The Optispan Podcast with Matt Kaeberlein

In the final installment of this three-part series, Matt and Kim Celmer explore the essential topic of hormonal health for women, highlighting its impact on both overt and silent symptoms of hormonal changes. Celmer offers practical advice for initiating meaningful conversations with healthcare providers about hormone levels with both diving into the intricacies of hormone replacement therapy (HRT...

Subscribe to our channel: https://www.youtube.com/@optispan Matt Kaeberlein & Nick Arapis discuss the potential of new drugs aimed at extending the lifespan of dogs and cats. The conversation highlights recent advancements, including Loyal’s injection-based treatment targeting the IGF-1 hormone, which may add years to a dog’s life. They also address misconceptions regarding claims about cat li...

Subscribe to our channel: https://www.youtube.com/@optispan In this episode of the Optisan Podcast, Dr. George Sutphin discusses biological age tests, focusing on epigenetic and glycan age assessments. The conversation explores the accuracy, relevance, and implications of these tests for understanding biological versus chronological age. Key topics include the limitations of current biomarkers, th...

Subscribe to our channel: https://www.youtube.com/@optispan In this episode with our guest Dr. Thomas Seager, we delve into the transformative power of cold plunge therapy and its profound effects on resilience and longevity. We explore real-life case studies, including lessons learned from infrastructure failures like Hurricane Katrina and the Oroville Dam crisis. Discover how psychological resil...

Subscribe to our channel: https://www.youtube.com/@optispan Related Episode(s):Biological Age & what it REALLY means | 9 - Longevity Science #3: https://youtu.be/DcxgEwQKx8Q?si=y1iF4RviJc0n__gW In this deep dive, Matt examines the growing trend of direct-to-consumer biological (epigenetic) age testing kits, exploring their purpose, popularity, and limitations. He outlines his experimental desi...

Subscribe to our channel: https://www.youtube.com/@optispan In this episode, Matt sits down with Thomas Seager, an associate professor at Arizona State University (ASU), to explore the challenges and future directions of healthcare. Drawing from his background in environmental engineering and public health, Thomas discusses the pressing health issues affecting longevity in Americans and a potentia...

Subscribe to our channel: https://www.youtube.com/@optispan Grief: one of the most profound emotions humanity shares; a universal experience that transcends time, culture, and place; a phenomenon as ancient as human existence. Grief is as intrinsic to the human experience as joy or hope, and no one escapes it—to grieve is to be human. In this episode, Matt and Nick discuss their recent personal ex...

Subscribe to our channel: https://www.youtube.com/@optispan Related episode: People are GETTING THIS WRONG about Supplements & My Supplement List: https://www.youtube.com/watch?v=_UXk_ynCNUs In this episode, Matt sits down with naturopathic doctor and primary care provider Kim Celmer to discuss the distinct approach naturopathic doctors (NDs) bring to patient care, addressing common misconcept...

Subscribe to our channel: https://www.youtube.com/@optispan Related episode: Defining "Healthspan" & its role in LIVING LONGER: https://www.youtube.com/watch?v=cI6CNFeBl88 Author and physician Peter Attia popularized the concept of "Medicine 3.0", the third in a series of distinct phases—Medicine 1.0 and Medicine 2.0 included—that describe the evolution of medicine as we know it. In this episo...

Subscribe to our channel: https://www.youtube.com/@optispan How much longer might humans live? This question has fascinated scientists, philosophers, and dreamers for centuries. The average human lifespan has already increased dramatically over the past hundred years thanks to advances in medicine, public health, and technology, and the prospect of radically extending human life remains one of hum...

Subscribe to our channel: https://www.youtube.com/@optispan Here's another Ask Matt Anything episode, with questions from Nick for Matt about topics ranging from the nitty-gritty of bloodwork and workout schedules to bigger-picture questions about upper limits to human lifespan, issues with the US healthcare system, and incentives for food companies to prioritize healthy options. Producers: Tara M...

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: Brain Disorder Expert: Tackling Alzheimer's & Other Brain Disorders with LITHIUM: https://www.youtube.com/watch?v=ebj-3MuAKRs Check out Woodinville Psychiatric: https://www.woodinvillepsychiatric.com/ Matt and psychiatrist Jon Berner discussed the potential of rapamycin and ketamine for treating severe depression and...

Subscribe to our channel: https://www.youtube.com/@optispan Check out the New York Times article: https://www.nytimes.com/2024/09/24/well/live/rapamycin-aging-longevity-benefits-risks.html Related episodes: “Zombie” Senescent cells may play HUGE role in LIVING LONGER, Here's How: https://www.youtube.com/watch?v=-H6cDIl6pgo NEW PEARL Trial Results: Your Questions Answered on Aging with Rapamycin fo...

Subscribe to our channel: https://www.youtube.com/@optispan Check out the study on caffeine and cortisol secretion: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2257922/?__hstc=3584879.1bb630f9cde2cb5f07430159d50a3c91.1522713601929.1522713601930.1522713601931.1&__hssc=3584879.1.1522713601932&__hsfp=1773666937 Check out James Hoffman's views on delaying caffeine intake in the morning: https...

Subscribe to our channel: https://www.youtube.com/@optispan Check out the paper: https://www.sciencedirect.com/science/article/pii/S0092867424009140?casa_token=6qa0LtsLh8QAAAAA:Iid3EX1qav1JTfkO5Skj787iUo6bJjD4dAgjvK_2ix5JirSEakRCc92m_W0G5CgNdLZR-RT4B4Q In September 2024, the scientific journal Cell published a paper suggesting that metformin slows the pace of biological aging in male primates. Met...

Subscribe to our channel: https://www.youtube.com/@optispan We recently came across a study published in the European Journal of Nutrition that examined the relationship between plant and animal protein intake and measures of biological aging. The study, which uses data from the UK Biobank, a long-term database of biological data from half a million participants in the United Kingdom, found that a...

Subscribe to our channel: https://www.youtube.com/@optispan More about the Dog Aging Project: https://dogagingproject.org/ The Dog Aging Institute: https://dogaginginstitute.org Enroll your dog in the Dog Aging Project: https://redcap.dogagingproject.org/surveys/?s=DYYDHK8HAP We get lots of feedback and questions about the Dog Aging Project (DAP) from viewers, so we wanted to provide an update abo...

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: Current Healthcare ISN'T CUTTING IT: How Optispan is REVOLUTIONIZING it: https://www.youtube.com/watch?v=yc2kiKsm-Z0 Aging Expert Explains How Healthcare got it ALL WRONG: https://www.youtube.com/watch?v=PAEx-5CdX94 Your health doesn't need to be complicated. With so much conflicting information out there, it's easy to f...

Subscribe to our channel: https://www.youtube.com/@optispan Check out the PEARL trial webinar with Dr. Z of AgelessRx, Oliver Medvedik of Genspace, and Matt Kaeberlein: https://www.youtube.com/watch?v=dEXBFlQOTf4&t=1217s Check out the preprint discussing PEARL trial results after one year: https://www.medrxiv.org/content/10.1101/2024.08.21.24312372v1 Check out the PEARL trial listing: https://...

Subscribe to our channel: https://www.youtube.com/@optispan Check out the paper: https://www.nature.com/articles/s41586-024-07701-9.pdf Related episodes: The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21: https://youtu.be/Nf1GhkAFiWY A recent paper demonstrating that injecting older mice with an anti-IL-11 drug extended their median lifespan made a splash in the gerosci...