MDS Podcast

Dr. Shiro Horisawa discusses the latest clinical trial results on MR-guided focused ultrasound pallidothalamic tractotomy for cervical dystonia. He explores the technique's limitations, future prospects, and how it compares to existing therapeutic options. Read the article.

Dr. Hugo Morales Briceno interviews Prof. Ray Chaudhuri to discuss the real world-use of levodopa subcutaneous infusion in patients with Parkinson's disease.

Dr. Chan joins the podcast to discuss the results of their pilot study with Dr. Eduardo De Pablo-Fernández. The study uses a foot vibrotactile stimulation as an external cue for the treatment of freezing of gait in Parkinson's disease. Together they discuss how vibrotactile devices can be implemented in clinical practice. Read the article.

In this episode, Prof. Alexander Münchau talks about how machine learning video-based assessments can be leveraged to quantify tics in Tourette syndrome and how this technology has the potential to assist clinicians in tic detection. Read the article.

In this episode, Dr. Aasef Shaikh and Dr. Ming-Kai Pan give us a virtual guided tour of their labs, particularly discussing what they are presently working on. They further elaborate on how these studies can inform our understanding of tremor physiology and where they believe the field should be heading in order to finally understand tremor origin.

Dr. Michele Matarazzo interviews Dr. Victor Fung, President of the International Parkinson and Movement Disorder Society and lead author of the recent viewpoint published in the Movement Disorders journal. Together, they explore the biological definition and classification of Parkinson's disease, discussing its key insights, future prospects, and the implications of recent advances in the field. R...

In this episode Dr. Ludy Shih briefly describes the current approach to tremor, including pharmacological treatments, botulinum toxin injections and deep brain stimulation. She further dives into the exciting new developments of the past few years and new drugs coming down the pipeline.

In this episode, the two souls at the center of the new tremor classification join the MDS Podcast to discuss what essential tremor is. Listen as Prof. Kailash Bhatia and Prof. Günther Deuschl walk you through their clinical methods and future outlook on essential tremor. Do they agree? Disagree?

Growing evidence suggests a contributory role of tau protein in the pathogenesis of Huntington's disease. In this episode, Dr. Eduardo de Pablo-Fernández discusses the potential role of skin tau quantification as a biomarker for Huntington's disease with Dr. Jaime Kulisevsky and Dr. Iñigo Ruiz-Barrio. The authors discuss the results of the recent study correlating skin tau quantification with clin...

In this episode Dr. Alfonso Fasano interviews Dr. Petra Schwingenschuh on her approach to tremor in the clinic. She further explains the importance of a good history taking, how to clinically assess tremor of different body parts, and how to diagnose functional tremor.

Dr. Sara Schaefer interviews Dr. Jaclyn Martindale on stigma in the experiences of individuals with pediatric movement disorders and tic disorders. They discuss the reasons behind stigma, types of stigma, and ways that stigma is perpetuated and mitigated in this special episode for World Movement Disorders Day 2024.

Dr. Indu Subramanian shares her view on stigma affecting people with Parkinson's disease, along with some practical tips on how to fight it as doctors and as a society.

Dr. Natasha Fothergill-Misbah discusses stigma in movement disorders with Dr. Sara Schaefer, including the origins, types, and consequences of stigma, and how stigma may be perpetuated and combatted around the world.

Dr. Rick Helmich tells us about the role of functional MRI in understanding the circuits of tremor. The conversation starts with a description of his most famous theory on the pathophysiology of Parkinsonism tremor ('dimmer-switch' hypothesis) and moves towards other forms of tremors, such as dystonic, Holmes and essential and even physiological tremor.

Dr. Anna Latorre is interviewed by Dr. Sara Schaefer about her study exploring the role of transcutaneous spinal cord simulation for suppression of postural tremor in essential tremor, including the potential pathophysiological mechanisms and implications for therapeutic use. Journal CME is available until October 21, 2025 Read the article.

In the introductory episode for the Tremor Special Series, Dr. Elan Louis tells us about the epidemiology of tremor as well as patients' and health care providers' awareness (or lack thereof). He guides us through his journey from when his mentor suggested that he'd look into familial essential tremor to the most important discoveries of the last two decades. Finally he gives us a glimpse of what'...

Prof. Alessio Di Fonzo shares the results of his award winning, multi-center work examining genetic data from people with early-onset PD in hopes of highlighting the difficulties in interpreting genetic variants emerging from NGS-multigene panels. Read the article.

Dr. Hannah E. Reese and Mr. W. Alan Brown discuss their pilot study of a mindfulness-based group virtual intervention for tic disorders, that was co-developed with patients. Journal CME is available until August 21, 2025 Read the article.

Prof. Jeffrey Kordower shares the data in support of #PD being a copathology disease and what strategies may be in the future for protein aggregate clearance in age-related neurodegenerative diseases.

Alpha-synuclein based biomarkers have dominated the Parksinon's disease field over the past few years. Dr. Andrew Siderowf shares his views on the future of these biomarkers and what else the field may have in store.

Dr. Günter Höglinger discusses new genetic findings and other exciting research surrounding PSP and other atypical parkinsonisms.

Dr. Aasef Shaikh shares the exciting developments in the world of tremor and how he believes the use of technology will help answer some of the field’s big questions, including the personalization of treatment.

Dr. Victor Fung sat down with Dr. Michele Matarazzo at the #mdscongress to reflect on the advice from his predecessors and how that is helping him achieve his goals as MDS President.

Dr. Kishore Kumar shares the new genes associated with Parkinson's disease, dystonia, and ataxia. He also shares how new technologies, like long read sequencing, can assist in finding epigenetic changes.

Prof. Michael Zech takes a dive into his talk on gene discovery in dystonia. He explains how new findings can provide insight into the pathophysiology of dystonia and improve patient care and treatment.