MDS PODCAST: Defining Parkinson's disease

Dr. Eduardo de Pablo-Fernández discusses with Dr. Samuel Kim recent advances in Huntington’s disease, including genetic mechanisms, emerging biomarkers, and the potential of huntingtin-lowering therapies and gene therapy.

Dr. Mitra Afshari discusses with Dr. Raul Martínez-Fernández recent advances in MRI-guided focused ultrasound for essential tremor and Parkinson’s disease, including improvements in safety and efficacy, its relationship with deep brain stimulation, and emerging neuromodulation approaches.

Ms. Nicole Duff discusses with Dr. Alison Yarnall the prevalence and impact of frailty in Parkinsonism, including how it is identified and measured and its implications for clinical trials and patient care.

Dr. Eduardo de Pablo-Fernández discusses with Prof. Tom Foltynie emerging disease-modifying and restorative treatments for Parkinson’s disease, including recent clinical trial findings and promising therapeutic approaches.

Prof. Wassilios Meissner discusses scientific advances in multiple system atrophy,  from our growing understanding of MSA pathophysiology to potential diagnostic biomarkers to investigational therapeutics.

Dr. Ignacio Mata discusses with Dr. Divyani Garg the dramatic increases in genetic testing globally over the last several years that have enhanced our understanding of the genetic architecture of Parkinson’s disease.

Dr. Sabine Hilfiker addresses with Dr. Tiago Outeiro the slight differences of alpha-synuclein pathology in LRRK PD and what they could mean in terms of cell biology and molecular mechanisms.

Dr. Jerome Honnorat sits down with host Dr. Divyani Garg at the 2026 MDS international Congress to review the most recent advancements in autoimmune movement disorders.

Dr. Cecilia Peralta sits down with host Dr. Michele Matarazzo to review the most recent findings and future of neuroimaging in the field.

Prof. Burn speaks with Dr. Michele Matarazzo about the initiaves and direction of MDS.

Dr. Genko Oyama gives us an inside look at the most exciting moments from the last full day of the MDS Congress — including 2 exciting Clinical Breakthrough announcements and his favorite case from the Video Challenge.

Dr. Andrew Siderowf shares what you missed from #mdscongress day three, which included a deep dive into the evolving AI landscape and insightful live patient rounds.

Dr. Thomas Kimber breaks down the eventful and science-packed first day of the #MDSCongress.

Highlights from day 2: Dr. Sanjay Pandey recaps the key takeaways, including from the aging & comorbidities and renown awardee lecture sessions.

Prof. Tiago Outeiro speaks with 2026 MDS Congress C. David Marsden Presidential Lecture Award winner Prof. Vincenzo Bonifati about his landmark genetic discoveries and the future of movement disorders research.

Sara Schaefer speaks with the MDS Congress 2026 Junior Award Winner Dr. Richard Morton about his prevalence study on Parkinson’s disease in Kalifi County, Kenya, a substudy of the Transforming Parkinson’s Care in Africa (TraPCAf) study.

In this episode, we speak with Zixiao Yin, recipient of a Junior Award at the MDS Congress, about his work on reconstructing deep brain activity from cortical signals. Using more than 700 hours of simultaneous cortical and subcortical recordings across different movement disorders, brain targets, and clinical states, Yin and colleagues developed deep learning approaches...

Dr. Sara Schaefer speaks with 2026 MDS Congress Stanley Fahn Award Lecture winner Dr. Beomseok Jeon about his career and the inspiration he drew from his time as a movement disorders fellow under Dr. Stanley Fahn.

Dr. Divyani Garg speaks with Dr. Hubert H. Fernandez about tavapadon, a once-daily selective dopamine D1/D5 receptor agonist, and what the TEMPO clinical development program tells us about its potential role in Parkinson’s disease (PD). They discuss the rationale for D1/D5 stimulation, findings from other TEMPO programs, the magnitude and clinical meaning of the motor...

Prof. Jeffrey Kordower and Prof. Franziska Richter Assêncio join Prof. Tiago Outeiro to discuss the historical use of animal models in the field of Parkinson’s disease. Together they review ethical issues, the value of different types of models, and their relevance to the field.

In this new episode of the Hot Topic ‘Prodromal synucleinopathies’ Dr. Eva Schäffer joins Dr. Eduardo de Pablo Fernández to discuss recent advances, future challenges, and practical clinical advice in prodromal Parkinson’s disease.

In this episode, Dr. Kathryn Yang discusses a case of a young girl with subacute-onset jerky movements with an interesting finding on oculomotor examination, and explores the etiological diagnosis of this peculiar syndrome. Read the article.

Sleep Specialist Dr. Laura Pérez-Carbonell joins Dr. Eduardo de Pablo Fernández to discuss a wide range of topics related to REM sleep behaviour disorder as a prodromal synucleinopathy.

In this episode, Dr. Mitra Afshari speaks with Dr. Jen Nagao about her latest work highlighting the automation of subthalamic deep brain stimulation (DBS) with Evoked Resonant Neural Activity (ERNA) in Parkinson’s disease. They discuss the potential benefits of ERNA over beta power in the operating room and future opportunities to explore this newer neurophysiological...

Dr. Todd Gross and Dr. Laxman Bahroo discuss with Dr. Sara Schaefer the real-world use of daxibotulinumtoxinA in patients with cervical dystonia following initial clinical trials and FDA approval. Read the article.