SetSet with April Pride

126. Psychedelics & Addiction: What the Research Shows Addiction psychiatrist Dr. Nathan Sackett on psilocybin, ibogaine, MDMA, ketamine, and what psychedelic-assisted therapy can and cannot do for substance use disorder. Episode Summary The conversation about psychedelics as addiction treatment is moving faster than the research. Dr. Nathan Sackett is trying to close that gap. Founding director o...

125. The Wise Body: What Women's Hormones, Cycles, and Lived Experience Have to Teach Psychedelic Medicine Stephanie Karzon Abrams of Galilea on why psychedelic care must account for women's cycles, life stage, and the knowledge that predates clinical trials. Episode Summary The research on psychedelics was built around male bodies. Women were treated as a confounding variable — their cycles, horm...

124. Psychedelic Integration and Intuition: What Actually Changes After Ayahuasca Explore psychedelic integration and intuition through ayahuasca, grief, and leadership. What really changes after plant medicine? Episode Summary What actually happens after the ceremony ends? In this episode, April sits down with Lizzi Cutler to explore psychedelic integration and intuition beyond the peak experienc...

123. Microdosing for Midlife: Emotional Resilience(Week 6) Week 6 explores extinction learning, emotional resilience, and how microdosing may support gradual rewiring of fear-based patterns in midlife. Episode Summary This episode is part Week 6 of Microdosing for Midlife —a 12-part audio companion to the original Substack series. In this conversation, April explores emotional resilience not as to...

122. Microdosing for Midlife: Stability & Nervous System Change (Week 5) Week 5 explores masking, authenticity, the Default Mode Network, and how microdosing may soften rigid self-narratives in midlife. Episode Summary This episode is part Week 5 of Microdosing for Midlife —a 12-part audio companion to the original Substack series. In this conversation, April explores authenticity not as a dramati...

121. Microdosing for Midlife: Stability & Nervous System Change (Week 4) Week 4 of Microdosing for Midlife explores how nervous system stability shapes identity, growth, and long-term change in midlife. Episode Summary This episode is part Week 4 of Microdosing for Midlife —a 12-part audio companion to the original Substack series. In this conversation, April expands on what it actually means to f...

120. Microdosing for Midlife: Hormones, Perception, and Libido (Week 3) Exploring how menopause, perception shifts, and nervous system regulation intersect with midlife libido. Episode Summary This episode continues Week 3 of Microdosing for Midlife , April Pride’s 12-part audio companion to her Substack series exploring microdosing through the lens of midlife transition. In this conversation, Apr...

119. Microdosing for Midlife: Brain Science of Change (Week 2) Week 2 of Microdosing for Midlife explores estrogen, menopause, hormone therapy, and cognitive health—plus how psilocybin supports neuroplasticity. Episode Summary This episode marks Week 2 of Microdosing for Midlife , a 12-week audio series exploring how psilocybin microdosing for women intersects with hormonal change, emotional regul...

118. Microdosing for Midlife: Intention Setting, Integration, and Finding Your Dose (Week 1) Week 1 of Microdosing for Midlife explores intention setting, finding the right microdose, and integrating psilocybin gently during midlife transitions. Episode Summary This episode marks Week 1 of Microdosing for Midlife , a 12-week audio series exploring how psilocybin microdosing for women can support e...

117. Ibogaine Therapy Safety & Ethics: What Responsible Care Really Looks Like A grounded conversation on ibogaine therapy safety and ethics —covering medical oversight, risks, integration, and responsible psychedelic care. Episode Summary Ibogaine is often described as a breakthrough for addiction, trauma, and PTSD—but it’s also one of the most medically complex psychedelic therapies in use today...

116. Psychedelics and Aging: Meaning in Later Life An educational conversation on psychedelics and aging , exploring meaning-making, grief, safety, and integration through lived experience and research. Episode Summary What happens when psychedelic experiences arrive later in life—after careers, caregiving, grief, and loss have already shaped the nervous system? In this episode, April Pride sits d...

115. 5-MeO-DMT Experience Explained A grounded conversation on the 5-MeO-DMT experience—how it affects the nervous system, how it differs from DMT, and why safety and integration matter. Episode Summary What is 5-MeO-DMT , and why do people describe it so differently from other psychedelics? In this episode, April Pride sits down with licensed clinicians and facilitators Roger and Dustin to explor...

114. How to Start Microdosing with Psilocybin A science-backed guide to microdosing psychedelics with SetSet’s 12-week protocol, featuring expert insight and lived experience. Episode Summary If you’ve been microdose-curious — or maybe you’re already experimenting and want a little more structure — this episode is your map. Host April Pride pulls together insights from SetSet collaborators includi...

113. Psychedelic Law in Seattle: What’s Actually Legal in 2025? SetSet Salon breaks down psychedelic law in Seattle with attorneys Perry Salzhauer & Daniel Shortt—what the entheogen resolution covers, what it doesn’t, and the risks it creates. Episode Summary Most people think Seattle has legalized psychedelics. It hasn’t—at all. In this episode, recorded live at SetSet’s Psychedelic Salon at Town...

112. Epidemic of Fear: How Psychedelics Help Us Transcend Stuckness Discover how psychedelics help retrain the nervous system to move from fear to flow. April Pride explores the roots of stuckness, the Hero’s Journey, and how microdosing and macrodosing support nervous system healing. 🔵 What You’ll Learn - Why fear is the defining epidemic of our time —and how it paralyzes potential. - How Tradit...

111. Trip Report: Kanna vs. MDMA Plus How Molly Effs With Your Sleep For Weeks What if you could feel more connected, relaxed, and joyful—without alcohol or MDMA? In this episode, I talk to Andrew Weisse, founder of getKanna and writer of Substack's The Psychedelic Blog, about the mood-enhancing, heart-opening power of Kanna , a South African plant that’s gaining popularity as a functional empatho...

110. How to Rethink Drinking Without "Hitting Rock Bottom" What if your relationship with alcohol doesn’t require a dramatic rock-bottom moment to change? In this episode of SetSet, I sit down with sobriety coach Martha Wright, who went from building a life around wine—professionally and personally—to questioning its role in her daily rituals. Just as I did with cannabis. Together, Martha and I ex...

How MDMA Is Transforming Love, Aging & Grief Many people think MDMA is a party drug. What if it’s actually a medicine for seniors? Episode 111 of the SetSet Podcast. Join us for this deeply personal, science-backed live recording of our August virtual Psychedelic Salon. I was joined by Charley Wininger, licensed therapist and author of Listening to Ecstasy , and his wife Shelly, who introduced Cha...

109. How Psilocybin Microdosing Supports Menopause: A Brain-Based Guide How can women navigate the emotional, cognitive, and hormonal rollercoaster of perimenopause and menopause? In this episode, April Pride explores how psilocybin microdosing may offer real support for women in midlife . From balancing neuroplasticity and mood to improving sexual function and breaking addictive patterns, this co...

108. Why Bong Design Matters for Modern Women: Esther Ramirez from Session Goods What if your bong could live on your coffee table—without shame or splashback? In this 4/20 Easter special, April Pride sits down with Esther Lenore Ramirez, co-founder and CEO of Session Goods, to explore how minimalist bong design supports women who want elegant, intentional tools for cannabis . From design trade-of...

107. Psilocybin for Menstrual Cycles and Menopause: A Women’s Wellness Protocol How can mushrooms sync with your cycle—or shift your experience of menopause? In this episode, April Pride is joined by Jennifer Chesak, author of The Psilocybin Handbook for Women , to decode the powerful relationship between psilocybin and women’s hormones . Together, they explore the latest research, ancestral wisdo...

106. Natural Psychedelics and the Healing Power of Community What if the most potent medicine isn’t just the mushroom or the ceremony—but the community that holds you through it? In this soul-stirring conversation, host April Pride continues her dialogue with healer and teacher Satya on the role of natural psychedelics in helping women heal trauma and reconnect with their core selves . From the ro...

105. Integrating Science and Spirituality: A New Framework for Psychedelic Healing What does it mean to truly heal in a psychedelic space? In this episode, host April Pride is joined by Satya—a seasoned facilitator whose work bridges psychotherapy, meditation, and natural psychedelic therapy. Together, they unpack how conscious language, sacred space, and personalized protocols shape transformativ...

104. How Microdosing for Women Rewires Habit, Hormone, and Healing Cycles How does a microdose change a life? In this powerful conversation, April Pride returns with part two of her interview with guide Sand Symes to unpack what really happens when women begin a psychedelic microdosing protocol . From rewiring somatic patterns to clearing menopausal brain fog, this episode explores how subtle shif...

103. Feminine Psychedelic Power: Healing Stories from the Inside Out In this soulful and story-rich episode, April Pride welcomes Sand Symes, a guide with decades of experience guiding women through psychedelic journeys. Together, they explore how feminine energy—when supported by plant medicine like psilocybin , cannabis , and MDMA —can become a powerful portal to emotional liberation and embodie...