Odds on Open

Can you start a hedge fund as a college student? Christina Qi, co-founder of Domeyard, did—and later built Databento, a modern market data API used by top algorithmic trading and quantitative trading teams. We get into how high-frequency trading (HFT) actually works, why clean order book/tick market data matters for robust trading strategies, and how a product-led model beats “talk-to-sales.” Chri...

Should you invest in the S&P 500, or look for smarter ways to beat the market? Jason Hsu, Co-Founder of Research Affiliates ($159B AUM) and now CIO of Rayliant, explains why simply buying the index or asking “should I invest in ETFs” isn’t enough. In this episode, he breaks down smart beta vs S&P 500, systematic investing, and how factor investing strategies and fundamental indexing can de...

Can you trade the stock market with AI? Yes: Renee Yao launched Neo Ivy Capital, a billion-dollar** AI hedge fund that uses AI in trading and investing to generate alpha. In this episode of Odds on Open, she explains how she built a quant hedge fund from scratch, scaling to over $1B AUM** with advanced AI hedge fund strategies that adapt to markets in real time and show how to trade stocks with ar...

In this episode of Odds on Open, Ethan Kho sits down with Joe Mezrich, Founder of Metafoura LLC and former Managing Director at Nomura Quant Strategies, to reflect on nearly 40 years in quant finance. Joe’s career spans the early days at Salomon Brothers—where he helped pioneer factor models, risk modeling, and even early machine learning in finance—through senior sell-side research roles at Morga...

Former Cargill Global Trading & Risk Management Director Kristine Engman Hochbaum explains how commodities trading strategies and quant trading strategies really work. On Odds on Open, she breaks down the sources of trading edge and alpha generation in today’s commodities markets, from agriculture trading to energy and metals. We cover why physical vs. financial commodities trade differently,...

This week, Ethan Kho sits down with Dr. Ernest P. Chan — former quant at Millennium and Morgan Stanley, and now founder of PredictNow.ai and QTS Capital Management. Ernie is one of the best-known voices in quant finance, author of Quantitative Trading, and a pioneer in systematic trading strategies. We cover:- When machine learning trading models work in markets — and when they fail- Why financial...

In this episode of Odds on Open, Ethan Kho sits down with Vinesh Jha, founder of Extract Alpha and former director of PDT Partners, to unpack lessons from the 2007 Quant Quake and how systematic investors can adapt in today’s crowded landscape. We cover:- What really happened inside PDT Partners when the firm lost $500M during the Quant Quake- Why so many quant hedge funds blew up in 2007 — and th...

What’s it really like working as a quant in fundamental research at Two Sigma—and how will AI, LLMs, and agentic workflows change quantitative trading strategies? Bill Mann, former Two Sigma fundamental researcher and founder of Harmonic Insights, joins Ethan Kho to break down how hedge funds build edge from widely available data and why “hacker” creativity still matters in systematic investing. B...

Can you analyze social media for investment decisions? How do hedge funds use Reddit posts, earnings calls, and SEC filings to find alpha? What’s the role of LLMs for financial analysis in 2025? Chris Kantos, Head of Quantitative Research at Alexandria Technology, joins us to explain how the buy side uses natural language processing (NLP), AI for investing, and text-based sentiment data to generat...

Financial markets are a game, says Grant Stenger. So how do you win in the financial markets? Grant, a former Jane Street intern and current crypto founder, believes markets are the most competitive game on earth—and he's been training to beat them since high school. From card counting in middle school to landing a hedge fund internship at QuantRes before university, Grant shares how a lifelong ob...

How do you become a solo quant trader and build your own systematic trading business? Robert Carver, ex-head of fixed income at Man AHL—a $63 billion systematic trading hedge fund—shares how he went from managing institutional capital to becoming an independent, full-time quant trader. He reveals the key skills, mindset, and tools needed to succeed in quant trading without working at a big firm, h...

What is edge in trading—and how do hedge funds and quant traders find edge in 2025? According to Agustin Lebron, former quant trader at Jane Street and author of The Laws of Trading, edge is what separates average traders from those who thrive at a top hedge fund. But today, finding edge requires more than just a good model—it demands judgment, adaptability, and a deep understanding of how quant t...

If venture capital underperforms the public markets, is it still worth the investment? For Avik Ashar, the answer is yes—but not for the reasons you think. Avik, a Principal at Riverwalk Holdings, an India-focused VC firm, argues that most people misunderstand how venture capital works and how to fairly evaluate VC fund performance. Venture capital, he explains, isn’t just about chasing unicorns o...

Is venture capital dead? Not for Guy Horowitz, who boasts 20+ years in the VC ecosystem, holding the title of partner at firms like DTCP, 33N, and ESH.vc. In this episode of Build to Last, we unpack the changing face of early-stage investing and startup funding—from the 2000s hardware boom to the rise of software unicorns, and now the new frontier: AI-first companies. Guy shares battle-tested insi...

How will AI affect education? Minh Tran has a lot to say about the future of learning in the age of large language models (LLMs) and generative AI. As the COO of GoodNotes—one of the world’s leading AI-powered note-taking apps—he’s at the forefront of how AI is changing the education system. For Minh, the future of learning is already here: “We need to rethink WHAT we teach, not just HOW we teach,...

Is a finance degree still worth it if you want to become a quant? In this week’s Build to Last episode, quant researcher and YouTuber Dmitri Bianco explains why he calls his own finance undergrad “a big mistake” — and why most quant roles today demand far more math, statistics, and programming than students realize. (The short answer to that first question is: no.)Dmitri shares how he went from a...

A second passport isn’t just for shady billionaires or globalist elites — it’s actually a legal, fast-growing strategy used by thousands of wealthy families to unlock global freedom. It’s also the core of a booming global industry that Krista Victorio, Partner at Orience, knows inside and out. On this episode of Build to Last, Krista explains how citizenship-by-investment works — and why families...

At no other point in history the #corporate and #academic worlds been so deeply at odds. The former sees the latter as useless bureaucrat over-thinkers, while the latter sees the former as money-driven opportunists placing profit over principle. But Dr. Davide Sola is rallying against this. His experience spans both the #boardroom and the #classroom. Early into his #career, he worked at #McKinsey...

The startup world is dog eat dog. “Move fast and break things,” so goes the Silicon Valley adage. For Illai Gescheit, this does not have to be the case: “You can still move fast and break things and be a kind person as well,” he says. The unconventional mantra is plastered on his LinkedIn headline. “Kindness is my strategy,” it reads. Indeed, it’s a practice that Illai must commit to in his day-to...

We live in a world of noise. Signals are in abundance. There is too much data, too much fuzz and fluff that makes decision-making a real challenge. It’s issues like these that founder Ryan Manuel is trying to solve. As the founder and CEO of Bilby, his main goal is to use AI and machine learning to automate regulatory and government analysis, turning fuzzy policy signals into real, actionable insi...

Every week, it seems that there’s always a new set of questions we’re pondering when it comes to AI: How will AI reshape the job market? How close are we to Artificial General Intelligence? Dr. Seth Dobrin, a General Partner at One Infinity Ventures and the founder of Silicon Sands, is here to give some clarity on these issues. What sets Seth apart in the world of AI investing is his commitment to...

Growing up, Dhira Vidhea loved to read and write. She’d devour John Green’s books as a teenager, and eventually wrote her own book titled “The Boy Who Broke In My Window” at age 13. “I always wanted to be an author,” she says. “That was my dream.” But publishing manuscript wasn’t as easy as she first anticipated: None of the literary agents she sent her book to wanted to work with her. From one ch...

One of Europe’s notable private equity success stories started in New York. Meet Keith Breslauer: native to Washington Heights, NYC and now the managing director of Patron Capital, a London-based private equity firm specializing in real estate and property that he founded in 1999. Patron represents leading U.S. and European institutions, endowments, pension funds and family offices, with approxima...

For founder and technologist Daniel Mika, the idea of building the future is as ordinary as the everyday. No surprise, then, that his first foray into the world of artificial intelligence started long before GPT and Grok were en vogue: In 2018, Daniel became co-founded GetDressed, an computer vision-powered fashion stylist, (at the time of launch, he was only 17). Daniel’s work in the startup worl...

While many bright minds have their sights set on Silicon Valley, founder Earl Valencia’s vision is set elsewhere: emerging markets, regions like Southeast Asia or Africa where the population is young, where standard national GDP growth is between 5-10%, and where there’s “ so much opportunity still to make change,” he says. Plentina, Earl’s last venture, did exactly that. He raised $5 million for...