Melanoma Matters

Summary In this conversation, James Larkin and Sapna Patel discuss the PRADO study, which focuses on neoadjuvant therapy for melanoma. The study explores the use of personalized response-driven approaches to treatment, based on the patient's response to combination immunotherapy. The study found that patients with a major pathological response had a low rate of recurrence in the first two years, s...

Summary In this conversation, James Larkin and Sapna Patel discuss neoadjuvant treatment in melanoma. They start by talking about the best films they've seen in the last five years, then move on to the background and rationale behind neoadjuvant therapy. They discuss the use of BRAF targeted therapy and its limitations, as well as the effectiveness of immunotherapy in the neoadjuvant setting. They...

Summary Birth order and bad second languages and Bolivia. In this episode of Melanoma Matters, hosts Sapna Patel and James Larkin discuss the Checkmate 915 trial, a significant study in the adjuvant treatment of melanoma. They explore the trial's design, the implications of IPI dosing, and the balance between efficacy and toxicity. The conversation emphasizes the importance of understanding negati...

Summary In this episode of Melanoma Matters, hosts Sapna Patel and James Larkin have a disastrous quickfire discussing their would-be porn star names and eventually move on to the Checkmate 76K study, which evaluates the efficacy of Nivolumab in adjuvant therapy for stage 2 melanoma. They delve into the interpretation of hazard ratios, the choice between Nivolumab and Pembrolizumab, and the manage...

Summary In this episode of Melanoma Matters, James Larkin and Sapna Patel discuss the Keynote 716 trial, focusing on the treatment of stage 2 melanoma. They explore the implications of adjuvant therapies, the significance of recurrence-free survival (RFS) and distant metastasis-free survival (DMFS), and the role of BRAF testing in managing stage 2 patients. The conversation highlights the challeng...

Summary James is injured! Hear about his favorite style of exercise (strength v cardio), and his no excuses attitude towards aches, pains, and niggles. In this episode, Sapna and James discuss the Keynote 054 study, which examines the efficacy of adjuvant pembrolizumab (Pembro) versus placebo in patients with resected stage 3A to 3C melanoma. They explore the study's design, results, and implicati...

Summary In this conversation, Sapna Patel and James Larkin discuss the Checkmate 238 landmark study on adjuvant therapy for melanoma. They touch on various topics, including food choices, pets, and the study design. They highlight the importance of considering the heterogeneity and tempo of melanoma in treatment decisions. They also discuss the challenges of conducting dedicated trials for mucosal...

In this conversation, James Larkin and Sapna Patel discuss the SWOG adjuvant study in melanoma. They cover topics such as the study design, the use of adjuvant anti-PD-1 therapy, the comparison with interferon and ipilimumab, and the potential side effects of adjuvant treatment. They also touch on the importance of risk-benefit discussions with patients and the need for biomarkers to predict toxic...

In this conversation, Sapna Patel and James Larkin discuss the EORTC 18071 study, which compared adjuvant ipilimumab to placebo in patients with stage III melanoma. They explore the use of adjuvant interferon in the past and the controversies surrounding its overall survival benefit. They also discuss the tolerability and side effects of ipilimumab, as well as the potential reasons for the surviva...

Summary In this conversation, James Larkin and Sapna Patel discuss the findings of the Checkmate 204 study, which looked at the treatment of brain metastases from melanoma using nivolumab and ipilimumab. They highlight that the combination therapy showed efficacy in asymptomatic patients with brain metastases, with a 55% intracranial clinical benefit rate. They also discuss the importance of early...

Summary In this episode of Melanoma Matters, James Larkin and Sapna Patel discuss the RELATIVITY 047 trial, which evaluated the combination of nivolumab and relatlimab in frontline metastatic melanoma. They cover the trial design, response rates, overall survival, toxicity, and the role of PD-L1 expression in treatment decisions. They also explore the potential use of nivolumab and relatlimab in p...

In this inaugural episode of Melanoma Matters, hear our what, why, and thank yous. Thank you (luv-u) to our producer big sister (general) Kippy , to David Gedge and The Wedding Present for use of their song "My Favourite Dress," and to the Uromigos duo of Tom & Brian for showing us what is possible. In Episode 01, Sapna Patel and James Larkin discuss the CheckMate 067 study, a randomized phase...