Mind & Matter

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Wide release date: July 23, 2025 Episode Summary: Dr. Timothy Ryan talks about the high energy costs of synapses, the role of mitochondria and glycolysis, and challenge the long-held view that the brain relies solely on glucose by discussing new evidence that neurons burn fats from lipid droplets for fuel, esp...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Wide release date: July 18, 2025 Episode Summary: Dr. Eugene Chang talks about the microbiome’s role as a vital organ, the impacts of antibiotics and Western diets on microbial health, and strategies for restoring a damaged microbiome through diet and fecal microbial transplants. They delve into microbiome dys...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Wide release date: July 13, 2025 Episode Summary: Dr. Ying-Hui Fu discusses her research on the genetics of sleep, focusing on natural short sleepers who thrive on 4-6 hours of sleep and the heritability of sleep traits like duration and timing. She explores how sleep efficiency, rather than just duration, may...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Wide release date: July 8, 2025 Episode Summary: Dr. Charles Cornish-Dale discusses the decline of masculinity in modern society, linking it to falling testosterone levels, environmental endocrine disruptors, and the limitations of liberal democracy. Drawing on Francis Fukuyama’s “End of History & the Last Men...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Wide release date: July 4, 2025 Episode Summary: Dr. Joseph Takahashi discusses circadian rhythms, exploring their biological basis, from molecular mechanisms to their impact on metabolism and health; the discovery of circadian clock genes; role of the suprachiasmatic nucleus, and how light, feeding, and oxyge...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Wide release date: June 29, 2025 Episode Summary: Cell Biologist Dr. Bill Bement explains the dynamic world of the cell cortex, discussing how actin filaments and microtubules drive processes like cell division and wound healing through self-assembly and self-organization; energy dynamics of these processes; t...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Wide release date: June 25, 2025 Episode Summary: Dr. Marius Pachitariu discusses how the brain computes information across scales, from single neurons to complex networks, using mice to study visual learning. He explains the differences between supervised and unsupervised learning, the brain’s high-dimensiona...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Wide release date: June 16, 2025 Episode Summary: Dr. Steven Laviolette discusses the role of lipids, particularly endocannabinoids and fatty acids, in brain signaling and mental health, discussing how dietary omega-3 and omega-6 imbalances, prenatal THC exposure, and fatty acid binding proteins (FABPs) impact...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Wide release date: June 11, 2025 Episode Summary: Dr. Brian Kerley talks about the health impacts of seed oils, their high omega-6 fatty acid content, and their role in chronic diseases through mechanisms like lipid peroxidation and oxidative stress. They explore how these industrially processed oils may contr...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Wide release date: June 5, 2025 Episode Summary: Dr. David Healy critiques modern medicine, focusing on SSRIs and psychiatric medicine, including: how pharmaceutical companies manipulate clinical trial data, ghostwrite studies, and influence medical practice, often ignoring patient experiences; highlighting is...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Wide release date: May 25, 2025 Episode Summary: CaaMTech CEO Dr. Andrew Chadeayne, discusses the chemistry of magic mushrooms and other psychedelics, their potential therapeutic applications, and the challenges of commercializing them in a shifting biotech market. The conversation delves into the complexities...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Wide release date: May 15, 2025 Episode Summary: New research on how dietary fats, particularly omega-6 fatty acids like linoleic acid, influence triple-negative breast cancer progression by activating the mTOR pathway, a key regulator of cell growth. They explore the role of the FABP5 protein in enhancing can...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Wide release date: May 10, 2025 Episode Summary: Dr. Gyorgy Buzsaki discusses the hippocampus’s role beyond memory and spatial navigation, delving into its broader functions in cognition, action planning, and brain-body interactions; how hippocampal rhythms, like sharp wave ripples, influence memory consolidat...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Episode Summary: Dr. Nirosha Murugan discusses the role of biophysics in biology, focusing on how light, particularly biophotons emitted by cells, influences processes like wound healing, neural activity, and cancer detection; how microtubules may act as biological fiber optics, the impact of modern light envi...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Episode Summary: Dr. Alex Kwan discusses how psychedelics like ketamine and psilocybin induce rapid neuroplastic changes in the brain, particularly in the prefrontal cortex, contrasting their effects with traditional antidepressants like SSRIs, and exploring their potential for treating depression and chronic...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Short Summary: The flaws of nutrition epidemiology with Dr. John Speakman About the guest: John Speakman, PhD is a professor at the University of Aberdeen and runs a lab in Shenzhen, China, focusing on energy balance, obesity, and aging. Note: Podcast episodes are fully available to paid subscribers on the M&M...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Short Summary: Cancer’s metabolic roots with Dr. Thomas Seyfried. About the guest: Thomas Seyfried, PhD is a professor of biology at Boston College. He has researched cancer metabolism, epilepsy, and lipid biochemistry for over 40 years. Note: Podcast episodes are fully available to paid subscribers on the M&M...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Short Summary: Heart health and the ketogenic diet, with expert insights from a cardiologist and researcher. About the guest: Matthew Budoff, MD, is a preventive cardiologist and professor of medicine at UCLA School of Medicine. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Short Summary: The science of obesity and appetite regulation, blending genetics and neurobiology with practical insights About the guest: Giles Yeo, PhD is a professor of molecular neuroendocrinology at the University of Cambridge. He leads a lab studying obesity and appetite regulation. Note: Podcast episode...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Short Summary: A deep dive into the science of oxidative stress, antioxidants, aging, and neurodegenerative diseases like Alzheimer’s. About the guest: Pamela Maher, PhD is a professor at the Salk Institute in San Diego, California, with a focus on neurodegenerative diseases, oxidative stress, and antioxidants...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Short Summary: How environmental chemical exposures affect neurodegenerative disease and health. About the guest: Gary Miller, PhD is a Professor of Environmental Health Sciences at Columbia University. His research bridges pharmacology, toxicology, and neuroscience to explore neurodegeneration, particularly P...

Short Summary: How diet shapes the gut microbiome and impacts health, with microbiologist Dr. Peter Turnbaugh breaking down the complex science. About the guest: Peter Turnbaugh, PhD is a professor of microbiology and immunology at the University of California, San Francisco, where he leads a lab studying the gut microbiome’s role in nutrition and drug response. Note: Podcast episodes are fully av...

Short Summary: The science of diabetes with Dr. Scott Soleimanpour, blending personal insights and cutting-edge research that gets into mitochondrial biology and more. About the guest: Scott Soleimanpour, MD, is a physician-scientist at the University of Michigan’s Caswell Diabetes Institute, where he runs a lab studying pancreatic beta cell biology and mitochondrial quality control in diabetes. N...

Short Summary: An insider’s look at the messy realities of scientific research with Stanford’s Dr. John Ioannidis. The good, the bad, and the ugly about how scientific research actually works. About the guest: John Ioannidis, MD, PhD is a professor at Stanford University in medicine, epidemiology, population health, and biomedical data science, with an MD from the University of Athens and a PhD fr...

This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.com Short Summary: Personalized health monitoring with Professor Michael Snyder, blending cutting-edge science with practical tips and actionable insights. About the guest: Michael Snyder, PhD is a Professor of Genetics at Stanford University School of Medicine. He directs the Center for Genomics and Personalized...