Future Science Group

In this episode, supported by BioRad, we explore cell proliferation monitoring and its role in drug discovery, guided by the expert advice of Rachel Preston, Product Development researcher at Bio-Rad. We discuss techniques available to monitor cell proliferation, their advantages and disadvantages and the importance of selecting the right combination of techniques for different experimental target...

In this Tech Blast episode, is Jay Lemke, Senior Research Scientist at Promega, provides a brief overview of Sanger sequencing, its history, working principle and development over the last half century. Jay reveals which lab practices are still are best completed with Sanger sequencing and explains why the technique remains so prevalent today, even in the era of next-generation sequencing. Get Jay...

Find out about current treatment options for thyroid cancer such as the recent approval of selpercatinib for patients with an alteration in the RET gene in this interview with Kate Newbold who is a clinical oncologist consultant at The Royal Marsden Hospital in London (UK).

In this episode, we explore the field of synthetic biology. Discover the history of the field and its origins in the production of biofuels, before fracking burst onto the scene forcing a pivot in direction towards chemical production. Find out about the key techniques that have brought synthetic biology into the realm of immunotherapies and cancer research, which have even welcomed in a return to...

In this Tech Blast episode, Tim Bolus, Compliance Program Manager at Molecular Devices, provides a 15-minute in-depth exploration of the regulatory landscape of drug discovery and development. Tim examines the good lab and manufacturing processes essential to successful drug discovery, development and production. Get Tim's insight into the field and discover how to best prepare your lab to pass th...

We are talking all things DNA methylation in this episode, providing a brief explanation of epigenetics and the technologies involved in the study of DNA methylation, before exploring the application of these techniques in the study of infectious diseases and cancer. Revealing all of this information is my guest Chloé Goldsmith, Postdoctoral Research Fellow at Canberra University, whose research f...

In this episode, supported by Roche, we explore a vital aspect of many next-generation sequencing studies: target enrichment. Here, regions of interest are selectively amplified before sequencing takes place. More specifically we examine some of the new technologies improving this key step and their impact on oncology research. My guest for this episode is Brian Godwin, Director of Reagent and Ass...

In this episode, we roam the world of recombinant proteins and their production, discussing the challenges of their production, and recent evolutions in protein engineering that have brought the field into a golden era of innovation. I'm joined by recombinant protein engineering expert Yuning Chen, R&D Manager at Sino Biological, who discusses the key applications of recombinant proteins, the...

Analysis of nitrosamine impurities: an interview with Javier Jimenez-Villarin by Taylor & Francis Group

PCR has evolved rapidly over the last few years, an evolution that has been dramatically accelerated by the COVID-19 pandemic. New technologies and approaches have been brought to the fore and the full range of applications for which this technique can be applied have been highlighted, from diagnostics to basic disease research and immunology. This episode explores this evolution, looking at how c...

Data Completeness: a podcast with Dan Drozd by Taylor & Francis Group

Love it or hate it, western blotting forms the bedrock of countless studies across numerous disciplines. Explore its history, development and applications in this episode all about the marmite of life science techniques. Guiding me through the hand wringing, hair follicle destroying history and process of western blotting, and hopefully explaining the beauty and potential of the technique - is Ken...

Immunoassay applications: a podcast with John Chappell by Taylor & Francis Group

Uncover the history of molecular therapeutics, the staggering current applications and developments of these therapeutics and what their future could hold, in this episode of Talking Techniques. To explore the field of molecular therapeutics and provide an insight into their production, is Aaron Clauson, Product Manager at Zymo research. First, we cover the ins and outs of targeting the therapies...

This episode centers on the critical role that high-performance liquid chromatography (HPLC) plays in the production of adeno-associated viral (AAV) therapies, the latest advances in AAV design and the next steps in their development. Filling me in on all things HPLC and AAVs is Bella Neufeld, Director of R&D at Teknova. Bella reveals the essential validation and quality control steps required...

As the transition from 2D to 3D cell cultures, or organoids, as the gold standard for modeling basic biology and disease continues, these models are being utilized in ever more intricate and impactful ways. This episode covers the rise of organoids and their advantages over 2D cell cultures, before exploring just how representative these models are becoming and their new applications in drug disco...

Automation of ADME: a podcast with Prakash Bhosale by Taylor & Francis Group

In this podcast interview, Jason Evans (Scientist at Q² Solutions; NY, USA) discusses the importance of automation and key advantages of taking an assay from the bench to an automated platform. He also explains the increase in throughput when his lab transitioned to automated assays and the hurdles he faced when automating assays.

Welcome to part 2 of this two-part episode on whole-genome sequencing (WGS) in rare disease research and treatment. In part one we discussed the impacts the technology has had on both improving the clinical diagnosis and management of rare diseases and on drug development and basic research studies.  This episode goes beyond the technology's capabilities and into the debates surrounding how,...

Love it or hate it, western blotting forms the bedrock of countless studies across numerous disciplines. Explore its history, development and applications in this episode all about the marmite of life science techniques. Guiding me through the hand wringing, hair follicle destroying history and process of western blotting, and hopefully explaining the beauty and potential of the technique - is Ken...

In this episode, we take a look at one of the key steps of infectious disease research, sample collection; exploring the challenges associated with the step and the solutions available to improve infectious disease research around the globe. Exploring the trials and tribulations of infectious disease sample collection with me is Stanislav Forman, Product Developer at Zymo Research (CA, USA). Stan...

Explore the realm of epigenetics and gene expression, discovering the different omic ‘lenses’ used to examine these processes and the power of single-cell studies to reveal provide a comprehensive multiomic view of cells and their biology.   This episode features the ever-buoyant Will Greenleaf, Associate Professor of Genetics at Stanford University School of Medicine (CA, USA) and head...

Cryopreservation of advanced therapy medicinal products: an interview with Brian Hawkins by Taylor & Francis Group

This episode, supported by Bethyl, delves into the realm of the tumor microenvironment (TME), exploring the cells that reside there and how they interact to promote tumor growth and metastasis. Discover how immune cells are attracted and manipulated by tumor cells enabling the cancer to invade neurons where they can then travel throughout the body. Providing an expert's insight into this topic is...

Rare diseases present a series of challenges on numerous fronts. From simply deciphering what a patient is affected by to considering how best to manage a rare condition with limited pre-existing medications available for a rare disease, each new development or breakthrough brings clinicians to a new question. While these conditions are, in isolation, rare; in total rare diseases impact 25-30milli...