Dove Medical Press podcasts

This podcast episode reviews recent advances in the treatment of IDH1-mutant acute myeloid leukemia (AML), focusing on the mechanisms, efficacy, and safety profiles of approved IDH1 inhibitors. The purpose is to present expert insights and clinical data from key trials that underscore the clinical benefits of these targeted therapies. Through discussion of key findings from pivotal clinical trial...

Acute myeloid leukemia (AML) is a heterogeneous malignancy characterized by diverse genetic mutations, including IDH1 and IDH2, which are present in approximately 15-20% of cases. Recent clinical practice guidelines, including the 2025 NCCN guidelines, emphasize the importance of comprehensive mutational profiling at diagnosis and at relapse to guide targeted treatment strategies for patients with...

Experts from Yale Cancer Center and MD Anderson Cancer Center describe the evolving landscape of molecular diagnostics in acute myeloid leukemia (AML). The discussion traces the shift from morphology- and immunophenotype-based classification to genomics-driven stratification, catalyzed by advancements in next-generation sequencing (NGS). Discussants emphasize the clinical importance of identifying...

Generalized pustular psoriasis (GPP) is a rare, chronic, inflammatory skin disease characterized by persistent symptoms and sudden flares of painful, sterile pustules, and may be accompanied by systemic inflammation. Ongoing symptoms of GPP can have a serious impact on patient quality of life, morbidity, and mortality, and severe flares may be life-threatening if left untreated. Guidelines have be...

Dr Uwe Wollina, the former head of the department of dermatology and allergology at the Academic Teaching Hospital, Dresden welcome Drs. Merola and Amin to discuss the potential triggers of an acute GPP flare. GPP can be debilitating for patients, and they will discuss the different aspects of the burden of disease for patients with GPP. Generalized pustular psoriasis (GPP) is the most severe form...

Dr Jason Hawkes, a board-certified medical dermatologist in the Greater Sacramento area welcomes Drs. Bhutani and Reisner, to discuss the clinical presentation of GPP, the patient journey, diagnostic challenges, and novel management strategies from the perspective of the patient and provider. Generalized pustular psoriasis (GPP) is a rare, chronic, and debilitating disease characterized by flares...

Dr Stanley Cohen, the Department of Internal Medicine, University of Texas Southwestern Medical Center, and Mariah Z. Leach, Mamas Facing Forward, Colorado, discuss some of the queries and concerns that patients may have about initiating or switching to treatment with a biosimilar for rheumatoid arthritis following the US 2023 release of several biosimilars of the adalimumab reference product, als...

Dr Uwe Wollina, the head of the department of dermatology and allergology at the Academic Teaching Hospital, Dresden welcome Drs. Clive Liu and Eingun James Song, who are both dermatologists in Washington State to discuss their experiences in treating generalized pustular psoriasis, also referred to as GPP. Acute episodes of generalized pustular psoriasis (GPP), known as “flares,” are characterize...

Dr Uwe Wollina, the head of the department of dermatology and allergology at the Academic Teaching Hospital, Dresden welcome Drs. Bhutani and Hawkes, both board-certified dermatologists in California to discuss their experiences in treating generalized pustular psoriasis, also referred to as GPP. Generalized pustular psoriasis is a rare presentation of psoriatic disease and is characterized by the...

Dr John Kane, discusses negative symptoms in schizophrenia alongside fellow expert, Dr William Carpenter, and Mr Matthew Racher, a Certified Recovery Peer Specialist and dedicated advocate for people living with schizophrenia, who is currently studying for his Master of Social Work (MSW) in Miami, Florida. In this podcast, the authors discuss challenges and opportunities faced by patients and clin...

Dr John Kane, a clinical expert in schizophrenia, discusses cognitive impairments in schizophrenia with fellow expert Dr Philip D. Harvey and patient advocate and mental health clinician, Mr Carlos Larrauri, who was diagnosed with schizophrenia. The podcast aims to raise awareness of the unmet need to address cognitive impairments associated with schizophrenia (CIAS) as well as the challenges/oppo...

In the final episode of Season 4, Dr Surya Bhatt is here to discuss the influence of continued smoking on COPD with Dr Richard Russell. They will discuss how smoking can impact treatment decisions, how we can get our patients to stop smoking and the effects smoking can have on COPD outcomes.1–3 Dr Russell will then dive into a new publication on the impact of air quality on exacerbations during th...

Dr Richard Russell is joined this week by Professor James Chalmers, the Asthma and Lung UK Chair of Respiratory Research at the University of Dundee, Scotland, and Honorary consultant physician at Ninewells Hospital, to discuss the role of the lung microbiome in respiratory disease and the influence it may have on the management of COPD.1–3 Dr Russell will then share insights from an interesting n...

Dr Richard Russell is joined this week by Professor David Newby, the Chair of Cardiology at the University of Edinburgh, Scotland, to discuss the overlap between COPD and cardiovascular disease in clinical practice. Listen as they explore the similarities between risk factors and patient presentation, which treatments are the most effective, and how cardiologists and respiratory physicians can wor...

This week's guest on the Medical Insider COPD podcast is Professor Eric Bateman, a Chest Physician and Professor of Respiratory Medicine at the University of Cape Town, South Africa. Join him and Dr Richard Russell as they discuss the barriers impeding implementation of global COPD recommendations in low- and middle-income countries (LMICs) and how global guidelines might better cater to LMICs,1,2...

In this episode of the Medical Insider COPD podcast, Dr Richard Russell is joined by Professor Sinthia Bosnic-Anticevich to explore the importance of inspiratory effort in COPD. 1 They will discuss the different types of inhalers available, the impact of suboptimal inspiratory effort on the management of COPD and the key considerations for clinicians when prescribing an inhaler. 2–4 Dr Russell wil...

Dr Richard Russell is joined by Professor Antonio Anzueto in this episode of the Medical Insider COPD podcast to talk about real-world evidence and the gaps it can fill in the world of COPD research. Listen as they compare the finding from randomised controlled trials with real-world data and discuss how guidelines can be implemented in clinical practice. 1-3 Dr Russell will also highlight a new a...

To begin this episode of the Medical Insider COPD podcast, Dr Richard Russell is joined by Professor James Chalmers once more to delve into the topic of bronchiectasis. Specifically, they will be discussing how patients with bronchiectasis compare with patients with COPD, what treatments are the most appropriate and what the guidelines recommend. 1–3 Dr Russell also presents a new publication look...

On the Medical Insider COPD Podcast this week, Dr Richard Russell is joined by Professor MeiLan Han from the University of Michigan in the United States. She will be discussing early COPD and how imaging can play a role in the diagnosis and management of COPD. 1-3 Listen as she explores the benefits of identifying COPD earlier in the course of the disease as well as in younger patients, 1,2 delvin...

This episode’s guest on the Medical Insider COPD podcast is Dr Barbara Yawn, a primary care physician and COPD clinical researcher. Join her and Dr Richard Russell as they explore the impact of breathlessness from the patient perspective, discussing physical activity, pharmacotherapy and mortality. 1-4 Dr Russell will then present the key takeaways from a new and exciting publication on the real-w...

In this episode of the Medical Insider COPD podcast, Dr Richard Russell is joined by Dr Brad Drummond to discuss the topic of inhaler adherence in COPD. They will explain the factors that affect device adherence, how we can improve adherence in our patients, and the impact adherence can have on COPD outcomes. 1,2 Dr Russell will also delve into a newly released publication on necroptosis and emphy...

Dr Marc Miravitlles is back to discuss mortality analyses with Dr Richard Russell.1 They will review what the guidelines recommend for initial and follow-up treatment of COPD, who should receive inhaled corticosteroids and how we should interpret mortality analyses in the COPD field.2–4 Dr Russell will then dive into a new publication on the use of FEV3/FEV6 in early airways disease identification...

On this episode of the Medical Insider COPD podcast, Professor Jadwiga Wedzicha joins Dr Richard Russell to discuss the importance of early intervention in COPD.1 She will explore the use of optimised bronchodilation to improve early symptoms and physical activity,1,2 what the guidelines recommend when treating patients with milder disease,3 and how HCPs can start making a difference earlier.4 Dr...

Join Dr Richard Russell and Professor Samy Suissa for the first episode of Season 4, as they discuss the importance of study design in the interpretation of COPD clinical trials.1,2 Listen as the experts examine the outcomes of well-known triple therapy studies and the consequences they may have for clinical practice.3,4 Dr Russell will also share highlights from a recent publication on the impact...

Professor Arschang Valipour is this week’s expert guest on the Medical Insider COPD podcast. Join him and Dr Richard Russell as they discuss the role of phenotyping in patients with COPD and how it could influence management decisions. 1,2 A new publication on the use of low-dose morphine for chronic breathlessness will be discussed by Dr Russell,3 alongside the effects of winter weather on respir...