Web3 with Sam Kamani

Ran Hammer from Orbs joins Sam to break down how Layer 3 can give DeFi the same advanced execution tools as CeFi. He explains Orbs’ role powering advanced orders, liquidity aggregation, and intent-based perpetuals for major DEXs — plus his take on the biggest problems in DeFi today and where Orbs is going next. Key Timestamps [00:00:00] Intro & Ran’s journey from tech lawyer to Orbs’ business...

Riaz Mehta, founder of Ritestream, joins Sam to talk about disrupting Netflix with a decentralized, fan-funded streaming platform. He explains how Ritestream empowers creators, shares revenue with viewers, and uses NFTs and tokens to bring transparency to film financing — plus the role AI will play in reshaping media. Key Timestamps [00:00:00] Intro: Riaz Mehta shares how Ritestream is reinventing...

Laura from Gate Ventures joins Sam to share what founders need to succeed in today's crypto VC landscape. She discusses her investing journey, current thesis (stablecoins, RWAs, DeSci, and robotics), key founder traits, and how to pitch VCs the right way. Key Timestamps [00:00:00] Intro: Sam introduces Laura and her dual role at Gate Ventures and Gate.com. [00:03:00] Laura's Journey: From...

In this episode of Web3 with Sam Kamani , Bruno Maia, Head of Growth at Cartesi, shares his journey from telecom to Web3, his early ICO days, and how he joined Cartesi to help expand Ethereum’s design space with verifiable computation. Cartesi is building a Stage 2 optimistic rollup infrastructure with a fully verifiable Linux-based VM, enabling developers to write dApps in any language using fami...

Jan, founder of OpenMind , joins Sam to discuss how they're building a memory layer for AI agents in Web3. They cover the limitations of stateless agents, OpenMind’s modular memory architecture, and how developers can build “smart, sovereign agents” that persist across time, dApps, and chains. Jan also shares insights on use cases across DeFi, NFTs, and DAOs, and how OpenMind is designing for...

Simon Davis, founder of GOAT Gaming and Mighty Bear Games, joins Sam to unpack how they’re using Telegram, AI agents, and meme culture to scale Web3-native games. He breaks down their AI-powered assistant “Amy,” the technical challenges of building engaging agents, and how GOAT reached 6M+ users with Telegram-first distribution. They also discuss player retention, designing social-first games, and...

James Quinn Kumar from Binance ANZ joins Sam to explore how Binance reached over 280 million users in just 8 years. He shares the lessons from Facebook and TikTok that helped Binance thrive in B2C, the role of liquidity in institutional adoption, and how Gen Z sees Bitcoin as a new path to wealth in a world of rising property prices. They also dive into AI-generated content , digital ownership , t...

In this episode, Charlie, co-founder of Bitlayer , shares how they are building a Bitcoin rollup and trust-minimized BVM bridge to unlock BTC liquidity for DeFi while maintaining Bitcoin-level security. Backed by Franklin Templeton and top mining pools like F2Pool , Bitlayer is enabling yield-bearing BTC (YBTC), partnerships with Sui and Solana, and preparing for the launch of its BTR governance t...

What happens when an emerging‑markets banker, lifelong Reddit degen, and early Ethereum believer builds a global crypto fund focused on AI? Meet Matthew “Matty” Graham , Managing Partner at Ryze Labs . Matty shares how a pizza post pulled him into Bitcoin, why the Ethereum whitepaper was his “drop everything” moment, and how Ryze helps founders reach 2B+ users across emerging markets through its “...

In this episode, COTI Network CEO Shahaf Bar-Geffen joins Sam to unpack why privacy + scalability are the two missing pillars holding crypto back from mass, institutional adoption. Shahaf recounts COTI’s journey from 2017 payment rails to today’s garbled-circuit EVM , explains “privacy on demand” for any chain, and reveals how AI trading agents and a perp DEX called ProX are already running on the...

Evan Kuhn, President of DeLorean Labs, joins Sam to share how the iconic car brand is entering Web3. From on-chain car reservations and data-powered utility to the launch of the DMC token and partnerships with stars like Patrick Stewart and Christopher Lloyd — DeLorean is building much more than nostalgia. They discuss how the Flux Protocol enables drive-to-earn rewards, the role of the Sui blockc...

Alex from NodeOps joins Sam to share how they’re building a decentralized infrastructure platform that’s already generating millions in revenue. She discusses her background at Google and other Web3 infra giants, NodeOps’ unique AI-powered tools, dynamic mint-and-burn tokenomics, and how they’re shaping the future of DePIN. From staking to Security Hub to developer traction, Alex breaks down what...

Usman Wahid, a 23-year veteran lawyer and now founder of Legalise, joins Sam Kamani to explore the evolution of AI in the legal world. They dive into hallucinations in legal AI, how Legalise enables smarter contract negotiation for SaaS companies, the tension between centralized vs decentralized AI models, and how the legal profession must adapt. Usman also shares the importance of human-in-the-lo...

Vadym Rozov, founder of Simplify Labs, joins the podcast to break down the regulatory future of crypto in Europe. With MiCA and DORA reshaping the landscape, Simplify Labs is helping exchanges stay compliant and launch fast with modular white-label solutions. Vadym shares what sets their platform apart, the challenges of MiCA implementation, how banks are evolving into exchanges, and what startups...

Michael from 0G.AI joins Sam to discuss how they're building the AI operating system of the decentralized world. From decentralized compute and high-throughput storage to local consensus clusters and alignment networks, 0G is tackling the hardest infrastructure challenges at the intersection of AI and blockchain. With over 10 million wallets, 500+ companies building on Testnet, and $350M raise...

What if your wallet could pay gas fees on any chain—using just BNB? In this episode, Sam Kamani speaks with founder Rishi, Yashi and Divyansh from Tychi Wallet about building a next-gen smart wallet with AI, on-chain privacy, and a universal gas framework (UGF) that simplifies multi-chain interactions. They discuss how Tychi aims to replace clunky user experiences with smart abstraction, social re...

Robert Mofrad from Serenity joins the show to talk about digital asset inheritance, decentralized data survivability, and the power of biometrics in Web3. From seed phrase backups to biometric cards that double as wallets, Serenity is tackling the often-overlooked infrastructure needed for long-term Web3 adoption. Robert also shares his thoughts on RWA vs. RWS (Real World Services), regulatory gap...

What if your entry point to crypto wasn’t Bitcoin or ETH… but a Real World Asset backed token tied to real oil production? In this episode, Dave from OilXCoin shares how their team is bridging the gap between traditional energy markets and Web3 by launching a token which has received regulatory approval. From upstream oil leases and production logistics to regulatory compliance, licensed secondary...

What’s holding back enterprise adoption of blockchain? In this episode, Sergio from Sonar X joins Sam to explain why the missing piece is data infrastructure . Drawing from experience at Bloomberg and AWS (where he led Amazon Managed Blockchain), Sergio breaks down why most blockchain systems are broken at the data layer—and how Sonar X is building a scalable, multi-chain backend to fix it. From a...

What if smart contracts could see and react to events across multiple blockchains—automatically? In this episode, I speak with Rong Kai , co-founder of Reactive Network , a groundbreaking Layer 0.5 protocol designed to enable reactive smart contracts that operate fully on-chain. If you're a developer, founder, or anyone interested in the future of composable, automated smart contracts, this ep...

Sim Khela from Farmsent joins Sam to explore how blockchain, sensors, and co-ops are creating a new agricultural economy. From decentralized food marketplaces to tokenized trade finance and carbon credits, Sim breaks down how Web3 can uplift farmers, ensure food security, and transform supply chains globally. With 160,000 farmers onboarded, partnerships across continents, and a “children-first” KP...

What does it take to bring regulated, yield-bearing assets like U.S. Treasuries on-chain? Michele Crivelli, co-founder of NexBridge, shares how they're solving financial inclusion through tokenization of RWAs on the Liquid Network. From regulatory approvals in El Salvador to plans for tokenized equities and discretionary mandates, Michele breaks down the steps, the setbacks, and the massive po...

Jon Kol, founder of Hyperlane, joins Sam Kamani to dive deep into one of crypto’s biggest challenges—interoperability. From his days at Morgan Stanley to building Hyperlane, Jon shares how they’re enabling any chain to communicate with any other through permissionless, modular frameworks. He explains why monolithic architectures can’t scale, how modular security flips the bridge security model, an...

Martins from Gravity Team joins Sam to discuss the evolution of market making in Web3. Starting as a prop trading desk in 2017, Gravity now trades 1% of all spot crypto volume, provides liquidity to token projects, and invests in Web3 infrastructure. Martins explains what founders should look for in a market maker, why stablecoins and payments are the next wave, and how Gravity is building a globa...

Lucian from MultiversX (formerly Elrond) joins Sam Kamani to break down how they’re building one of the fastest L1 blockchains in the world. From sharding to Supernova, discover how MultiversX is tackling decentralization, scalability, and real-world adoption with a new wave of architecture, global partnerships, and government use cases. Lucian also shares what he’d do differently, how they're...