This Week in Virology

TWiV reviews a new H1N1 swine influenza virus from China with pandemic potential, Ad5 vectored SARS-CoV-2 oral vaccine candidate, Operation Warp Speed vaccine candidates, FDA guidance on vaccine approval, and answer listener email. Hosts:  Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Link...

From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA. Host:  Vincent Racaniello Guests: Sheemei Lok , Dahai Luo , Eng Eong Ooi , and Ashley St. John Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Dengue virus and endothelial...

Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 infections in non-humans, vesicular stomatitis in Kansas horses, and answer listener questions. Hosts:  Vincent Racaniello, Dickson Despommier , Alan Dove , Kathy Spindler and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV!...

Vincent, Rich, and Brianne discuss a study estimating the fraction of symptoms and severe disease after SARS- CoV-2 infection, cellular immune responses without seroconversion during interfamilial infections, and answer listener email. Hosts:  Vincent Racaniello, Rich Condit , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this...

From the Environmental Health Institute in Singapore, Vincent speaks with Director Lee Ching Ng about their work to control viral infectious diseases, including the controlled release of mosquitoes containing Wolbachia endosymbionts to inhibit viral transmission. Host:  Vincent Racaniello Guest: Lee Ching Ng Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV!

Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymptomatic SARS-CoV-2 infections, age-dependent effects on transmission, and answer listener email. Hosts:  Vincent Racaniello, Dickson Despommier , and Alan Dove Guests: Daniel Griffin and Chuck Knirsch Sub...

Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the laboratory, and tackle listener email. Hosts:  Vincent Racaniello and Rich Condit Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Austin TX key i...

Vincent visits the National Centre for Infectious Diseases and speaks with Executive Director Leo Yee-Sin and Consultant Nancy Tee about the main hub for both clinical treatment of infectious diseases and outbreak management in Singapore. Host:  Vincent Racaniello Guests: Leo Yee-Sin and Nancy Tee Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for thi...

Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice. Hosts:  Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin , Chuck Knirsch, and Ralph Baric Subscribe (free):  iTunes...

Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field. Hosts:  Vincent Racaniello and Rich Condit Guest: Frederick A. Murphy Subscribe (free):  iTunes ,  Google P...

Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19. Hosts:  Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Guests: Daniel Griffin , Chuck Knirsch, and Sabra Klein Click arrow to play Download  TWiV 624 (91 MB .mp3, 152 min...

Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work. Hosts:  Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Peter Daszak Subscribe (free):  iTunes ,  Google Podcasts...

Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate. Hosts:  Vincent Racaniello , Rich Condit , and Brianne Barker Guest: Emmie de Wit Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Respiratory disease in macaques inocula...

Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email. Hosts:  Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Guest...

Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19. Hosts:  Vincent Racaniello , Rich Condit , and Brianne Barker Guest: Jon Yewdell Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode T cell targets in COVID-19 patients (Cell) SARS-CoV-2 seroconversion in huma...

Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2. Hosts:  Vincent Racaniello , Rich Condit , and Brianne Barker Guest: Raul Rabadan Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Rabadan Laboratory Understanding Coronavirus (Amazon) Topolog...

From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine. Hosts:  Vincent Racaniello Guests: John Mackenzie , Jon Epstein , Eun-Chung Park , and Linfa Wang Subscribe (free):  iTunes ,  Google Podcasts...

Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email. Hosts:  Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free):  iTunes ,  Google P...

Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions. Hosts:  Vincent Racaniello , Rich Condit , and Kathy Spindler Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Drowning in COVID-19 papers (Science) CORD-19 201...

Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease. Hosts:  Vincent Racaniello Guests: Peter Daszak Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Intro music is by  Ronald Jenkees . 20% off The Invisible ABCs for TWiV listeners!...

Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions. Hosts:  Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscrib...

Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions. Hosts:  Vincent Racaniello, Rich Condit , and Kathy Spindler Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode COVID-19 brings out dark side of science ( Mother Jones , Wired ) Jenner In...

From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases. Hosts:  Vincent Racaniello Guests: Richard Hatchett and Linfa Wang Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Intro music is by  Ron...

Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions. Hosts:  Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Michael Schmidt Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a ...

The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions. Hosts:  Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode FDA revises statement on antibody tests (FDA) Serology...