Super Data Science: ML & AI Podcast with Jon Krohn

In Episode #1008, Jon Krohn digs into Anthropic's 35-page Founder's Playbook and pulls out the practical guidance for each of its four startup stages: Idea, MVP, Launch and Scale. AI has erased the three bottlenecks that historically gated company-building — capital, headcount and technical skill — turning the founder from individual contributor into an "orchestrator of agents." Along the way, Jon...

Benjamin Todd, co-founder and President of 80,000 Hours and author of the new Penguin Random House book 80,000 Hours: How to Have a Fulfilling Career That Does Good, joins Jon Krohn for a major update on career strategy in the AI era, his first appearance since before ChatGPT existed. Ben explains why “follow your passion” is backwards and why rare, valuable skills used to help others are what act...

In this month's episode of ICYMI, hear from Chip Huyen, Andrey Kurenkov, Frank Basso and Gilbert Eijkelenboom, discussing why moats are shifting toward physical systems and accumulated product intuition, how Astrocade built vibe coding before the term existed, what it's really like inside a deafeningly loud AI data center, why only 15% of people are technically self-aware and whether AGI requires...

Gilbert Eijkelenboom, bestselling author of People Skills for Analytical Thinkers and founder of the training firm MindSpeaking joins Jon Krohn to make the case that communication is a core data skill, not an optional extra. Gilbert shares the “And, But, Therefore” framework for turning dense analysis into a story stakeholders act on, the research suggesting only around 15% of people are genuinely...

Could an AI get good enough at AI research to build its own, more capable successor and kick off a compounding loop? That’s recursive self-improvement (RSI) and it surged into the conversation after Anthropic revealed that, as of May 2026, Claude wrote more than 80% of the code merged into its production codebase. In this Five-Minute Friday, Jon Krohn separates today’s AI-assisted coding from true...

Frank Basso, VP of Infrastructure at Lightning AI, joins Jon Krohn for a rare ground-level tour of the one layer of the AI stack the show had never covered in over a thousand episodes: the physical data center. Frank explains how Lightning AI provisions its 35,000-plus GPUs through hyperscale co-location, why everything new is liquid-to-chip cooled, how GPUs talk to each other over ultra-fast east...

Anthropic’s Claude Fable 5 was the most capable AI model ever released to the public and it lasted just three days before the US government forced it offline. Jon Krohn unpacks both halves of the story: what makes Fable 5 special, and why it was pulled. Fable 5 and its locked-down sibling Mythos 5 are the same model separated only by safeguards, in a new “Mythos-class” tier above Opus. Jon covers...

For this episode #1001 special, the tables are turned: SuperDataScience founder Kirill Eremenko takes the host’s chair and Jon Krohn is the guest. They trace Jon Krohn’s path from an Oxford neuroscience PhD to a New York hedge fund to founding the AI consulting firm Y Carrot, why he regrets leaving academia and how tools like Claude Code erased his hard-won technical moat and why that makes skille...

For this landmark 1,000th episode and the show’s 10-year anniversary, host Jon Krohn is joined by SuperDataScience founder Kirill Eremenko, who hosted the podcast for its first 400-plus episodes before handing over the reins. In a first for the show, the episode was recorded live with the audience invited to join on air, alongside surprise appearances from the team, longtime guests, and even Jon’s...

Chip Huyen joins host Jon Krohn for this milestone episode 999 to talk about her record-breaking book "AI Engineering" the most-read title on the O'Reilly platform last year and how the AI landscape has shifted since her last appearance. Chip breaks down what separates AI engineering from machine learning engineering, makes the case for a "start simple" workflow, gets candid about the real costs o...

In this month’s episode of ICYMI, Jon Krohn explores how AI agents are simultaneously creating new risks and unlocking powerful new ways of working with data. Hear from Anneka Gupta, Cal Al-Dhubaib, Trevor Manz, Jazmia Henry, Jeremy Mumford, and Jacob Miller, discussing why the old cybersecurity playbook breaks down in the age of Claude Mythos, how the notebook became an AI agent’s working memory,...

Dr. Andrey Kurenkov returns to the show to talk about Astrocade's astronomical growth from pre-alpha to over 20 million engaged users, what it actually takes to build a vibe-coding platform that scales, and how the broader AI landscape has shifted since his last appearance. Andrey shares behind-the-scenes lessons from building B2C user-generated content products, why the real moat is community rat...

TrueFoundry co-founder and CEO Nikunj Bajaj speaks to Jon Krohn about how enterprises like Nvidia and Siemens are realizing returns of over $100 million from single agent deployments, the AI gateway architecture that makes it possible to connect, observe, and govern agents at scale, and why the familiar advice to “start small” is the wrong way to roll out AI agents inside a large organization. Add...

Jazmia Henry joins Jon Krohn to break down what it actually takes to build end-to-end foundation models for the energy industry. From wrangling decades of handwritten oil-and-gas documents into usable training data, to bespoke tokenizers, reinforcement learning, and inference at scale, Jazmia walks through every stage of the stack. Along the way she explains why reinforcement learning models are "...

Unemployment for recent computer-science graduates now rivals rates for fine-arts and anthropology majors, and undergraduate CS enrollment fell 11% in 2025. In this Five-Minute Friday, Jon Krohn walks through the data on both sides of the debate, from Stanford research showing a 13% employment drop for young workers in AI-exposed jobs, to Federal Reserve studies finding no statistically detectable...

For years, AI content has come in the form of “use this library, use this tool” tutorials that age out within months. Jacob Miller and Jeremy Mumford, co-authors of the brand new Wiley book Architected Intelligence, wanted to write something different, a guide to the higher-level principles of building AI products and AI-first organizations that will still be relevant in five or ten years. In this...

While “tokenmaxxing”, the social media trend of maximizing AI token consumption as a vanity metric, takes off online, the physical infrastructure behind AI is slamming into serious bottlenecks. In this Five-Minute Friday, Jon Krohn maps out the four overlapping supply-chain constraints choking AI compute: GPUs (with NVIDIA Blackwell sold out through mid-2026), high-bandwidth memory (quintupled dem...

Dr. Trevor Manz of Marimo talks to Jon Krohn about Marimo Pair, an open-source agent skill that teaches coding agents like Claude Code how to drive a reactive Python notebook, reading cell state, running Python in the kernel, taking screenshots of cells, and iterating on data tasks the way agents iterate on traditional software. Trevor also unpacks recursive language models, his AnyWidget project...

Anthropic has built a frontier AI model so capable at finding software vulnerabilities that it has decided not to release it to the general public. In this Five-Minute Friday, Jon Krohn breaks down Claude Mythos Preview, a general-purpose model whose hacking abilities emerged as a side effect of broad improvements in code understanding and reasoning. Find out how Mythos achieved a nearly 100x impr...

Rubrik’s Anneka Gupta and Cal Al-Dhubaib speak to Jon Krohn about cybersecurity measures, the risks AI in business might pose for malicious attacks, and why AI should be kept “boring.” Find out how Rubrik safeguards client data, what zero trust is in the context of cybersecurity, and why cyber-resilience needs to be a top priority for companies looking to adopt AI. Additional materials: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠...

In this month’s episode of In Case You Missed It, Jon Krohn talks to guests about memory and education, and how artificial intelligence is continuing to help lower the barriers to access. Hear from Matt Glickman, Traci Walker-Griffith, Richmond Alake, and Linda Haviv, discussing the foundations of AI agent memory, how engineers can develop at scale, and why they believe AI could be your child’s pe...

Linda Haviv talks to Jon Krohn about staying current on AI matters, why open-source technology is narrowing the gap in its race with proprietary models, and how being a content creator in tech is key to career growth and longevity. She emphasizes that non-linear pathways to a career in tech can give applicants an edge, and stresses the importance of continuous upskilling to “stay relevant.” In her...

CTO of Propel Software Kishore Subramanian talks to Jon Krohn about how product lifecycle management (PLM) software and quality management systems (QMS) help ensure compliance, record management, and quality assurance. Listen to the episode to hear Kishore Subramanian talk about best practices for getting started with Agentforce 360, his top tips for deploying AI projects, and why yoga and meditat...

Oracle’s Director of AI Developer Experience Richmond Alake returns to the show to talk to Jon Krohn about agent memory; the network of systems, models, databases and LLMs that enable AI agents to learn and adapt over time. Listen to the episode to hear about Richmond’s “100 Days of Agent Memory” initiative, retrieval-augmented generation’s (RAG) limitations with AI agents, the layers of the AI ag...

Raju Malhotra, Chief Product and Technology Officer at Certinia, talks to Jon Krohn about the so-called SaaSpocalypse and how agentic AI is proving the doomsayers wrong. Listen to the episode to hear more about Certinia’s work with Salesforce and building with Agentforce 360, the three elements required for enterprise-grade agents, how AI agents have benefitted Certinia’s customers, and how to kee...