David Brühlmann - CMC Development Leader, Bioprocess Expert, Business Strategist

Smart Biotech Scientist | The CMC and Bioprocessing Podcast for Process Development and Manufacturing Leaders

Science EN ↓ 269 episodes

The go-to CMC and biomanufacturing podcast for bioprocess development scientists and CMC leaders scaling biologics into regulatory-ready therapies with less trial and error. Practical, execution-focused, and strategic guidance on CMC development, tech transfer, scale-up, GMP readiness, CDMO partnerships, and manufacturing economics for biologics, cell and gene therapies, cultivated meat, and biomaterials. Hosted by Dr. David Brühlmann, CMC strategist, former Bioprocess Innovation Manager at Merck, PhD in glycoengineering, and close to 20 years of biomanufacturing experience. Smart Biotech Scie...

Author

David Brühlmann - CMC Development Leader, Bioprocess Expert, Business Strategist

Category

Science

Podcast website

smartbiotechscientist.com

Latest episode

Jul 9, 2026

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Episodes

18: How Extracting Gold From Your Data Accelerates Process Development w/ Ioscani Jiménez del Val - Part 2 11.01.2024

In part 2 of this interview with Ioscani, Assistant Professor at the School of Chemical & Bioprocess Engineering, University College Dublin, we delve into the art and science of accelerating process development through the strategic extraction of valuable insights from data. Our guest, a seasoned expert in computational modeling, unfolds the intricate dance between quality by design principles...

17: How Extracting Gold From Your Data Accelerates Process Development w/ Ioscani Jiménez del Val - Part 1 09.01.2024

Join us as we unravel the complexities of computational methods in bioprocessing, featuring cutting-edge research on glycosylation and process development. Ioscani Jiménez del Val, Assistant Professor at the School of Chemical & Bioprocess Engineering, University College Dublin, explores the intricacies of creating computational models, closing the loop, and optimizing with numerical methods....

16: Bacon Without Pigs? Innovations in Cultivated Meat Manufacturing with Beat Thalmann - Part 2 21.12.2023

In part 2, we explore the details of cost reduction in cultivated meat manufacturing, with a focus on two important factors: media and simplified bioreactors. Beat Thalmann, a passionate innovator and serial entrepreneur specializing in the development of animal-free cell culture systems, highlights the strategic importance of selecting the right cells and advocates for a streamlined process that...

15: Bacon Without Pigs? Innovations in Cultivated Meat Manufacturing with Beat Thalmann - Part 1 19.12.2023

Is bacon without pigs the future? In this episode, join us as Beat Thalmann, a passionate innovator and serial entrepreneur specializing in the development of animal-free cell culture systems, unveils the exciting possibilities. Discover how he overcomes the challenges of production and envisions a future where cultivated steak competes on price. Beat Thalmann provides an insider's perspectiv...

14: Digital Transformation in Biomanufacturing: A Rapidly Moving Tech Frontier w/ Abhijeet Satwekar - Part 2 14.12.2023

Are you struggling to unlock the full potential of Process Analytical Technology (PAT) in biomanufacturing? Look no further! Join us for a game-changing conversation with Abhijeet Satwekar, an Innovation Manager at Merck Guidonia-Rome, Italy. Discover how PAT can revolutionize your decision-making, accelerate development timelines, and propel your biotech company to new heights. Key Learnings: Dec...

13: Digital Transformation in Biomanufacturing: A Rapidly Moving Tech Frontier w/ Abhijeet Satwekar - Part 1 12.12.2023

Wondering how you can leverage the immense potential of the rapidly evolving world of digital transformation in biomanufacturing? Join us as we explore the frontiers of technology and innovation with Abhijeet Satwekar, Innovation Manager at Merck Healthcare. Discover how cutting-edge digital technologies are revolutionizing bioprocesses, optimizing efficiency, and ensuring consistent product quali...

12: From Lab to Patient: Steve Oh’s Guide to Mastering Cell Therapy Process Development - Part 2 07.12.2023

Welcome back to the second part of our exclusive interview with Steve Oh, former Institute Professor at the Bioprocessing Technology Institute (BTI) at the Agency for Science and Technology (A*STAR) and now Scientific Advisor to several international companies. In this episode, Steve dives deep into the challenges of manufacturing different cell types, sharing insights gained from his groundbreaki...

11: From Lab to Patient: Steve Oh’s Guide to Mastering Cell Therapy Process Development - Part 1 05.12.2023

Dive into the world of cell therapy process development with Steve Oh, former Institute Professor at the Bioprocessing Technology Institute (BTI) at the Agency for Science and Technology (A*STAR) and now Scientific Advisor to several international companies, as he shares thought-provoking perspectives and predictions on technologies that will impact the biotech industry. In this riveting conversat...

10: Revolutionizing Cell-Line Development: Unleashing the Power of Nanopens and Microenvironments w/ Tanner Nevill - Part 2 30.11.2023

Unlock the secrets of cell-line development with Tanner Nevill, the SVP of Applications at Bruker Cellular Analysis and one of the primary inventors and developers of the Beacon Optofluidic Platform. In this interview, Tanner delves into the transformative power of nanopens and microenvironments in cell-line development. Key Takeaways: Nanopens Redefining Norms: Tanner introduces the game-changing...

09: Revolutionizing Cell-Line Development: Unleashing the Power of Nanopens and Microenvironments w/ Tanner Nevill - Part 1 28.11.2023

In this episode, Tanner Nevill, the SVP of Applications at Bruker Cellular Analysis and one of the primary inventors and developers of the Beacon Optofluidic Platform, shares insights into revolutionizing cell-line development through nanopens and microenvironments. Key Takeaways: Challenging the Status Quo: Tanner challenges conventional thinking, highlighting the limitations of planar cell cultu...

08: Unveiling the Power of Microcarriers: Scaling Up Adherent Cell Cultures in Bioprocessing w/ Payar Radfar - Part 2 23.11.2023

In the second part of our insightful interview with Payar Radfar, CEO of Smart MCs, we delve into the practical steps of developing adherence cell cultures for bioprocessing scalability. Payar emphasizes the critical need for patience and a methodical approach, recounting how many clients rush into large-scale cultures prematurely. The key takeaways include: 1. Start Small, Stay Patient: Begin wit...

07: Unveiling the Power of Microcarriers: Scaling Up Adherent Cell Cultures in Bioprocessing w/ Payar Radfar - Part 1 21.11.2023

In this episode, we explore the world of adherent cell cultures with Payar Radfar, CEO of Smart MCs. Smart MCs specializes in customized biomaterials and microfluidic solutions. Payar shares his unique journey in the biotech industry, driven by his passion for improving people's health. Key Takeaways: 1. Revolutionizing Bioprocessing: Payar discusses the challenges scientists face when transi...

06: Hybrid Modeling: The Key to Smarter Bioprocessing w/ Michael Sokolov - Part 2 16.11.2023

In the second part of our conversation with Michael Sokolov, the co-founder and COO of DataHow, we dive into practical insights on leveraging hybrid modeling in bioprocessing. You will discover: 1. Starting Small, Dreaming Big: Even in smaller companies, you can start with a minimal number of reactors and still leverage hybrid modeling effectively. Whether it's just a few shakers or a handful...

05: Hybrid Modeling: The Key to Smarter Bioprocessing w/ Michael Sokolov - Part 1 14.11.2023

In this insightful conversation, we explore how to accelerate bioprocess development and enhance manufacturing using hybrid modeling. Our guest, Michael Sokolov, COO of DataHow (a spin-off company from ETH Zurich), shares valuable insights. Discover the three major takeaways that could transform the bioprocessing industry: 1. Unlocking the Power of Hybrid Modeling : Michael Sokolov introduces the...

04: How to Master Biotech Scale-up Without Guesswork w/ Leonardo Sibilio - Part 2 09.11.2023

In today's episode, we continue our fascinating conversation with Leonardo Sibilio, CEO of Biotech Academy and CSO at BetaPro Consulting. We delve into the pivotal role of structured training in the dynamic biotech industry. In this episode, you'll discover: - Foundation of Success : Leonardo emphasizes the importance of a strong foundation in GMP and an understanding of biotech facility...

01: Unlock the Power of Rational Media Design in Bioprocessing w/ Tom Fletcher - Part 1 07.11.2023

In this episode with Tom Fletcher, R&D Director, Process development, Fujifilm Irvine Scientific, we delve into the world of bioprocessing. Tom shares insights into the transformative power of rational media design. From the complexities of bioprocess development to the game-changing potential of AI, this interview is a treasure trove of knowledge for both scientists and engineers. You will le...

02: Unlock the Power of Rational Media Design in Bioprocessing w/ Tom Fletcher - Part 2 07.11.2023

Welcome to a fascinating Smart Biotech Scientist episode! In this conversation, we dive deep into the nuts and bolts of rational media development with our guest, Tom Fletcher, R&D Director, Process development, Fujifilm Irvine Scientific. Together, we explore the immense potential of Rational Media Design and how it's transforming the industry. Here are three major takeaways from this ep...

03: How to Master Biotech Scale-up Without Guesswork w/ Leonardo Sibilio - Part 1 07.11.2023

In this captivating episode, we delve into the world of biotech scale-up with the seasoned expert, Leonardo Sibilio, CSO at BetaPro Consulting and CEO of the Biotech Academy in Rome. Discover how mastering the art of biotech scale-up can transform your journey from doubt to dominance. Key Takeaways: 1. Early Planning is Paramount: Leonardo emphasizes the importance of initiating the scale-up proce...

Biotech Simplified: Your Path to Bioprocess Mastery Unveiled (Trailer) 31.10.2023

Are you a busy biotech scientist, trying to navigate the complex world of bioprocessing while fueling your passion for science? Join us on the Smart Biotech Scientist Podcast, where we're about to unravel the secrets to bioprocess mastery. Hosted by a seasoned biotech leader and entrepreneur with over 15 years in the industry, this podcast is your compass through the maze of challenges. Pictu...

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