Longevity Roadmap

Scary news last week when Bronny James, the 18 year old son of Lebron and Savannah James collapsed during a workout at USC. It has been reported that James suffered a cardiac arrest. In September 2022 another seemingly healthy and fit USC basketball player, Vince Iwuchukwu also suffered cardiac arrest.  Thankfully USC was prepared and in both cases they were able to get these young athlete's heart...

Buck and Alan Viglione, MD discuss the Cardio IQ® report in detail and battle it out to see has the best numbers in this 2 part episode. Part 2 will drop as Episode 22. 0:01:31 - What exactly is a Cardio IQ? 0:03:15 - the cost of Cardio IQ 0:05:18 -Lipid panel, Total Cholesterol, HDL, Triglycerides, LDL Cholesterol 0:08:29 - HDL the so-called good cholesterol 0:13:55 - Lipoproteins 0:15:42 - LDL P...

In this episode Buck discusses snoring and sleep apnea and why they should be taken seriously. 0:01:17 - Snoring And Sleep Apnea 0:01:45 - Up To 20% Of The Population Has Clinically Relevant Sleep Apnea 0:02:52 - Central Sleep Apnea 0:03:12 - Obstructive Sleep Apnea 0:03:34 - Sleep Apnea Is The Enemy Deep Sleep 0:03:59 - Increased Risk Of Diseases Associated With Sleep Apnea 0:05:32 - Sleep Apnea...

Buck talks with GRAIL President Josh Ofman, MD, MSHS, about their groundbreaking Multi-cancer early detection (MCED) technology and it's promise as a significant new tool in the war on cancer. 0:00:00 - Advancements in Cancer Detection Technology 0:00:35 - GRAIL Galleri test 0:02:11 - About Dr. Josh Ofman 0:05:14 - Cancer really is a disease of the genome 0:12:35 - Various guidelines for early det...

In this Sapio Short Buck discusses the news last week that the World Health Organization (WHO) has declared the artificial sweetener Aspartame a "a possible carcinogen". So what does this classification mean for you and how worried should you be? 0:00:13 - World Health Organization classified aspartame as a possible carcinogenic substance 0:02:03 - Group 2B - the possibly carcinogenic to humans ca...

In this episode, Alan Viglione, MD joins Buck to answer some of our audience questions. 0:01:08 - How To Prevent The Dawn Phenomenon Or Rise Of Sugar Levels During Sleep Or Early Morning 0:04:44 - Hemoglobin A1C 0:08:00 - What Is Gluconeogenesis?  0:14:24 - Managing Dawn Phenomenon  0:18:04 - A Question About Geroprotectant Supplements 0:19:37 - Nicotinamide Riboside As A Precursor to NAD+ 0:26:02...

In this episode Buck continues his conversation with Rob Hamilton MD from Prestige Regenerative Medicine - this time discussing Female Hormone Replacement. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal. 0:01:14 - Overview Of Some Of The Hormonal Issues That Women Go Through Throughout Their Life 0:03:33 - Average Age When Women Experience...

Buck discusses Male Hormone Replacement with Rob Hamilton, MD from Prestige Regenerative Medicine. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal. Human Growth Hormone is also discussed in this hour-long discussion.  0:00:12 - Rob Hamilton's Background  0:04:44 - What Happens With These Kinds Of Male Sex Hormones Over Time? 0:05:46 - Decli...

In part two of a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics. 0:00:29 - What Is Psilocybin? 0:01:42 - The Serotonergic Effects Of Psilocybin  0:04:08 - Exploring The Effects Of Microdosing Psilocybin 0:09:16 - Microdosing And Euphoria 0:12:03 - Exploring Psychedelic Microdosing 0:15:31 - The Fadiman Protocol 0:17:10 - The Stamets Protocol 0:19:59 - Microdo...

In this is a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics. Part 2 will be online for our regular Wednesday episode drop. 0:00:39 - About Dr. Michael Mantz 0:02:47 - Studying With Famous Herbalists In Utah 0:06:46 - Dr. Mantz's Integrative Approach Combining Nutrition, Exercise And Supplements 0:08:21 - Dr. Mantz's Current Practice: The Santa Barbara Integra...

Buck discusses studies on the effect of saunas for overall health and longevity. 0:01:35 - What's The Big Deal With Saunas? 0:02:03 - Kuopio Ischemic Heart Disease Study 0:04:44 - Sauna Benefits For The Body 0:04:53 - Heat Shock Proteins 0:07:30 - Increased Expression Of Brain Derived Neurotrophic Factor 0:09:05 - Saunas And Longevity 0:11:08 - Blood Glucose Spikes While In The Sauna 0:12:19 - Opt...

Buck and Montecito Concierge Medicine's Alan Viglione explore compelling studies revealing the profound impact of social connections on our longevity. Join us as we uncover the fascinating evidence that demonstrates how fostering relationships can unlock the secret to a longer, more fulfilling life. 0:00:09 - Last Pillar Of Longevity: Social Relationships 0:01:11 - Tribal Societies And The Common...

Buck discusses with Executive Producer Ben Hyatt a study that appeared June 9th, 2023 in Science magazine that linked Taurine with healthy aging and increased lifespan in animal studies.   0:01:30 What we knew about Taurine before the study. 0:03:22 What is Taurine? 0:03:39 What new information did we learn from the study? 0:06:30 Why do multiple models matter when it comes to studies? 0:07:04 Wha...

Shownotes: 1:02 What is Diagnostics when it comes to medicine? 2:35 What are some of the traditional Diagnostics used in Medicine 2.0? 4:11 - Summarize the basic screenings you should be getting starting at based on Medicine 2.0 guidelines 6:09 Why are PSA screenings controversial? 8:19 - Cardiovascular testing - medicine 2.0 8:53 - Medicine 3.0 9:26 What's a Cardio IQ? 18:10 Genetic Screening 19:...

Shownotes: 0:01:04 Metformin and Diabetes 0:02:48 Metformin Monotherapy 0:06:46 Are There Any Geroprotective Benefits From Taking Metformin? 0:10:50 Benefits of Rapamycin and 0:12:14 Acarbose and Sugar Metabolism 0:16:28 SGL2 inhibitor Jardiance 0:20:37 Glucose Monitoring and Metformin

Shownotes: 0:01:54 Geroprotective Medication 0:09:51 Addressing Fear Of Medication 0:12:22 Preventing Cardiovascular Disease 0:15:27 PCSK9 Inhibitors 0:16:48 Cardio IQ Test 0:17:02 Cardiac Risk Algorithm 0:21:10 Metformin 0:26:09 Interventions Testing Program (ITP) 0:27:32 Rapamycin 0:29:52 Acarbose 0:31:46 Invokana 0:39:29 NMN Supplementation  

Shownotes: 0:01:31 The Importance Of Sleep For Health 0:03:41 Rapid Eye Movement (REM) Sleep 0:03:57 Non-REM Sleep 0:06:22 Sleep Problems and Links to Alzheimer's and Dementia 0:08:14 Glial–Lymph and Deep Sleep 0:10:14 REM Sleep And Brain Health 0:14:28 Sleep Apnea: Berlin questionnaire and STOP-Bang assessment 0:17:04 Oura Ring 0:17:57 Sleep Disruption and Cancer 0:23:26 Night Shift Work And Heal...

Our understanding of how to get the most out of exercise has evolved. A combination of cardio training with weight training can have a profound effect on longevity and quality of life. Learn how to get the most out of your exercise and what metrics you can track to measure your fitness! Shownotes: 0:00:33 Hormesis and Challenging the Body 0:02:48 The Benefits Of Exercise 0:04:07 The Cardiovascular...

In this bonus Q&A episode Buck Joffrey dives a little deaper into one of the key Episode 2 topics - blood glucose and how it affects your body with Sapio Executive Producer Ben Hyatt. Shownotes: 0:01:36 Understanding Glucose and Insulin Interaction 0:06:19 Food Combinations and Blood Sugar 0:10:56 Understanding Diabetes and Glycation 0:16:13 Diabetes and Testing

There is more to healthy eating than calories in and calories out. Learn the new science around eating to extend life including what to eat and when! Shownotes: 0:00:03 Pillars of Longevity: Diet and Nutrition 0:04:29 Caloric Restriction and Timing of caloric intake 0:09:29 Impact of Carbs on Intermittent Fasting 0:18:46 Managing Blood Sugar and Identifying Pre-Diabetes 0:19:49 The Importance of H...

An Introduction to the pillars on longevity and underlying science. Buck talks with Montecito Concierge Medicine's Alan Viglione. Shownotes: 0:00:31 Introduction to Sapio 0:03:53 Pillars of Longevity 0:04:17 Food and Nutrition 0:05:10 Exercise 0:06:33 Supplements that can make you live longer 0:08:29 Sleep 0:10:22 Diagnostics 0:10:57 Relationships