The Life Scientific

Is it true that some people put on weight more easily than others? And if so why? It's a question that's close to many of our hearts. And it's a question that medical researcher, Professor Sadaf Farooqi is trying to answer. In 1997, Sadaf noticed that two children she was studying lacked the hormone leptin. From there, she went on to discover the first single gene defect that causes obesity. For m...

Jan Zalasiewicz, Professor of Palaeobiology at Leicester University, talks to Jim al-Khalili about the Anthropocene, the concept that humans now drive much geology on the earth. He's one of the leading lights in the community of scientists who are working to get the Anthropocene, the Age of Man, recognised. They discuss the controversy about the date of when it began- some say it was a thousand ye...

The Cassini mission into deep space has witnessed raging storms, flown between Saturn's enigmatic rings and revealed seven new moons. And, thanks in no small part to Professor Michele Dougherty, it's made some astonishing discoveries. For the last twenty years, Michele been responsible for one of the key instruments on board Cassini - the magnetometer. In 2005, she spotted a strange signature in t...

The US science superstar, Neil de Grasse Tyson grew up in the Bronx, and studied astrophysics at Harvard, Columbia and Princeton Universities before becoming director of the Hayden Planetarium in New York City. But he's best known for his TV and movie appearances, his books, podcasts and his tweets or 'scientific droppings' as he likes to call them. He has over 6 million followers on Twitter and i...

How do we know where we are? The question sounds simple enough. But there's much more to it than simply looking around. Our sense of place is embedded in the very structure of our brains, in such a way that we can remember the exact place we used to play as a child, even if the neighbourhood has been transformed and few of the original visual cues remain. The park you played in as a child may now...

Plastic Bags and the DNA in our cells are both polymers, very long molecules ubiquitous in nature and in their synthetic form, in materials like polythene, perspex and polystyrene. Professor Dame Julia Higgins has spent a lifetime researching the structure and movement of polymeric material. Trained as a physicist, Dame Julia was one of the early researchers in polymer science and throughout her c...

In a career of over fifty years Sir Roger Penrose has changed the way we see the Universe. He carried out seminal research on black holes and the big bang, and he's questioned the current received wisdom on some of the most important ideas in science, such as quantum mechanics, artificial intelligence and where consciousness comes from. His ideas in geometry directly influenced the work of the Dut...

Fungi are responsible for rotting fruit, crumbling brickwork and athlete's foot. They have a mouldy reputation; but it's their ability to destroy things that enables new life to grow. 90% of all plants depend on fungi to extract vital nutrients from the soil. And it's probably thanks to fungi that the first plants were able to colonize land 450 million years ago. Professor Lynne Boddy shares her p...

Dolly the sheep was born near Edinburgh, twenty years ago this summer. She was the first mammal to be cloned from an adult animal, (named after Dolly Parton because she was created from a breast cell). And became a global media star, inspiring both amazement that an animal be created with three mothers but no father,and fear. Many worried about where such a development might lead. The papers repor...

We share 99% of our DNA with the chimpanzee and the bonobo. And yet we're often surprised to learn that apes, like us, can be both kind and clever. Behavioural biologist and best-selling author, Frans de Waal has spent many years observing our closest living animal relatives. He pioneered studies of kindness and peace-making in primates, when other scientists were focussing on violence, greed and...

Inside a Victorian sewer, with fat deposits sliding off the ceiling and disappearing down the back of his shirt, Trevor Cox had an epiphany. Listening to the strange sound of his voice reverberating inside the sewer, he wondered where else in the world he could experience unusual and surprising noises. As an acoustic engineer, Trevor started his career tackling unwanted noises, from clamour in the...

Despite decades of conservation work, in zoos and in the field, the rate at which species are going extinct is speeding up. Georgina Mace has devoted her Life Scientific to trying to limit the damage to our planet's bio-diversity from this alarming loss. For ten years she worked on the Red List of Threatened Species, developing a robust set of scientific criteria for assessing the threat of extinc...

Self-taught Professor of Developmental Cognitive Neuroscience, Faraneh Vargha-Khadem has spent decades studying children with developmental amnesia. Her mission: to understand how we form memories of the events in our past, from things we've experienced to places we've visited and people we've met. She talks to Jim about the memories we lay down during our lives and the autobiographies stored in o...

Hazel Rymer has journeyed closer to the centre of the earth than most, regularly peering into the turbulent, fiery world than makes up the earth's core. By taking measurements of micro-gravity on, and inside, volcanoes all over the world, she hopes to better understand why they erupt and what happens when they do. Having lost a close colleague to a random volcanic eruption, she appreciates the ris...

Nick Davies has been teasing apart the dark relationship between the cuckoo and the birds it tricks into bringing up its young, for more than three decades. The Professor of Behavioural Ecology at the University of Cambridge has spent more than 30 springs and summers on nearby fenland of watching, recording and crucially experimenting. Nick's studies have deployed simple yet ingenious experiments,...

Half a century after the search for gravitational waves began, scientists confirmed that they had finally been detected in February 2016. Physicists around the world were ecstatic. It was proof at last that Einstein was right: the tiny ripples in the fabric of spacetime that he predicted a hundred years ago are real. And now that we can detect them, a new era for astronomy is anticipated. Traditio...

Marcus du Sautoy wasn't particularly good at maths at school; but a teacher spotted his aptitude for abstract thought and he started reading, and enjoying, journals filled with mathematical proofs. His thesis on the mathematics of symmetry launched him as a world class mathematician. And before he dies he wants to know: can you predict the properties of the next symmetrical object that could possi...

Lawrence Krauss has had an unusual career for a cosmologist. Not content with dreaming up theoretical models of the Universe, and writing bestselling science books, he gathers audiences of thousands for his talks with leading figures, from Noam Chomsky to Johnny Depp. And soon, he will star as an evil scientist in the film 'Salt & Fire' directed by Werner Herzog. Inside the world of physics, K...

Barely a month goes by without news of another catastrophic flood somewhere in the world, like the Boxing Day tsunami in 2004 or the flooding of New Orleans with Hurricane Katrina a year later, and the role of climate change is often mooted. Here in the UK this winter, flood victims were once again caught in a cycle of despair and anger as they tried to make sense of why their homes were flooded a...

Before Helen Sharman replied to a rather unusual radio advertisement her life was, in many ways, quite ordinary. She was working as a chemist in a sweet factory, creating and testing flavours. Much to her surprise, her application to be an astronaut was successful and two years later, following an intense 18 month training course at a military base just outside Moscow, she was selected for Project...

All the information that's needed for life is written in our DNA. But how do we get from DNA code to biological reality? That's the job of the ribosomes - those clever molecular machines that are found in every living cell. And in 2008 Venki Ramakrishnan was awarded the Nobel Prize for determining their structure. Jim talks to Venki about the frantic race to crack the structure of the ribosome, pr...

When George Davey-Smith started work as an epidemiologist, he hoped to prove that the cause of coronary disease in South Wales soon after the miner's strike was Thatcherism. The miners said they thought it was a combination of having a poor constitution and bad fortune. Thirty years later, George admits he would have done well to listen to them. Having spent decades studying the influence on our h...

Dr Nick Lane is attempting to answer one of the hardest questions in science. How did life on earth begin? You might think that question had been solved by Darwin in the 19th century. He wrote that he thought life might have started on earth "in a warm little pond", where all the necessary ingredients: water, sunlight and nutrients combined in this "primordial soup" to create the very first biomol...

Naomi Climer is one of the most senior British women engineers working in the communications industry, and after decades working on major projects she's left the world of business to become the first female president of Institution of Engineering and Technology (the IET). As part of her presidency, Naomi has launched a campaign called - Engineer a better World - to make us realise that engineering...

With the Zika epidemic in Brazil being declared an international health emergency just months after the recent Ebola epidemic in West Africa, Jim Al-Khalili talks to Professor Peter Piot about a lifetime spent trying to stop the spread of deadly viruses. Peter came across a strange new virus in 1976 when he was working in a small lab in his home town, Antwerp. Weeks later he was in Zaire meeting p...