The a16z Show

Your brand, says head of a16z marketing and Outcast Agency co-founder Margit Wennmachers, is what people say about you when you're not in the room. And it's going to happen, whether you choose to have an active part in it or not. But what does this mean at an individual, not just company/product level? In this episode of the a16z Podcast, Wennmachers and Outcast CEO Alex Constantinople -- both lon...

Starbucks supposedly spends more on healthcare than it does on coffee beans. And 20 years ago, says Rajeev Singh, CEO of Accolade, healthcare was 10% of GDP; today it’s 19% -- that's nearly one-fifths of our gross domestic product. So what tools do we have to address the high costs of health care, especially as stakeholders increasingly look for value-based care? This episode, recorded at our a16z...

In this episode of the a16z Podcast introduced by Vijay Pande (based on a presentation at our summit event), Russ Altman, Stanford professor of bioengineering -- and former chairman of their Bioengineering Department -- takes us on a short but deep tour of the possibilities of genomics in drug discovery. Including how building a large bank of human genetic variations will change our understanding...

The irony of our systems working so well -- technological, corporate, and yes, even political -- is that we've become too comfortable: matching to others just like us, producing less, taking fewer risks. But isn't the very point of technology to make our lives more comfortable? Yes... until "we" -- whether an entire class, generation, ethnic group, or country like the U.S. -- become a li...

Humans have always wanted to enhance themselves -- from getting nutrition just-right to optimizing their performance, whether in sports or health or work. And food is a big part of all that. But our current systems of food production (and consumption) are far from efficient and sustainable let alone optimizable. That's where a whole new generation of wearable/ bio-feedback, food and nutrition, foo...

Imagine, for a moment, an alternative universe: One where Netflix got disrupted by some other streaming-content company that made its DVD rental business irrelevant. But that's just a counterfactual. What happened instead is that Netflix cannibalized (or rather, "hybridized") its own core business to make room for a more strategic one given where the tech was going. Given how rare it is...

Evolution and technology have allowed our human species to manipulate the physical environment around us -- reshaping fields into cities, redirecting rivers to irrigate farms, domesticating wild animals into captive food sources, conquering disease. But now, we're turning that "innovative gaze" inwards: which means the main products of the 21st century will be bodies, brains, and minds....

It's been nearly 15 years since the Human Genome Project was completed. But "are we there yet" in the golden age of genomics? What did we think we'd have by now, what do we actually have, and what do we really still need to make genomics live up to its promise? Well, one thing we now understand is that our DNA isn't static; in fact, it changes at an absolutely crazy rate. We also need to...

The hardest thing about pivots (major shifts in company/product direction) isn't just the actual pivot. It's the courage to make the decision... and being honest with yourself as a CEO. Especially since, no matter how great the team or board or even customers may be, it's lonely: You're the only one in the position to synthesize the knowledge; nobody else has the data and the insight put together...

The modern enterprise holds all sorts of applications, devices, and workflow needs. How should we be thinking about securing infrastructure -- and identity -- in this context, for entities like major news media outlets or financial institutions such as News Corp or NASDAQ? Well, this episode of the a16z Podcast brings those voices together: Frederic Kerrest, cofounder and COO of Okta; Brad Peterso...

Thanks to freeways, cities became something to get through instead of something to get to. Now, as the next transportation revolution -- from rivers to trains to cars to autonomous cars -- promises to change the face of our cities, what happens to car culture, infrastructure, and more? Who owns what, who pays? And what about the design -- and product management -- challenges, whether it's designin...

In the age of the internet -- where information is freely available online, and connections between sellers and buyers of software products are visible on LinkedIn -- do analysts really matter? Do they play a role in decision-making for purchases from smaller vendors like tech startups, especially given the rise of the developer as a buyer? Or what if you're trying to create a new category ... do...

Once upon a time, Robert Stromberg got a phone call from "Jim" Cameron (aka James Francis Cameron of Terminator and Titanic fame) about a little project called Avatar. Before he knew it, he was responsible for designing the organic world of Pandora, from bioluminescent plants to lush mountaintops. That was when Stromberg realized how much more technology could do, when ready, for creatin...

"Punch above your weight" -- If there's one thing public relations (PR) should help startups and founders do, it's that. Unfortunately, some companies are actually punching below their weight when there's a strong company, founder, product ... yet nobody knows about let alone talks about you. Or worse, someone else defines you first. Or you just become a hype machine. So what conversatio...

The building blocks for VR and AR are finally here -- but the content is just beginning. So everything you'll actually experience and consume in these new mediums over the next few years is being built right now. Formats aren't yet defined or locked down, and the field is bubbling up with experiments in forms, formats and genres, from narrative to games to live events. As we begin to have real tim...

How to think about business policy and top-of-mind issues for the tech industry, given a new president? From what agencies matter for startups and VC to what the first 100 days (and next two years!) look like, a16z managing partner Scott Kupor and president and CEO of the National Venture Capital Association (NVCA) Bobby Franklin share what happens between elections and when the reality of the Was...

How to think about tech policy and top-of-mind issues for the tech industry, given a new president? From what agencies matter for different tech domains -- e.g., autonomous cars, drones, fintech, healthcare -- to recent staffing moves, the a16z Policy and Regulatory Affairs team shares their views in this episode of the podcast. What happens to tech policy when you have a dominant Republican prese...

"Mobile-first" (and now too AI-first) has been a mantra of sorts in design, but what does that mean at a company, product management, and competitive level? Especially when someone in company X will always say "we should do what Y did" -- even if they have no idea let alone data why Y did it. And while designing for screens is "like growing a carp in a bathtub" (will...

The largest asset class in the United States is owner-occupied real estate, yet options for homeowners accessing this are very binary right now: either own 100% of your home (with a mortgage), or own nothing. And when people do “own”, that ownership is often skewed by debt. Of course, debt works out great for some, given their risk profiles and potential upside (if the house keeps appreciating); b...

From the significance of Google DeepMind's AlphaGo wins to recent advances in "expert-level artificial intelligence" in playing an imperfect/ asymmetric information game like poker, toys and games have played and continue to play a critical role in advancing machine intelligence. One of the pioneers in this area among others is the Alberta Innovates Centre for Machine Learning -- now the...

What (on earth) does it take to get a signal to Pluto? Stanford senior scientist and astronomer Ivan Linscott, part of the team that ran the radio science experiment on the New Horizons probe, shares in conversation with a16z's Frank Chen all the nitty gritty details about their project using Ruse radio transmissions to gather info about Pluto. Listen in on exactly what it really takes to do so --...

As companies expand out from the internet into the rest of the economy — the proverbial bits to atoms — “the business models are becoming more complicated, more interesting, more payment based”, observes Patrick Collison, CEO and co-founder of payments platform Stripe, which enables apps/websites to programmatically move money around. But as such companies become “the operating platform for commer...

As people live longer, aging is more top of mind than ever. This is especially true for the "sandwich generation" wedged between caring for aging parents as well as young children at the same time. The fact is, the 65+ year old population (but don't you dare homogenize a multi-decade age group!) will double over just the next 15-20 years. So how does this fit into our current healthcare...

"We throw around words like 'crisis' very easily, but this is a global crisis, and it is of historic proportions," says current U.S. Deputy Secretary of State Tony Blinken about the refugee crisis (for which he and his department mobilized a response that significantly accelerated government efforts to assist refugees, as well as engage the tech sector). "People don't realize that b...

Nature is the ultimate complex system, of course — but with today’s technology, it’s now provided us with an “incredible toolkit” of different molecules that material scientists can treat like Legos to make some really interesting products. One of those is a protective layer for fruits and vegetables that extends shelf life and freshness. Because all produce is seasonal, it’s perishable — so there...