Idea Machines

In this episode I talk to Adam Marblestone about technology roadmapping, scientific gems hidden in plain sight, and systematically exploring complex systems. Adam is currently a research scientist at Google DeepMind and in the past has been the chief strategy officer at a brain-computer interface company and did research on brain mapping with Ed Boyden and did his PhD with George Church. He has a...

In this episode I talk to Jude Gomilla about distributed innovation systems focused especially around the bottom-up response to the coronavirus crisis. Jude is a physicist, founder and CEO of the knowledge compilation platform Golden, and a prolific angel investor. He's also been in the thick of the distributed response to the coronavirus response from day one. Key Takeaways - There's a clear gap...

Intro In this episode I talk to Joel Chan about cross-disciplinary knowledge transfer, zettlekasten, and too many other things to enumerate. Joel is an a professor in the University of Maryland's College of Information Studies and a member of their Human-Computer Interaction Lab . His research focuses on understanding and creating generalizable configurations of people, computing, and information...

In this episode I talk to Anna Goldstein about how the ARPA ( A dvanced R esearch P rojects A gency) model works and what makes it unique. We focus on ARPA-E : the department of Energy's version of DARPA that funds breakthrough energy research. Anna is a Senior Research Fellow at the University of Massachusetts Amherst and the author of the paper " Funding Breakthrough Research " that systematical...

In this episode I talk to Jason Crawford about his work on the history of progress, funding and incentivizing inventions, ideas behind their time, and more. Jason is the author of the Roots of Progress blog , where he focuses on telling the story of human progress in an amazingly accessible way.  Key Takeaways Funding *structures* are understudied as a progress-enabling mechanism *Why* inventions...

In this episode I talk to Eli Velasquez about creating startup ecosystems, commercializing research, especially when it's not necessarily venture-backable, and how the US government thinks about startups. Eli is the head of Venture Development at VentureWell - a non profit organization that funds and trains faculty and student innovators to create businesses. VentureWell helps run I-corps, which t...

In this episode I talk to Bill Janeway about previous eras of venture capital and startups, how bubbles drive innovation, the role of government in innovation. Bill describes himself as "theorist-practitioner": he did a PhD in Economics, was a successful venture capitalist in the 80's and 90's with the firm Warburg Pincus and is now an affiliated faculty member at Cambridge and the member of sever...

In this episode I talk to Mark Hammond about how Deep Science Ventures works, why the linear commercialization model leaves a lot on the table, and the idea of venture-focused research. Mark is the founder of Deep Science Ventures, an organization with a fascinating model for launching science-based companies. Mark has many crisply articulated theses about holes in the current system by which rese...

Alexey Guzey is an independent researcher focusing on how to systemically increase the rate of biology discoveries and the idea that reviving the patronage system may be a way to do that. We spend most of our time talking about the project he's been working on for the past year but also touch on some of his thinking around connecting with people, which he's written about extensively.  Key Takeaway...

Cindy Wu and Denny Luan are the founders of experiment.com - a platform that allows anybody to request funding for a science project and anybody to fund them. It's fascinating because it stands completely outside of the grant funding and publication system that drives most science today. In this podcast we discuss how the current system prevents the creating of new fields, why science communicatio...

In this episode I talk to Errol Arkilic about different systems involved in turning research into companies. Errol has been helping research make the jump from the lab to the market for more than fifteen years: he was a program manager at the National Science Foundation or NSF, Small Business Innovation Research or SBIR program , where he awarded grants to hundreds of companies commercializing res...

In this conversation Sam Arbesman and I talk about unlocking cross-disciplinary innovations, long term organizations, combinatorial creativity and much more. As you might expect from someone with Generalist Thinking as a main area of interest, Sam has out-of-the-box insights in a ton of domains and he's amazing at capturing them in tight concepts like "knowledge mining" and "jargon barriers." By d...

In this episode I speak to Matt Clifford about talent investing, how big long term projects can start small, and financial innovations. Matt is the CEO and co-founder of Entrepreneur First. Entrepreneur First, abbreviated as EF, is a fascinating system. It starts with cohorts of around fifty to a hundred ambitious, talented people who want to start companies but might not even have an idea to buil...

In this episode I talk to Evan Miyazono about tackling metaresearch questions, how novel physical phenomena go from "oh that's cool" to devices that harness cutting edge physics, and how we could better incentivize the creators of innovations where traditionally it's hard to capture value, like open-source software and early-stage research. Evan is a research scientist at Protocol Labs where he he...

In this episode I talk to William Gunn about the guts of science publishing, changing incentives in science, and the relationship between publishing and funding. William is currently the Director of Scholarly Communication at Elsevier. He joined Elsevier when they acquired Mendeley, which is a platform designed to help researchers share papers and notes about them. Before that he was an academic r...

In this episode I talk to Torben Nielsen about creating new products and systems in health insurance. We touch on the tension between insurer's well-founded risk aversion and trying new things, the process of insurance companies working with startups, and how to even know if things are working. Torben runs programs at Premera Blue Cross with both internal teams and external startups to build new p...

In this episode I talk to Dr Robert McNutt about medical innovation, medical research and publishing, and patient choice. Robert has been practicing medicine for decades and has published many dozens of medical research papers. He is a former editor of JAMA - the Journal of the American Medical Association. He's created pain care simulation programs, run hospitals, sat on the national board of med...

In this episode I talk to Craig Montouri about nonprofits and politics. Specifically their constraints and possibilities for enabling innovations. Craig is the executive director at Global EIR - a nonprofit focused on connecting non-U.S. founders with universities so that they can get the visas they need to build their companies in America. Craig's perspective is fascinating because contrary to th...

Overcast Link.   My Guest this week is Mason Peck, Professor of Aerospace and Systems engineering at Cornell University and former Chief Technologist at NASA. Previously Mason was a was a Principal Fellow at Honeywell Aerospace and has an extremely colorful history we get into during the podcast. The topic of this conversation is how NASA works, alternatives to the current innovation ecosystem - l...

In this episode I talk to Gary Bradski about the creation of OpenCV, Willow Garage, and how to get around institutional roadblocks. Gary is perhaps best known as the creator of OpenCV - an open source tool that has touched almost every application that involves computer vision - from cat-identifying AI, to strawberry-picking robots, to augmented reality. Gary has been part of Intel Research, Stanf...

Link to this Episode in Overcast In this episode I talk to Jun Axup about accelerating biotechnology, how to transition people and technology from academia to startups, the intersection of silicon valley and biology, and biology research in general. Jun is a partner at IndieBio - a startup accelerator specializing in quickly taking biotechnology from academic research to products. She has both sta...

My Guest this week is Adam Wiggins, the cofounder of Ink & Switch — an independent industrial research lab working on digital tools for creativity and productivity.   The topic of the conversation is the future of product-focused R&D, the Hollywood Model of work in tech, Ink & Switch's unique organizational structure, and whether it can be extended to other areas of research.   Links Adam Wiggins'...

My guest this week is Brian Nosek, co-Founder and the Executive Director of the Center for Open Science. Brian is also a professor in the Department of Psychology at the University of Virginia doing research on the gap between values and practices, such as when behavior is influenced by factors other than one's intentions and goals. The topic of this conversation is how incentives in academia lead...

My Guest this week is Malcolm Handley, General Partner and Founder of Strong Atomics. The topic of this conversation is Fusion power - how it's funded now, why we don't have it yet, and how he's working on making it a reality. We touch on funding long-term bets in general, incentives inside of venture capital, and more. Show Notes Strong Atomics Malcolm on Twitter (@malcolmredheron) Fusion Never P...

My guest this week is Mark Micire, group lead for the Intelligent Robotics Group at NASA's Ames Research Center. Previously Mark was a program manager at DARPA, an entrepreneur, and a volunteer firefighter. The topic of this conversation is how DARPA works and why it's effective at generating game-changing technologies, the Intelligent Robotics Group at NASA, and developing Robotics and technology...