The Rounds Table

Send us Fan Mail Welcome back Rounds Table Listeners! In this throwback episode, Drs. Mike and John Fralick chat about five important research studies published in 2024: Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction (FINEARTS-HF) (0:00 – 4:09) Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA) (4:10 – 9:28) Effects of Semaglutide on...

Send us Fan Mail Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the simultaneous initiation of SGLT2 inhibitors and finerenone (a nonsteroidal mineralocorticoid receptor antagonist) in persons with chronic kidney disease and type 2 diabetes. Here we go! Finerenone with Empagliflozin in Chronic Ki...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back this week with a special podcast episode. Dr. Mike Fralick sits down with Dr. Karim Ladak—rheumatologist and internist, Clinical Assistant Professor at McMaster University, and host of the Rheumatology for the Royal College podcast —to talk about leukocytoclastic vasculitis. Here we go! Questions? Comments? Feedback? We’d love to he...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial exploring the effects of add-on sotatercept in patients with advanced pulmonary arterial hypertension and a high risk of death. Here we go! Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death (0:00 – 5:...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back today with a special Rapid Fire Podcast. This week, Dr. Mike Fralick and guest host Danielle Cutler discuss the top papers from the 2025 American Diabetes Association (ADA) Scientific Session. Hot off the presses, here we go! Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial (0:00 - 6:05) Orforglipr...

Send us Fan Mail Welcome back Rounds Table Listeners! Today we have the next episode in our Clinical Practice Guidelines series. Drs. Mike and John Fralick discuss the top takeaways from the 2024 KDIGO Clinical Practice Guidelines for chronic kidney disease. Here we go! 1. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (0:00 - 24:24) Access the K...

Send us Fan Mail Welcome back Rounds Table Listeners! Today we have another special episode— Trial Files turns two years old this June, and we're celebrating with an episode summarizing the Top 5 RCTs in the Trial Files catalogue to date. Dr. Mike Fralick takes us through five trials in 15 minutes. Here we go! 1. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabete...

Send us Fan Mail Welcome back Rounds Table Listeners! Today we're introducing a new format—the first episode in our Trial Files series, where we provide an overview of a recent Trial Files issue. This week, Dr. Mike Fralick discusses three trials included in a recent throwback issue: opioids versus non-opioids for chronic pain; IV albumin for renal impairment and mortality; and omeprazole bef...

Send us Fan Mail Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published head-to-head trial exploring the safety and efficacy of tirzepatide compared to semaglutide for obesity management. Here we go! Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (0:00 – 7:07). The Good Stuff: Trial Files , a free...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back this week with a special podcast episode. Dr. Mike Fralick sits down with Dr. David Juurlink, pharmacologist and internist, Professor of Medicine at the University of Toronto, and head of the Clinical Pharmacology and Toxicology division at Sunnybrook Health Sciences Centre, to chat about the top drug interactions you might be missi...

Send us Fan Mail Welcome back, Rounds Table Listeners! This week we have a solo episode with Dr. John Fralick, discussing a recently published trial of the GLP-1 receptor agonist semaglutide for the treatment of metabolic dysfunction–associated steatohepatitis (MASH). Here we go! Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis (0:00 – 6:33). The Good Stuff: Go Leaf...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the safety and efficacy of lorundrostat (an aldosterone synthase inhibitor) in treatment of uncontrolled and treatment-resistant hypertension. Here we go! Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypert...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back today with our Classic Rapid Fire Podcast. This week, Dr. Mike Fralick and special guest Dr. Laiya Carayannopoulos from the Intern at Work Podcast and our Medicine Pods collaboration discuss two recent papers: the use of brensocatib (a DPP-1 inhibitor) to treat bronchiectasis, and the effect of alteplase administered 4.5 to 24 hours...

Send us Fan Mail Welcome back Rounds Table Listeners! Today we're introducing a new format—the first episode in our Clinical Practice Guidelines series. This week, Drs. Mike and John Fralick discuss the 2025 ACC/AHA Clinical Practice Guidelines for Acute Coronary Syndrome. Here we go! 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes (0:00 -...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the role of tirzepatide in weight reduction and diabetes prevention in persons with obesity. Here we go! Tirzepatide for Obesity Treatment and Diabetes Prevention (0:00 – 10:24). The Good Stuff: We've launched qMonthly...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial examining liberal fluid intake vs. fluid restriction in chronic heart failure. Here we go! Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial (0:00 – 4:20). And for the Good Stuff: star...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the role of high-dose Vitamin D therapy in reducing disease activity in patients with clinically isolated syndrome (CIS) typical of multiple sclerosis (MS). Here we go! High-Dose Vitamin D in Clinically Isolated Syndrome Typ...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back today with a special Rapid Fire Podcast! This week, Drs. Mike and John Fralick discuss top papers from the 2025  American College of Cardiology (ACC) Annual Scientific Session. Hot off the presses, here we go! Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism (0:00 - 5:55) Dapagliflozin in Patients Undergoi...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back today with our Classic Rapid Fire Podcast! This week, Dr. John Fralick and guest host Dr. Chunpeng Nie discuss two recent papers: resmetirom for the treatment of Nonalcoholic Steatohepatitis (NASH)—now known as Metabolic Dysfunction-Associated Steatohepatitis (MASH)—with liver fibrosis, and the effect of a Mediterranean diet on dise...

Send us Fan Mail Welcome back Rounds Table Listeners! In this throwback episode, Drs. Mike and John Fralick chat about five important research studies published in 2023: Hydrocortisone in Severe Community-Acquired Pneumonia (0:00 – 5:39). Tirzepatide vs Insulin Lispro Added to Basal Insulin in Type 2 Diabetes (5:40 – 8:48). Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (8:49...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back this week with a special podcast episode! Dr. Mike Fralick sits down with Dr. Jeffrey Carson, Distinguished Professor of Medicine at the Rutgers Robert Wood Johnson Medical School and Provost at Rutgers University, to chat about his recent publication -  Restrictive versus Liberal Transfusion in Myocardial Infarction — A Patient-Lev...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back today with our Classic Rapid Fire Podcast! This week, Drs. Mike and John Fralick discuss two recent papers examining the effect of glucagon-like peptide-1 receptor agonists (GLP1's) on patients living with Parkinson’s disease. Two papers, here we go! Trial of Lixisenatide in Early Parkinson's Disease (0:00 – 10:24). Exenat...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. Mike Fralick. This week, he will discuss a paper exploring endovascular treatment (EVT) for acute ischemic stroke due to medium-vessel occlusion. Here we go! Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion (0:00 – 6:02). This episode is sponsored by Northern Ontario Resident Streaml...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back today with our Classic Rapid Fire Podcast! This week, Drs. Mike and John Fralick discuss two recent papers - the role of continuous glucose monitoring for diabetes management in hospital and the benefit of tirzepatide in patients with heart failure with preserved ejection fraction and obesity. Two papers, here we go! Tirzepatide for...

Send us Fan Mail Welcome back Rounds Table Listeners! We are back this week with a special podcast episode! Dr. Mike Fralick sits down with Dr. Amy Yu, a Stroke Neurologist, Clinician-Scientist, and Associate Professor of Medicine at the University of Toronto and Sunnybrook Hospital, to chat about her hot-off-the press publication - Population-Level Screening for Diabetes and Dyslipidemia After Pr...