This Podcast Will Kill You

We are coming at you with our very first live episode from Perth, Australia! Here at the 2024  Australian Institute of Occupational Hygienists   Annual Scientific Conference and Exhibition , occupational hazards and exposures get top billing. And one of the most ubiquitous hazards, experienced by nearly every industry is fatigue, specifically fatigue caused by circadian rhythm disruption. In this...

Everyone’s got a favorite disease movie. What’s yours? Does it feature zombies like 28 Days Later (2002), or is it more grounded in reality, like Contagion (2011)? Does it end with a glimmer of hope or with a dose of despair? Who are the bad guys and who are the good guys? From the early days of disease movies like Panic in the Streets (1950) to more recent films like Little Joe (2019)...

Yes, the world may be out to get us with allergens around every corner, but we’ve got some tricks up our sleeve to help us cope. Our allergy treatment toolkit includes an impressive suite of tools, and in the second episode of our two-part series on allergies, we focus on three in particular: antihistamine medications, allergy shots, and the epinephrine auto-injector (aka the EpiPen). We tak...

Sometimes it seems like the world is out to get us: bees in our garden, pollen in the air, nuts in our brownies, any number of other things that could trigger an allergic reaction ranging from itchy eyes and a runny nose all the way to anaphylaxis. Why must our bodies react in such over-the-top ways to these seemingly innocuous substances? In the first episode of our two-parter on allergies, we ex...

In February 2012, Paul Volkman was sentenced to four consecutive terms of life imprisonment for his role in illegally prescribing and dispensing pain medications that resulted in the deaths of several individuals in his care. This was a remarkable case, both in terms of the lengthy sentence as well as the perpetrator. Paul Volkman was a highly-educated physician researcher, who earned both his MD...

For decades, it seemed like the appendix would go the way of 8-track players, pagers, and the phonograph. Outdated, obsolete, not worth keeping around. Surgeons performed appendectomies like it was spring cleaning - when in doubt, cut it out. But then the tides began to turn as medicine started to question the long-held belief that the appendix is a defunct organ (on a good day) or a ticking time...

Among the many conditions that creep under your skin and make scratching irresistible, scabies alone holds the honor of being called simply “The Itch” for centuries. In this episode, we examine how the burrowing scabies mites cause this extremely uncomfortable sensation, what we can do to halt their progress, and how contagious they really are (less than you probably think). Today, the...

A mere 150 years ago, uttering the words “scarlet fever” was enough to strike fear into the hearts of many, especially parents of young children. For a brief period of time, this disease, caused by an infection with the bacterium  Streptococcus pyogenes , reigned as a leading cause of childhood death in many parts of the world. It left its mark on gravestones, in public health dec...

We really don’t give fungi the credit they deserve. Over the years of this podcast, we’ve covered only a handful of fungal pathogens, and pathogenic fungi themselves represent a teeny tiny proportion of the incredible diversity of fungal life on this planet. But with this book club episode, we’re attempting to correct this oversight, at least a little bit. Toxicologist and scienc...

That same little bottle of retinol serum sitting on your bathroom counter - how does it work? Does it actually work? Those are the questions we’re taking on in part two of our retinoids two-parter. The answers, as you might expect, are complicated. Because as it turns out, “retinoid” is a catch-all term for a bunch of different types of compounds, all of which work in slightly di...

That little bottle of retinol serum sitting on your bathroom counter - what do you know about its history? This week, we’re digging deep into the man behind the medicine, renowned dermatologist Dr. Albert Kligman, and the unethical research he conducted at Holmesburg Prison in the mid-20th century. Kligman’s research program at Holmesburg spanned decades, involved dozens of experiments...

When the Massachusetts Institute of Technology admitted in 1999 that they had discriminated against women on its faculty, it sent shockwaves throughout institutions of higher learning across the country. In this TPWKY book club episode, Pulitzer Prize-winning journalist  Kate Zernike  joins us to discuss her book  The Exceptions: Nancy Hopkins, MIT, and the Fight for Women in Scienc...

Stiff person syndrome, like many rare diseases, does not get nearly the same amount of screen time or name recognition that other, more common diseases do. For many people, Celine Dion’s announcement of her diagnosis with the condition in 2022 marked the first time they had heard of it. This limited awareness surrounding stiff person syndrome marks just one of the many challenges keeping thi...

Five years ago, we asked you all to ask us anything, and you delivered. We answered dozens of listener questions, like how we first met, our favorite quarantinis, where we were in our career journeys, and so many more. But in the years since that first “ask us anything”, a lot has changed for both of us! So we’re coming back to you with the answers to more of your probing questio...

How is it that we can’t remember where we put our keys or the name of the person we just met, but we can recall in excruciating detail the embarrassing interaction we had at the grocery store ten years ago? Sometimes it seems like our memory works against us more than it does for us. But, as it turns out, this aspect of our memory is more a feature than a bug, and the key to understanding the diff...

One day, you’re enjoying a beautiful hike through the tall grass. A few months later, you find yourself in anaphylaxis from a post-hike hamburger. The culprit: a tick bite. In this much-requested episode, we take on alpha-gal syndrome, the red meat allergy triggered by the bite of a tick. Sometimes science is stranger than fiction. How exactly does an encounter with a tiny arachnid cause your thro...

For life on this planet, iron is not optional. It is essential. When our iron levels are low, we can get sick, and when they get really really low, we can even die. But you know what they say, too much of a good thing can be a bad thing. In the case of iron, the genetic condition hemochromatosis is often to blame for iron overload, but why is too much iron a bad thing? In this episode, we explore...

Phosphorus is an element that wears many faces. Its overuse as a fertilizer has polluted freshwater ecosystems, transforming rivers and lakes from thriving communities to lethal zones devoid of life. Its role as an explosive has brought fiery death and suffering to many during times of war. And its dwindling global supply poses an existential threat to humanity. Because phosphorus is not just a de...

The stethoscope. It’s iconic. You’re playing Pictionary and you pull the “doctor” card? Easy - sketch a stethoscope. Need a last-minute Halloween costume? Easy - throw a stethoscope around your shoulders. Google image search “doctor” and you can count the number of stethoscope-less doctors on one hand. How did this instrument become so emblematic of the field of medicine? What can it tell us about...

“Is it gonna be poop or is it gonna be barf?” It’s the question we all fear during a bout of food poisoning when time is of the essence and a decision has to be made before it’s made for us. Often, the germ forcing this question upon us is none other than the dreaded norovirus. First called “winter vomiting disease” for reasons obvious to anyone who has been unfortunate enough to become infected,...

In the pre-antibiotic era, tuberculosis was one of the biggest killers humanity ever faced. The specter of the ‘great white plague’ hung over towns and cities across the world, cities like New York whose population boom in the early 20th century paved the way for this deadly disease to spread throughout crowded tenements. As tuberculosis rates in NYC reached a breaking point, city officials sought...

In last week’s episode/love song to poison control centers, we journeyed through the history of these centers, from idea to institution. This week, we pick up where we left off by taking stock of the incredible impact that poison control centers have had on public health and individual lives. We also get a thrilling behind-the-scenes look at the operational side of things - who is on the other end...

If you’ve ever called poison control, you probably already have a deep appreciation for the voice on the other end of the line who provides solid answers, emanates calm, and empowers you to take whatever steps necessary to be safe and healthy. If you haven’t, this episode will turn you into a superfan anyway. How did this incredibly valuable yet often overlooked service come to be, and why did it...

Roads are essential to our modern lives, so much so that they largely exist in the background of our minds. When we do think of roads, we’re either complaining about traffic or celebrating them for enabling our restless need to explore. Can you imagine if all of the world’s 40 million miles of roads were suddenly erased? Chaos for humanity. But a boon perhaps to natural ecosystems. In  Crossings:...

Think of an infectious disease. What comes to mind? A viral infection like influenza? Or a bacterial illness like cholera? Maybe some of you thought of a fungal pathogen or a parasite. But how many of you thought of a cancer? In this episode, we explore the bizarre, stranger than fiction story of devil facial tumor disease (DFTD), a transmissible cancer that has devastated Tasmanian devil populati...