This Is Only A Test

“Ötzi the Iceman was a jolly happy soul…”  Today, Mickey Urdea is discussing Ötzi the Iceman, the natural mummy discovered by accident in 1991 frozen atop the Ötztal Alps between Austria and Italy (which is, of course, how he got his nickname). Besides being the oldest natural mummy of the Copper Age, Ötzi’s story is a tale of international intrigue, unearthed ancient diseases and their possible c...

On this episode, Mickey Urdea is going with the flow - the lateral flow! The most commonly known type of lateral flow assay is the pregnancy test, but now with self-tests for Covid-19, LFAs are more popular than ever! Mickey gives you the rundown on the development of LFAs and their components, the different common targets for lateral flow tests, and where the technology is today and where it is g...

On this week’s episode, Dr. Mickey Urdea is reviewing palynology, the study of grain, pollen, and other spores, and its use in forensics! Dr. Urdea covers how palynology has been used (or underused) in the 20th century, and discusses two specific criminal cases in which convictions have been determined with palynological evidence. And he's not pollen your leg!

This week, Dr. Mickey Urdea is weighing in on the reality TV show, "The Biggest Loser"! Having collaborated with the chief medical officer for three seasons of the show's run, Mickey provides a unique perspective on the science behind the extreme weight loss featured in the competition, and he gives the skinny on how, based solely on their bloodwork, he was able to predict contestants' elimination...

In this episode, Dr. Mickey Urdea asks, "Do we have a quorum?" Quorum sensing, that is! Gather round by the light of the bobtail squid to learn more about this phenomenon which allows certain bacteria to “think” collectively as a group in order to express bioluminescence, competence, virulence, and even pathogenesis, and why Mickey believes that quorum sensing has potential dynamic applications in...

Today, Dr. Mickey Urdea gets to discuss his own achievements as the inventor of “viral load”, or the quantitative measure of viral RNA, and as the leader of the team at Chiron Corporation to first utilize this method in order to monitor the effectiveness of antiviral therapy for HIV patients over time – in fact, it’s the method that is still used today! Come hear the story straight from the source...

In episode 6, we’re not reading tea leaves -  we’re reading saliva! Saliva is a particularly interesting series of compounds that can tell a surprisingly detailed story of a person’s health, and it can be used to test for a variety of different biomarkers which can correlate to a particular disease state, including tests for HIV antibodies, SARS-CoV-2, and even certain forms of cancer! From Yale U...

This week, Dr. Mickey Urdea is exploring eDNA, or environmental DNA, and its uses and applications in diagnostics! Tune in to hear about wastewater testing, just how much DNA can be found outside of a zoo, and why the half-life of DNA means that we’ll never have a Jurassic Park (sorry, kids!).

In Part Two of Dr. Mickey Urdea's foray into the history of bacteria, the focus is on the history of bacterial culture, sequencing, and amplification methods, and how those developments changed how we diagnose and treat bacterial diseases! From the work of two-time Nobel laureate biochemist Fred Sanger to the most advanced sequencing panels of the present day and how they're being utilized, Part T...

In this two-part episode of Interesting Stories in the History of Diagnostics, Dr. Mickey Urdea is discussing bacteria, and why we "Can't Live With 'Em, Can't Live Without 'Em!" Part One of this two-part series canvasses the history of bacteria from the earth's formation to the modern day, and where to find them from the bottom of the Mariana Trench to inside of our own bodies. Tune in for Part Tw...

In the third episode of our "Interesting Stories in the History of Diagnostics" series, Dr. Mickey Urdea expounds on the history of diseases caused by helminths - aka parasitic worms! Helminth diseases still affect more than 1.5 billion people worldwide (24% of the world's population!) today, and properly testing for the presence of worms is a challenge that the diagnostics industry continues to m...

In this installment of our "Interesting Stories in the History of Diagnostics" series, Dr. Mickey Urdea chronicles the history of the use of smell in diagnostics, from Hippocrates to present day cancer-sniffing dogs (yes, really!).

In this first installment of our "Interesting Stories in the History of Diagnostics" series, Dr. Mickey Urdea shares the story of the Dynamizer, a diagnostic device from the early 20th century which parallels the rise and fall of a more modern example - Theranos.