UnNatural Selection

Can Brainwaves Become Biomarkers? In this special episode of unNatural Selection , produced in partnership with Mass General Brigham ahead of the World Medical Innovation Forum , we explore how AI is transforming EEG from a blunt clinical tool into a precision instrument for neuroscience. We dive into how companies like Beacon Biosignals are decoding brainwaves at scale—advancing drug development,...

Grand Slam Architect: Rick Macci on the Champion’s Mindset What do world champions have in common—and how do you spot them before the world does? In this episode of UnNatural Selection, legendary tennis coach Rick Macci joins us to break down the art and science of identifying raw talent and shaping it into Grand Slam greatness. Coach to Serena and Venus Williams, Jennifer Capriati, and Andy Roddi...

A Genome Unraveled: The Code of American Innovation In this episode of UnNatural Selection , we sit down with Dr. Eric Green, former Director of the National Human Genome Research Institute (NHGRI) and a pioneering force in genomics innovation. Dr. Green reflects on his experience helping to lead the Human Genome Project, discussing how competition between research labs and private companies shape...

Designing Delight: Serving Experiences, Not Just Meals In this episode, we sit down with Eric Papachristos, the restaurateur behind some of Boston’s most iconic dining destinations, including La Padrona, Trade, Porto, Saloniki Greek, and The Venetian. Known for blending elevated design with thoughtful hospitality, Eric shares how he builds restaurants that feel both personal and unforgettable. We...

From Concept to Clinic: How MGB Shapes and Adopts Innovation Join us as we explore healthcare innovation with Chris Coburn, Chief Innovation Officer at MassGeneral Brigham, one of the largest and most influential healthcare systems in the US. Based in Boston—a global hub for biomedical innovation—MGB is not just an adopter of new technologies but a co-investor and co-designer, actively shaping sol...

Game On: Innovating the Future of Gaming In this episode of UnNatural Selection , we sit down with Yohan Sengamalay, a leader behind the development of legendary gaming platforms like Xbox and PlayStation . Yohan shares his journey through the evolution of the gaming industry, offering an insider’s perspective on how competition and innovation drive success in entertainment. We’ll explore the stra...

Innovating at the Edge of the Unknown What does it take to lead innovation when the risks are deadly and the stakes are cosmic? In this episode, I speak with Dr. Ed Hoffman, NASA’s first Chief Knowledge Officer, about how one of the world’s most visionary organizations manages knowledge, leadership, and learning when even the smallest misstep can be catastrophic. We explore how NASA pushes the bou...

The Business of Survival: Lessons from the Front Lines of Self-Defense In the rawest form of survival of the fittest , there’s no margin for error—only adapt or be overcome. In this episode, we sit down with Dennis Amato, a world-renowned Krav Maga expert and elite MMA trainer who has spent over 20 years preparing special forces, law enforcement, and civilians for life-or-death situations. From th...

The Big Picture That Kodak Missed In this episode of UnNatural Selection , we hear from Steven Sasson, the inventor of the first handheld digital camera—created at Kodak in 1975. At the time, Kodak was a powerhouse in photography, with over 100,000 employees and a dominant global brand. But rather than embrace Sasson’s invention, Kodak saw it as a threat to its lucrative film and paper business. C...