Machine Learning Street Talk (MLST)

Tim Scarfe travels to Zurich to sit down with the Tufa Labs ARC-AGI-3 team — founder Benjamin Crouzier, with Jeroen Cottaar, Dries Smit, Stefano Viel and Michal Tesnar — to work out what their leaderboard-topping system does and what the benchmark is really testing. The cut opens on the games: a walkthrough of the Locksmith game, where you read the rules of an unfamiliar world straight from raw fr...

Thomas Ahle wants Normal Computing to be the Lovable for chip design: type your intent, and a swarm of agents carries it from design through optimisation, formalisation and verification to tape-out. To get there, his team at wrote their own open-source Verilog simulator, 580,000 lines in 43 days, because commercial EDA verifiers run about $10,000 per core and there are no decent open-source compil...

This episode is sponsored by Notion. Learn more about Notion's Developer Platform today at https://notion.com/mlstProtein folding stalled biology for fifty years. A sequence of amino acids dictates a three-dimensional shape, but reading that shape meant a year and roughly $100,000 of crystallography per structure. Then AlphaFold 2 won CASP14 so decisively the organizers called the problem esse...

Brad Carson was the Army's General Counsel, served two terms in Congress and was Acting Under Secretary of Defense for Personnel and Readiness. He now heads Americans for Responsible Innovation, the AI-policy advocacy group he co-founded. Keith Duggar spends roughly eighty minutes pushing back. SPONSOR: --- Cyber Fund built the Monastery to help founders ship products that were impossible a year a...

Michael I. Jordan, described by Science magazine as the most influential computer scientist alive, has never thought of himself as an AI researcher. In this conversation he explains why that distinction matters. SPONSOR: --- Cyber Fund built the Monastery to help founders ship products that were impossible a year ago. Applications for Batch 1 are now open. Apply now: https://cyber.fund --- Jordan...

Beth Barnes and David Rein on the one graph that ate the AI timelines discourse, and why the two people who built it are the most careful about how you read it.**SPONSOR**Prolific - Quality data. From real people. For faster breakthroughs.https://www.prolific.com/?utm_source=mlstInterview: https://youtu.be/cnxZZTl1tkk---Beth Barnes and David Rein from METR on the one graph that ate the AI timeline...

Robert Lange, founding researcher at Sakana AI, joins Tim to discuss *Shinka Evolve* — a framework that combines LLMs with evolutionary algorithms to do open-ended program search. The core claim: systems like AlphaEvolve can optimize solutions to fixed problems, but real scientific progress requires co-evolving the problems themselves. GTC is coming, the premier AI conference, great opportunity to...

Dive into the realities of AI-assisted coding, the origins of modern fine-tuning, and the cognitive science behind machine learning with fast.ai founder Jeremy Howard. In this episode, we unpack why AI might be turning software engineering into a slot machine and how to maintain true technical intuition in the age of large language models. GTC is coming, the premier AI conference, great opportunit...

What if life itself is just a really sophisticated computer program that wrote itself into existence? Blaise Agüera y Arcas presenting at ALife 2025 — the most technically detailed public walkthrough of the ideas in his *What is Life?* and *What is Intelligence?* books that we've come across. He covers the BFF experiments (self-replicating programs emerging spontaneously from random noise), th...

What makes something truly *intelligent?* Is a rock an agent? Could a perfect simulation of your brain actually *be* you? In this fascinating conversation, Dr. Jeff Beck takes us on a journey through the philosophical and technical foundations of agency, intelligence, and the future of AI. Jeff doesn't hold back on the big questions. He argues that from a purely mathematical perspective, there...

Professor Mazviita Chirimuuta joins us for a fascinating deep dive into the philosophy of neuroscience and what it really means to understand the mind.*What can neuroscience actually tell us about how the mind works?* In this thought-provoking conversation, we explore the hidden assumptions behind computational theories of the brain, the limits of scientific abstraction, and why the question of ma...

What if everything we think we know about the brain is just a really good metaphor that we forgot was a metaphor? This episode takes you on a journey through the history of scientific simplification, from a young Karl Friston watching wood lice in his garden to the bold claims that your mind is literally software running on biological hardware. We bring together some of the most brilliant minds we...

Dr. Jeff Beck, mathematician turned computational neuroscientist, joins us for a fascinating deep dive into why the future of AI might look less like ChatGPT and more like your own brain. **SPONSOR MESSAGES START** — Prolific - Quality data. From real people. For faster breakthroughs. https://www.prolific.com/?utm_source=mlst — **END** *What if the key to building truly intelligent machines isn't...

Tim sits down with Max Bennett to explore how our brains evolved over 600 million years—and what that means for understanding both human intelligence and AI. Max isn't a neuroscientist by training. He's a tech entrepreneur who got curious, started reading, and ended up weaving together three fields that rarely talk to each other: comparative psychology (what different animals can actually...

César Hidalgo has spent years trying to answer a deceptively simple question: What is knowledge, and why is it so hard to move around? We all have this intuition that knowledge is just... information. Write it down in a book, upload it to GitHub, train an AI on it—done. But César argues that's completely wrong. Knowledge isn't a thing you can copy and paste. It's more like a living org...

This is a lively, no-holds-barred debate about whether AI can truly be intelligent, conscious, or understand anything at all — and what happens when (or if) machines become smarter than us. Dr. Mike Israetel is a sports scientist, entrepreneur, and co-founder of RP Strength (a fitness company). He describes himself as a "dilettante" in AI but brings a fascinating outsider's perspecti...

We often think of Large Language Models (LLMs) as all-knowing, but as the team reveals, they still struggle with the logic of a second-grader. Why can’t ChatGPT reliably add large numbers? Why does it "hallucinate" the laws of physics? The answer lies in the architecture. This episode explores how *Category Theory* —an ultra-abstract branch of mathematics—could provide the "Periodic Table" for neu...

Is a car that wins a Formula 1 race the best choice for your morning commute? Probably not. In this sponsored deep dive with Prolific, we explore why the same logic applies to Artificial Intelligence. While models are currently shattering records on technical exams, they often fail the most important test of all: **the human experience.** Why High Benchmark Scores Don’t Mean Better AI Joining us a...

What if everything we think we know about AI understanding is wrong? Is compression the key to intelligence? Or is there something more—a leap from memorization to true abstraction? In this fascinating conversation, we sit down with **Professor Yi Ma**—world-renowned expert in deep learning, IEEE/ACM Fellow, and author of the groundbreaking new book *Learning Deep Representations of Data Distribut...

Pedro Domingos, author of the bestselling book "The Master Algorithm," introduces his latest work: Tensor Logic - a new programming language he believes could become the fundamental language for artificial intelligence. Think of it like this: Physics found its language in calculus. Circuit design found its language in Boolean logic. Pedro argues that AI has been missing its language - un...

The Transformer architecture (which powers ChatGPT and nearly all modern AI) might be trapping the industry in a localized rut, preventing us from finding true intelligent reasoning, according to the person who co-invented it. Llion Jones and Luke Darlow, key figures at the research lab Sakana AI, join the show to make this provocative argument, and also introduce new research which might lead the...

Ever wonder where AI models actually get their "intelligence"? We reveal the dirty secret of Silicon Valley: behind every impressive AI system are thousands of real humans providing crucial data, feedback, and expertise. Guest: Phelim Bradley, CEO and Co-founder of ProlificPhelim Bradley runs Prolific, a platform that connects AI companies with verified human experts who help train and e...

"What is life?" - asks Chris Kempes, a professor at the Santa Fe Institute. Chris explains that scientists are moving beyond a purely Earth-based, biological view and are searching for a universal theory of life that could apply to anything, anywhere in the universe. He proposes that things we don't normally consider "alive"—like human culture, language, or even artificial...

Blaise Agüera y Arcas explores some mind-bending ideas about what intelligence and life really are—and why they might be more similar than we think (filmed at ALIFE conference, 2025 - https://2025.alife.org/). Life and intelligence are both fundamentally computational (he says). From the very beginning, living things have been running programs. Your DNA? It's literally a computer program, and...

We sat down with Sara Saab (VP of Product at Prolific) and Enzo Blindow (VP of Data and AI at Prolific) to explore the critical role of human evaluation in AI development and the challenges of aligning AI systems with human values. Prolific is a human annotation and orchestration platform for AI used by many of the major AI labs. This is a sponsored show in partnership with Prolific. **SPONSOR MES...