NutraSift: The nutraceutical innovation podcast

Bacosides increase dendritic branching length and dendritic intersection points in hippocampal neurons. This isn't a chemical effect that wears off, it's structural neuroplasticity. But it takes 8-12 weeks of continuous use to manifest, which is why most short-term studies show nothing and most consumers give up before the mechanism kicks in. Bacopa's "failure" in the market...

30mg/day of saffron extract showed comparable efficacy to fluoxetine (Prozac) and imipramine in multiple randomized, double-blind clinical trials for mild-to-moderate depression. A $10,000/kg spice, at 30mg per dose, costs ~$0.30/dose and matched a blockbuster pharmaceutical. The evidence quality is remarkably high relative to the number of studies. Publications of interest: https://pubmed.ncbi.nl...

Fresh ginger is rich in 6-gingerol. Drying converts gingerols to shogaols. 6-Shogaol is 2-3x more potent than 6-gingerol for anti-inflammatory activity and activates TRPV1 (pain receptor). This means dried ginger extract is pharmacologically different from fresh ginger extract. The processing method creates a different medicine. Most product labels don't distinguish between the two. Publicatio...