gültekin Tamgüney, a professor in the Institute of Physical Biology at Heinrich Heine University Dusseldorf, about technologies driving...

As smart devices become commonplace in many homes, they also enter life science laboratories with the promise to enhance productivity, simplify collaborations, and produce reliable results. In this episode, Niki Spahich from The Scientist’s Creative Services team spoke with experts from MilliporeSigma about how smart devices change research for the better.   LabTalk is a special edition podcast pr...

Cancer immunotherapies are saving lives, but researchers still have a long journey ahead of them. Many cancers that are initially sensitive to immunotherapy acquire resistance over time, while others are resistant from the beginning. In this episode, Niki Spahich from The Scientist’s Creative Services team spoke with Stephanie Dougan, an associate professor of immunology at Harvard Medical School...

Childhood cancer is devastating. Every year over 15,000 children in the United States are diagnosed with cancer, with leukemia accounting for 28% of all childhood cancers in children under the age of 15. Leukemia, however, is not a single class of cancer. There are numerous forms of leukemia each with its own distinct cause.   In this episode, Tiffany Garbutt from The Scientist’s Creative Services...

A diverse population of microglial cells resides in the brain. Similar to immune cells, microglial cells respond to minute changes in their environment. Sometimes this response is beneficial and other times detrimental. Scientists are working to tease apart the dynamic role of microglial response in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease. In this episode, Tiffan...

The liver performs approximately 500 separate functions in the human body. With liver disease on the rise, scientists are developing treatments to save this irreplaceable organ. In this episode, Niki Spahich from The Scientist’s Creative Services team spoke with Prakash Ramachandran, a clinician scientist at the Centre for Inflammation Research at the University of Edinburgh, about mechanisms of s...

Motor neurons originating in the spine control both voluntary and involuntary movements. Even though they have an essential function, they are notoriously difficult to study. In this episode, Niki Spahich from The Scientist’s Creative Services team spoke with Jacob Blum, a graduate student in Aaron Gitler’s laboratory at Stanford University, about his work understanding the diversity of spinal mot...

Chimeric antigen receptor (CAR) T cell immunotherapies hold great promise for cancer treatment, but they are not very effective against solid tumors. Niki Spahich from The Scientist’s Creative Services team spoke with Katie McKenna, postdoctoral fellow in the laboratory of Malcolm Brenner at the Center for Cell and Gene Therapy at Baylor College of Medicine, about her work developing a combination...