This Podcast Will Kill You

The widespread use of leaded gasoline in the 20th century led to one of the world’s biggest public health and environmental disasters, the effects of which are still present today. Since its development in the 1920s, leaded gasoline has been linked to premature death, cognitive impairment, and behavioral issues in millions around the globe. How was such a toxic substance permitted to be sold...

Ah, the new year. After the last month and a half of indulgent food and drink, disrupted schedules, and laying around the house, who doesn’t feel like they’re in need of a whole-body cleanse? There are plenty of companies who are more than happy to provide that product or service that promises to flush away toxins from your skin, gut, blood, brain, you name it. But what exactly are the...

This episode originally aired on January 11th, 2022. Chances are you know someone with endometriosis, or perhaps you’re affected yourself. But despite its incredibly high prevalence, endo remains almost criminally understudied, undertreated, and underacknowledged. In this episode, we aim to shed light on many aspects of endometriosis, first by examining the “what” and “how&...

This episode originally aired on January 25th, 2022. In light of the recent changes by RFK jr’s Advisory Committee on Immunization Practices (ACIP) to eliminate the universal birth dose of the hepatitis B vaccine in the US, a decision which will result in preventable infections and deaths in this country every year, it seems timely to remind everyone of the global consequences of this incred...

Did your grandma ever warn you against going out in the cold with wet hair because “you’ll catch your death”? Or have you ever tossed a few more carrots into your shopping basket in the hope that they’ll improve your vision? There are countless health myths about how to prevent or treat disease, what food will give you superhuman powers or turn your kid into a whirlwind of...

[Content warning: self-harm, suicide, violence] In this day and age, we are equipped with an abundance of tools and knowledge to fight the spread of disease. Yet what good does that toolkit do if we lack the resources or the will to implement it where it is needed? One area of great need is our correctional facilities, our prisons, jails, immigration detention centers, and juvenile detention cente...

We ended last week’s episode on a bit of a cliffhanger: is salt actually bad for us and if so, why does there still seem to be a debate? This week’s episode holds all the answers. We’re sifting through the noise to figure out what salt actually does in our bodies, how it might impact our health, and why we crave this delicious substance. If you’ve ever wondered how we&rsquo...

Have you ever thrown a pinch of spilled salt over your left shoulder? Or said to someone “well, take his opinion with a grain of salt”? Or looked up the potential salary of a job listing? Salt is so deeply embedded in our cultures, our languages, our history as a species that we often take its influence for granted. We may forget (or perhaps we never knew) how much history is held with...

In an anatomy and physiology class, you may learn how the different heart valves work to circulate your blood, how the structure of your kidney helps to maintain electrolyte levels, and how the expansion and contraction of your lungs sets off a carefully orchestrated cascade of gas exchange and transport. The human body is an endlessly fascinating machine. But when you spend so much time learning...

If you were asked to describe necrotizing fasciitis in three words, you might choose: rapid, deadly, and rare. The third of those adjectives may provide some comfort, but the first two are the clear inspiration for this infection’s more lurid nickname: flesh-eating bacteria. In this episode, we get up close and personal with necrotizing fasciitis and its causative agents. We start off by exa...

It’s the stuff nightmares are made of. A fly lands on an open wound and lays hundreds of eggs, from which hatch countless ravenous maggots. There they writhe, devouring flesh, insatiable and relentless. Every minute they dig deeper and deeper until flesh gives way to bone. Even the species name of these maggots inspires a shiver of fear: Cochliomyia hominivorax - “man eater”. Thi...

Science doesn’t always get it right the first time (or the second, or the third, or even the ninety-ninth!). And while we may chuckle at the outlandish things people believed or the goofy experiments they tried, we forget two things: 1) those failures helped us get where we are today and 2) a hundred years from now, people will probably be laughing at the “cutting edge” medical k...

As we learned last week, starvation extends far beyond hunger and what a lack of food does to the human body. Similarly, famine is much more than a food shortage and starvation on a population-level scale. This week, we’re picking up where we left off last episode to explore the definitions, drivers, and many dimensions of famine. We trace famines throughout human history, asking how they ha...

Deprived of food, our bodies do the best they can to keep us alive and functioning as long as possible. As the days pass, the rhythms of our lives change: our metabolism, our heartbeats, our hormones, even our thoughts shift to adjust to this period of scarcity. This response is evolutionarily engrained, following a variable but fairly prescribed path. In this episode, we trace that path, explorin...

The United States is in the midst of a monumental mental health crisis, with one in four people predicted to experience mental illness at some point in their lives. Adequate mental health care remains out of reach of so many due to a myriad of factors: unaffordability, stigma, shame, and racism, to name a few, leaving enormous gaps in mental health equity. The roots of these inequities can be trac...

Every year, millions of babies around the world are screened for dozens of treatable conditions within the first day or two of life. What it takes is a few drops of blood on some filter paper, and what it gives is profound: potentially life-saving information. The advent of newborn screening is one of the greatest public achievements of the 20th century; since their earliest implementation, screen...

None of us are ever truly alone. Our bodies are home to untold numbers of microbes, chilling on our skin, in our guts, throughout our respiratory tract, inside our bellybuttons, under our fingernails, and beyond. For the most part, we live in harmony with these critters, never giving them a second thought. But occasionally, they may grow a bit too friendly, taking advantage of our hospitality to g...

When your car breaks down or your fridge goes on the fritz, you can order a replacement part and get things back up and running in no time. The same cannot always be said for another intricate machine: the human body. For centuries, scientists have grappled with making or transplanting suitable replacements for nearly every body part, from hearts to hair and from legs to lungs. We’ve come qu...

Last week, we took you through all the ways that cold can harm us and the harrowing history of humans perishing at its icy hands. Ending the story there would be skipping over the parts where cold gets to play the hero, rather than the villain. In the second installment of this frosty miniseries, we explore the situations in which we might use cold to protect us and how it actually works. We also...

For all our wondrous adaptations as a species - our big brains, our capacity for language, our opposable thumbs - we humans are not well-equipped to deal with the cold. Take us out of our insulated dwellings, take away our winter clothes, and things can get dicey fast. From frostbite to hypothermia, the cold can settle into our bones, leading us down a path where injury or death are possible outco...

The development of antibiotics was one of the greatest turning points in the history of medicine. Bacterial infections that were once death sentences were cured within a matter of days after administration of these lifesaving compounds. But the honeymoon didn’t last long, as resistant bacterial strains emerged and spread. Now, antimicrobial resistance poses one of the greatest threats to glo...

Some things just go together: peanut butter and jelly, bacon and eggs, milk and cereal, London and smog. Or at least, that’s the way things used to be until the Great Smog of 1952. (Don’t worry, the first three pairings are safe). If you’ve watched The Crown, you may remember an early episode in which a thick, noxious smog surrounded the entire city of London for days on end. Peo...

For most of us, there probably hasn’t been a good reason for you to think about your gallbladder. Ever. Much of the time, it sits there, silently storing, concentrating, and, when needed, churning out bile every day. But occasionally, this unassuming organ will announce itself through waves of unceasing, excruciating pain brought on by a blockage of some sort. Why it does this to us, what we...

In the first years of the COVID pandemic, a debate raged: was the virus transmitted via respiratory droplets, or was it airborne? For some, this distinction seemed overly technical, pedantic even. But for others, it represented decades of dismissal and missed opportunities - opportunities that had cost untold lives. In this week’s TPWKY book club episode, renowned science writer and journali...

Last week, we took you on a journey of discovery and innovation, and this week we’re gonna tell you how the heck it all works. That means a deep dive into the nitty gritty of SSRIs, from what serotonin does (A LOT, as it turns out), to why blocking its uptake has the effects it does, from the different side effects of SSRIs, to how effective they really are. The discourse surrounding this cl...