MDS Podcast

For this Hot Topics episode, Dr. Eduardo Fernandez sits down with Dr. Thomas Beach to discuss the advances and challenges ahead in tissue biomarkers for Parkinson's disease, including colon, salivary gland and skin biopsies.

Dr. Esther Cubo joins Dr. Sarah Lidstone and the MDS Podcast to discuss her recent work on the Spanish validation of the MDS Non-Motor Rating Scale. Together to go over the reasoning for this study, the extensive process of validating this scale and what benefits it will provide to Spanish speaking populations. Read the article MDS Non-motor Rating Scale

The Global Parkinson's Genetics Program (GP2) is a project designed to understand the architecture of Parkinson's disease (PD). Dr. Sarah Camargos sits down with Dr. Andrew Singleton to discuss GP2 and its initiative to increase our global understanding of PD and in doing so, better understand the genetic landscape of underrepresented populations.

Laryngeal dystonia (LD) is a rare disorder affecting the vocal cords. Dr. Sarah Camargos sits down with Prof. Kristina Simonyan while she breaks down the methodology and findings of her comprehensive study investigating the temporal-spatial signature of LD. Read the article

Dr. Poewe and Dr. Mahlknecht discuss the details of their Review Article of the Year on what we know about how DBS in Parkinson's disease alters symptoms, disability, survival, and more in this special episode. Read the article

Dr. Sara Schaefer speaks with Dr. Beatrice Heim, author of the MDCP Review Article of the Year 2023, about alpha-synuclein seed amplification assays of the CSF and their use in the diagnosis of synucleinopathies. Read the article

Dr. Eduardo Fernandez interviews Professor Günther Deuschl and Dr. Robin Wolke on their recent MDCP article on the challenges levodopa poses when predicting the outcome of subthalamic deep brain stimulation. Read the article

What new research is coming that may change the way clinicians treat tremor? Dr. Tiago Mestre shares his perspective on tremor treatment research with Dr. Hugo Morales.

Dr. Sara Schaefer sits down with Prof. Carolyn Sue and Dr. Shilpa Chitnis to discuss the newest offerings in MDS Education; the MDS Career Development and LEAP Programs.

What gene therapies are the most promising the field of movement disorders? Dr. Sarah Camargos met with Prof. Deniz Kirk at the 2023 MDS Congress to get his perspective on how the field of gene therapy has evolved over the years and where it has yet to go.

The role of alpha-synuclein in various proteinopathies is still unknown. Prof. Poul Henning Jensen discusses this hot topic with Prof. Tiago Outeiro.

Basic science research for movement disorder therapies is booming. Prof. Tiago Outeiro asks Dr. Lorraine Kalia what therapeutic targets she thinks are stealing the stage at this year's MDS Congress.

How can sleep predict cognitive decline in Parkinson's disease? Dr. Ron Postuma discusses his viewpoint and findings with Dr. Sarah Camargos at the MDS Congress.

MDS President Francisco Cardoso shares with Dr. Sara Schaefer his important takeaways from his presidential term and his hopes for the future.

What type of research is needed to help us better understand the phenomenology of stereotypic movements disroders? Dr. Hugo Morales asks Dr. Tammy Hedderly her viewpoint on the uniqueness of these disorders and what questions the field has yet to answer.

What direction will the field of PSP research go in the years to come? Prof. Gunter Höglinger sits down with Dr. Eduardo Fernandez at the MDS Congress to help answer that very question.

Multiple system atrophy (MSA) research has its challenges, nonetheless the field is still moving at a rapid pace. Dr. Eduardo Fernandez discusses the MDS Congress highlights for MSA with Dr. Alessandra Fanciulli.

Why is Parkinson's disease heterogeneity important to research. Dr. Connie Marras met with Dr. Eduardo Fernandez to discuss why understanding the heterogeneity of this disease may help with prevention.

What innovations in dystonia treatments do we have to look forward to? Dr. Mark Edwards sits down with Dr. Sarah Camargos to answer that vary question.

Dr. Sarah Camargos interviews Dr. Thiago Leal and Dr. Ignacio Mata about the need of genetic studies on underrepresented populations and the technical challenges they faced when alayzing admixture ancestries and X chromosome. Read the article

In this special issue celebrating the Movement Disorders journal Research Article of the Year 2023, Sara Schaefer discusses with Dr. Mario Zappia the effects of the short vs long duration responses to levodopa on cortical excitability and neuroplasticity in response to motor learning tasks in early Parkinson’s disease patients. Read the article »

In this special issue celebrating the Movement Disorders Clinical Practice journal Research Article of the Year 2023, Sara Schaefer discusses tic phenomenology in primary tic disorders vs. functional tic-like disorders with Dr. Tamara Pringsheim. Read the article »

Dr. Wszolek shares with Dr. Schaefer his extensive knowledge about the clinical, genetic, and pathological findings in Perry disease, a rare and likely underdiagnosed parkinsonian condition. Read the article.

In this episode, Dr. Pierre-Emmanuel Sugier discusses the epidemiological associations between PD and cancers. While investigating several European GWAS databases, his group raised the conundrum whether cancer and Parkinson's disease share common risk factors. Read the article.

In this episode, we interviewed Prof. Jian Feng about his most recent paper covering the role of parkin mutations in human A9 dopaminergic neurons and role they play in locomotor activities of early-onset PD. Journal CME is available until July 20, 2024 Read the article.