Plenary Session

ADAURA OS RESULTS - THE TRIAL WAS UNETHICAL 08.06.2023 24:07 ↓

Researchers were too busy counting dead bodies to give the control arm appropriate therapy when their cancer recurred. Disgusting conduct. I break down ADAURA

OBS studies vs RCTs - Trial Emulation - RCT Duplicate - We debate recent JAMA Paper 17.05.2023 1:15:06 ↓

Mike Putman, Todd C. Lee, John Mandrola and I debate the recent JAMA paper on RCT Duplicate. This is a spirited round table discussion on the limitations of observational data. If you are reading this, leave a comment as a review!

Myeloma Roundtable - Manni M. Raj C. VP discuss controversies 13.05.2023 1:20:55 ↓

Early treatment of myeloma, dual vs. single maintenance, and finally transplant or no transplant.

Mammographic Screening : A complete review of the evidence 11.05.2023 37:04 ↓

Why the USPSTF is wrong

The Crushing, Cruel Cost of Cancer Drugs - My Lecture 29.04.2023 30:37 ↓

Cost of Cancer drugs - VP's lecture

Sensible Med Crossover - Cifu/ Mandrola/ Prasad & Wallensky 24.04.2023 1:23:39 ↓

I combine two latest tracks on interpreting medical studies, medical boards, 7 doses of vaccine, and finally Walensky. Stay tuned.

Cochrane Mask Debates - Jefferson/ Heneghan/ Prasad 15.04.2023 1:17:52 ↓

We explore the fight btw NYTimes, Cochrane, and the last people keeping EBM alive

Zeb Jamrozik - Vaccine errors/ Sweden/ Equipoise & Science itself 12.04.2023 1:13:04 ↓

Zeb joins me for the 7th time to discuss all the key pandemic questions

Harvard-MIT Center for Reg. Science Lecture (4-4-23) - Dubious FDA drug Approvals 05.04.2023 57:38 ↓

My lecture to Harvard regulatory science

5.47 - Real World Evidence - Keynote Lecture in Denmark 26.03.2023 48:52 ↓

VP goes to Denmark to give the keynote at the Danish medical association conference

5.46 - What is Science: reflections on the field 10.03.2023 29:40 ↓

What is science?

5.45 - Bar Karmma - Karmma 3 | Idacel vs 'standard care 07.03.2023 1:52:18 ↓

Karmma 3 discussion; then Sensible Medicine on Long COVID, 4th year fellowships and more; Then my breakdown of FDA's NEJM Letter to the Editor

More basics on randomized controlled trials - Part 2 02.03.2023 42:41 ↓

I get into endpoints, surrogates, validation, blinding, crossover, and control arms.

RCT 101 And Papa Heme 28.02.2023 1:10:25 ↓

I talk RCTs 101; KM Plots; Blinding: 2:1 randomization: Concealment and more. Then Papa Heme Tells you How to Find your First Job

Tom Newman And VP Discuss Public Health 22.02.2023 56:48 ↓

Dr. Tom Newman UCSF Emeritus Professor & Superb teacher discusses VP's recent Public Health Videos. The two don't fully agree, but the discussion is worth your time.

5.41 - Michael Putman MCW debates me on recent policy Qs 16.02.2023 1:07:24 ↓

Mike Putman, asst prof. EBM Rhematologist debates me on value of boosters, observational studies and more.

Sensible Med Superbowl Plenary Session Crossover 13.02.2023 53:41 ↓

A new podcast feed called Sensible Medicine is up; here is a sample of what we have to offer

5.39 - Sotorasib and Codebreak 200 10.02.2023 44:56 ↓

I destroy the trial. Bad control arm. Informative Censoring. No OS gain. Authors DOWNPOWERED TRIAL. Fishy PFS. Fishy HRQoL. This trial should be in trash can.

Myeloma Twitter Just Makes Things Up - Lessons for All Oncologists & Expertise 22.01.2023 42:08 ↓

I annotate an online case discussion; Every decision is not based in evidence. Madness

5.37 - Keynote Lecture on Physician Burnout 15.01.2023 40:10 ↓

This lecture on Burnout will not be like any other you have heard

5.36 - ASH UPDATE #4 - GEM CESAR 30.12.2022 22:02 ↓

I break down the GEM CESAR trial K, R, D, Pom, Dara, Dex, R, and Auto and all before you actually have cancer What a crazy trial!

5.35 - ASH Update #3 - the Ascent Trial 29.12.2022 19:14 ↓

This uncontrolled trial of Dara-KRD claims to be looking for cure; Unfortunately, the PI has not thought through what that would look like, and accordingly all the claims are incorrect. Moreover the primary endpt is negative. Sad day for oncology

5.34 - ASH Update #2 - ALPINE - Zanibrutinib vs Ibrutinib - Deconstructed 24.12.2022 21:37 ↓

Sample size games, primary endpoint, head to head trials in oncology Rate this podcast on itunes Coming next is Triangle trial

5.33 USC Grand Rounds Hematology 23.12.2022 47:59 ↓

Grand rounds on heme and heme malignancies given 12/16 at University of Southern California (some parts removed) More ASH coming soon

5.32 - ASH Update #1 - Talquetamab NEJM 11.12.2022 17:48 ↓

Is it acceptable to take someone with myeloma who has gotten just 2 regimens and put them on a phase 1? VP says hell no.