Stem Cell Channel (Video)

While exercise helps us stay healthy, what is happening on the molecular level? Matthew A. Romero, Ph. D., shares his work to understand how muscle in general and other cells specifically are transcriptionally regulated by exercise and how this affects their general behavior and how this is impacted by diseases such as obesity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID:...

Gaia Navarino shares her work on disorder-causing genetic mutations at the system, cellular and molecular level. With a focus on autism spectrum disorder, she explains techniques used to identify common pathophysiological mechanisms in ASD and how that could provide a framework for the development of effective pharmacological therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [...

Ali H. Brinvanlou, Ph. D., shares his work using in vitro attached human embryos and genome-edited synthetic embryos derived from human embryonic stem cells to learn the molecular, cellular, and embryological basis of early human development. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38324]

Have questions about publishing in academic journals? Sheila Chari, Ph. D., editor in chief of Cell Stem Cell, explains the process from pre-submission through publication. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38722]

Tim Fenton, Ph. D., University of Southampton, shares his work on the roles of APOBEC3 genes. Hear how he is investigating APOBEC regulation and function in keratinocytes. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38724]

How do visions and norms of scientific progress inform, encourage or constrain democratic governance of science? How do questions of warrant, purpose, and benefit get asked and answered? Andy Murray, Ph. D., sits down with Carrie Wolinetz, Ph. D., National Institutes of Health (NIH), Maria Millan, M.D, California Institute for Regenerative Medicine (CIRM, Derek Thompson, The Atlantic, and Sheila J...

How do we set practical policies that allow scientific discovery to thrive while keeping an eye to risks and benefits for all? Carrie Wolinetz, Ph. D., National Institutes of Health (NIH), looks at current and past policy and shares her insights on the democratic governance of science. Series: "Stem Cell Channel" [Science] [Show ID: 38745]

How do structures and practices of privatization and commercialization affect capacities for deliberating and defining limits? How do questions of purpose, desirability, and public good relate to the prioritization of commercialization and profit? What means, formal and informal, exist for setting limits or seeking alignment between public and private interests? Krishanu Saha, Ph. D, Rosemarie Gar...

How do research communities contend with controversial science? J. Benjamin Hurlbut, Ph. D., Arizona State University, Alysson Muotri, Ph. D., UC San Diego, Matthew Porteus, M.D., Ph. D., Stanford University, and Jacob (Yaqub) Hanna, M.D., Ph. D., Weizmann Institute of Science, explore controversial case studies and the limitations of scientific deliberation/dissent/ambivalence. Series: "Stem Cell...

The identity of somatic and pluripotent cells can be epigenetically reprogrammed and forced to adapt a new functional cell state by different methods and distinct combinations of exogenous factors. The aspiration to utilize such in vitro reprogrammed pluripotent and somatic cells for therapeutic purposes necessitates understanding of the mechanisms of reprogramming and differentiation and elucidat...

Systems neuroscience aims to understand how brain cells and circuits are organized to produce behavior in living organisms. Julio Martinez-Trujillo, M.D., Ph. D., shares his research studying how neurons interact with one another and other cell types within a circuit during ex vivo and in vivo conditions. He also looks to the future and discusses how stem cell technologies can provide unique acces...

As a mechanical engineer, Jin-Hyung Shim, Ph. D. has a unique perspective on tissue and organ regeneration. He discusses the present and potential of 3D printed biomaterials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38321]

Shiri Gur-Cohen, Ph. D., UC San Diego, explains how her lab studies how epithelial stem cells communicate with their vascular microenvironment to advance regeneration and combat metastatic diseases. Series: "Stem Cell Channel" [Education] [Show ID: 38409]

How can we better understand the earliest stages of human development? Jianping Fu, Ph. D., University of Michigan, discusses his work using stem cell-derived embryoids. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38320]

Alysson Muotri discusses modeling Pitt-Hopkins syndrome (PTHS) using stem cells and brain organoids. He shares how rescuing TCF4 expression with CRISPR-mediated epigenetic induction of AAV vector delivery provides a gateway for targeted therapeutics for PTHS and related conditions. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38516]

Thomas C. Südhof, M.D., Stanford University, discusses facets of the fundamental cell biology of ApoE and APP analyzed in stem cell-derived human neurons. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38405]

The human placenta may hold important clues to the health of both mothers and babies. Mana Parast, M.D., Ph. D., discusses placental development, what we can learn from pathologic evaluation of the placenta after delivery, and modeling the placenta with stem cells. Karen Mestan, M.S., M.D., shares highlights in neonatal medicine, how to use the placenta as a diagnostic tool to improve the immediat...

Derrick J. Rossi, Ph. D., President and Chief Executive Officer of Convelo Therapeutics has a long history of pioneering methods to make stem cell–based treatments for disease a reality. He shares stories of science making its way from the lab and into biotech with the intention of improving the lives of patients. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38404]

Frank Furnari, Ph. D., of UC San Diego, shares his work using stem cells as a vehicle to generate models of brain cancer. Focusing on glioblastoma, he explains how tumor avatars could lead to new therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38514]

Jeffrey Magee, M.D., Ph. D., of Washington University in St. Louis, discusses how mechanisms that regulate hematopoietic stem cells change with age and how this shapes the biology of pediatric leukemia. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38398]

CIRM-funded Alpha Stem Cell Clinics are a network of California medical centers that specialize in delivering stem cell clinical trials to patients. Sandra Dillon shares how their work has impacted treatments for her rare cancer. Maria T. Millan, M.D., Mehrdad Abedi, M.D., Daniela A. Bota, M.D., Ph. D., Sheila Chari, Ph. D., Noah Federman, M.D., Catriona Jamieson, M.D., Ph. D., Sean Turbeville, Ph...

How do epithelial stem cells enable renewal and regeneration of organs in adults? Ophir Klein, M.D., Ph. D., explains his research in stem cell-fueled tooth renewal and intestinal stem cells. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38318]

What if we could trick stem cells into thinking they were young again? What would the impact be on human health and aging? Shiri Gur-Cohen, Ph. D., shares her work. Series: "Women in Science" [Health and Medicine] [Show ID: 38216]

What challenges does aging pose to both individuals and society at large? What causes aging at the cellular and molecular level? Stem cell research is be key to finding solutions that increase our healthspan and change how we think about aging. Robert A.J. Signer, Ph. D., shares what is on the horizon. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38215]

Su-Chun Zhang, M.D., Ph. D., shares how neural transplantation cell therapies can be used to treat neurological conditions such as Parkinson's disease. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38203]