Plain English with Derek Thompson

Today, we are witnessing an unprecedented assault on American science. Thousands of workers have been dismissed from the National Institutes of Health and the National Science Foundation. Billions of dollars are being cut from the NIH and NSF. Talented scientists are leaving the field (or leaving the country). Clinical trials and longitudinal studies are ending without explanation. Major research...

In the last few weeks, for the first time in my life, I’ve seriously thought about the 21st century not being another American century. A recent essay in the journal Foreign Affairs by Rush Doshi and Kurt Campbell put things as starkly as I’ve ever seen. Some people are still stuck in a mode of thinking about China as being a place that just makes things of little value and significance. But Made...

In 1937, a Rhode Island psychiatrist named Charles Bradley ran an experiment on 30 child patients who had complained of headaches. He gave them an amphetamine, that is a stimulant, called Benzedrine, which was popular at the time among jazz musicians and college students. The experiment failed, in one sense. The headaches persisted. But he noted that half of the children responded in what he calle...

Last week, a team of astrophysicists from the University of Cambridge announced that they had discovered the “strongest indication” ever of extraterrestrial life. The source did not come from Mars or Venus or any nearby moon. It came from K2-18b, a massive planet some 120 light-years from Earth. If this finding checks out, it is, without question, one of the most important discoveries in the histo...

In the past three weeks, we've spoken to economists about the tariffs. We’ve spoken to a historian about the Smoot-Hawley Tariff Act and the 100-year legacy of American protectionism. We've spoken to supply chain expert Jason Miller from Michigan State about why China is set up to win the upcoming trade war. But the voice we haven’t heard is the voice of business. People who run companies are scre...

The U.S. is in the opening innings of a full-blown trade war with China. What does that actually mean? What do we sell to China? What does China sell to us? How is each country dependent on the other for the supply of electronics, food, machines, and goods? Jason Miller, a professor at Michigan State and an expert on global supply chains, tells Derek that in the trade war between the U.S. and Chin...

The 1920s and the 2020s share a special kinship. One hundred years ago, the U.S. was grappling with a mix of growth, technological splendor, and generational anxiety—a familiar cocktail (albeit, from an era where cocktails were illegal). The era’s young people felt uniquely besieged by global forces. “My whole generation is restless," F. Scott Fitzgerald wrote in This Side of Paradise. “A new gene...

Donald Trump's tariff plan has set global markets on fire. What are they for? What are they trying to accomplish? Fresh off his black-out-rage session on CNBC, Derek talks to Matthew Klein, the author of ‘The Overshoot’ newsletter and coauthor with economist Michael Pettis of the widely acclaimed economics book ‘Trade Wars Are Class Wars.’ We talk about the Trump tariffs, their place in history, t...

Donald Trump's second term has been a breakneck whirlwind: tariffs announced, tariffs unannounced, tariffs reannounced, allies threatened, and global coalitions ripped apart. What sort of a world are Trump and the White House trying to build? If you stand back from the brush strokes, and take in the full mural, it is possible to see something like a grand economic strategy. One way his chief econo...

Corruption. Class wars. Technological splendor. The dawn of a new age of business and government. Rockefeller and Carnegie. The Gilded Age in America—roughly the 1870s through the early 1900s—was one of the most fascinating and misunderstood eras in our history. It seems like every week, news organizations claim that the U.S. is in a new Gilded Age. But what does that mean? What was the Gilded Age...

Donald Trump is serving up a scarcity agenda to America. He and the White House say we don’t have an economy that works, so we might just need to accept a period of economic hardship. They say America cannot afford its debt, and therefore we cannot afford health care for the poor. They say America doesn’t have enough manufacturing, so we have to accept less trade. They say America doesn’t have eno...

Generation Z, which was born between the late 1990s and the early 2010s, has a unique economic, political, and cultural identity. In the 2024 election, Gen Z shifted strongly to the right. They are less likely than any previous generation to expect they’ll achieve the American Dream. Most of Gen Z graduated into a pandemic economy or entered high school during the school shutdown years. They have...

Cancer is not a singular disease but a category of hundreds, even thousands, of rare diseases with different molecular signatures and genetic roots. Cancer scientists are looking for a thousand perfect keys to pick a thousand stubborn locks. Today's episode is about the hardest lock of them all: pancreatic cancer. Cancer’s power lives in its camouflage. The immune system is often compared to a mil...

Artificial intelligence tools for musicians are getting eerily good, very fast. Their work can be maddening, funny, ethically dubious, and downright fascinating all at the same time. TV and podcast composer Mark Henry Phillips joins to describe his experience working with them. We talk about the job of modern music composition; why he's worried AI might eventually do much of his current job; the m...

Something alarming is happening with reading in America. Leisure reading by some accounts has declined by about 50 percent this century. Literacy scores are declining for fourth and eighth graders at alarming rates. And even college students today are complaining to teachers that they can’t read entire books. The book itself, that ancient piece of technology for storing ideas passed down across de...

If you had to describe the U.S. economy at the moment, I think you could do worse than the word stuck. The labor market is stuck. The low unemployment rate disguises how surprisingly hard it is to find a job today. The hiring rate has declined consistently since 2022, and it's now closer to its lowest level of the 21st century than the highest. We’re in this weird moment where it feels like everyb...

Who is the most successful president in American history? George Washington secured American independence. Abraham Lincoln preserved the union and ended slavery. Franklin D. Roosevelt ended the Depression, remade government, and won World War II. But if we define "success" as the ability to articulate your goals and achieve every single one of them, perhaps only one president in American history w...

For the past month, chaos and confusion have gripped Washington and the federal government. Elon Musk and his Department of Government Efficiency, or DOGE, have served as an iron fist of the Trump administration—ransacking government agencies, lighting fires in various departments, and generally firing as many people as they can get away with. Much of this work is plainly illegal. Every 12 hours,...

This is a conversation I've wanted to have for a long time. It's about the decline of religion in America, the value of faith, the case for belief, and the rational reasons to believe in God. My guest is the New York Times columnist Ross Douthat. He is a Catholic conservative. From an identity checkbox standpoint, we are very different people. But Ross is one of my favorite writers from any point...

Why is it so hard to find a cure for Alzheimer’s? A simple answer is that the brain and its disorders are complicated. But as today’s guest, Charles Piller, writes, there’s another, more sinister factor at play. His new book, 'Doctored,' traces an incredible, true story of fraud, arrogance, and tragedy in the quest to cure Alzheimer’s. In the last few years, some of the most famous and revered neu...

Fans of green energy like me face some inconvenient truths about the global energy picture. First, coal sounds like a dirty technology that the rich world is moving on from. But nearly 9 billion tons of coal were burned last year—an all-time high. Second, "peak oil" is a prediction that many analysts have thrown around in the past few years, but oil production is also near its all-time high. Third...

Wealth isn’t just about financial security, according to today’s guest, Sahil Bloom. It’s about time wealth (the freedom to control our own schedules), social wealth (deep relationships with family and friends), mental wealth (the space to think clearly about the most important questions in life), and physical wealth (health and vitality). Bloom’s new book, 'The 5 Types of Wealth,' is uncommonly w...

In the past few years, we've learned that GLP-1 drugs don’t just help with diabetes or increase people’s feelings of fullness to help them lose weight. They have broad effects on substance abuse and behavior. They even seem to help with otherwise incurable illnesses, like Alzheimer's and schizophrenia. This month, a team of scientists studying 2 million patients in the Veterans Affairs medical sys...

Today, tech talk with an old friend of the pod, Kevin Roose of The New York Times, who is also host of the 'Hard Fork' podcast. This is a show about everything. And it’s going to remain a show about everything because I’m a little bit interested in everything. But one cost of that purposeful lack of narrow focus is that sometimes you fail to communicate the gravity of the important things that are...

This is the first episode of a little experiment we’re trying this year, a podcast within a podcast on history that we’re calling, simply enough, 'Plain History.' There are, I am well aware, a great number of history podcasts out there. But one thing I want to do with this show is to pay special attention to how the past worked. In this episode, for example, we're using the assassination of an Ame...