Evolution

Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. New methods and multi-disciplinary collaborations are providing exciting new insights into the complicated evolutionary journey that gave rise to our species. However, we remain far from understanding some of the most striking human-specific char...

For the past 30 years, the frontiers of language science have been in the areas of neurolinguistics and genetics, both of which arose in conjunction with new technologies emerging in the 1990s. It is probably safe to say that these trends will continue apace as technology in these areas continues to advance, allowing for increasingly sophisticated and fine-grained analysis. From its inception, the...

Human cognition and behavior are highly heritable and so is liability to disorders that affect them. This includes neuropsychiatric disorders such as schizophrenia and autism spectrum disorder (ASD). We have started to integrate genetic risk data with the emerging maps of gene regulation to study human specific aspects of gene expression and gene regulation. These analyses indicate that human spec...

Africa is thought to be the ancestral homeland of all modern human populations within the past 300,000 years. It is also a region of tremendous cultural, linguistic, climatic, and genetic diversity. Despite the important role that African populations have played in human history, they remain one of the most underrepresented groups in human genomics studies. A comprehensive knowledge of patterns of...

The first Neandertal DNA was recovered 25 years ago, and since then, ancient DNA has provided many surprising insights into human evolutionary history. Among these are the discoveries of the multiple admixture events among late Pleistocene humans and the remnants of archaic DNA in our own genomes. How does ancient DNA research contribute to the future of anthropogeny? In this talk, I will reflect...

Our species is between 300,000 and 200,000 years old. For most of this one-quarter of a million years, up until just 12,000 years ago, it appears that our ancestors lived in small populations, in small-scale societies of which we can only guess the real nature. We remain in the dark about the age of some of the most diagnostic features of our species: our striding bipedalism, complex tool manufact...

The discovery and resolution of genetic variation is critical to understanding disease and evolution. Our most recent work sequences diverse human and nonhuman primate genomes using both ultra-long and high-fidelity long-read sequencing technologies. Advances in this area have made possible the first telomere-to-telomere assemblies of the human genome and much more complete chimp, gorilla and oran...

Neuroscience has made great strides in the last decade following the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative, a science and engineering grand challenge that has greatly accelerated research on large-scale recordings from neurons and reconstructions of neural circuits. Large-scale neural network models have in turn inspired major advances in artificial intel...

The human brain has a larger mass with respect to body weight, increased cortical neurons with respect to size, an expanded proliferative zone, and unique connectivity patterns. Human-specific neurodevelopment is not only marked by physical differences, but also by temporal changes. Human neurons, during both prenatal neurodevelopment and adult neurogenesis, exhibit an exceptionally delayed time c...

As humans have evolved, so has our ability to drastically alter the planet we call home. In this collection of talks from the CARTA symposium, "Humans: The Planet-Altering Apes" you will learn about specific examples on how humans have changed Earth and what can be done to prevent its cataclysmic demise. David Holway addresses the challenges of emerging invasive species in our ecosystem. Oliver Ry...

As humans have evolved, so has our ability to drastically alter the planet we call home. In this collection of talks from the CARTA symposium, "Humans: The Planet-Altering Apes" you will learn about specific examples on how humans have changed Earth and what can be done to prevent its cataclysmic demise. Rob Knight will talk about how all microbiomes that have been studies are impacted by human ac...

As humans have evolved, so has our ability to drastically alter the planet we call home. In this collection of talks from the CARTA symposium, "Humans: The Planet-Altering Apes" you will learn about specific examples on how humans have changed Earth and what can be done to prevent its cataclysmic demise. Walter Willett will discuss how climate change is having devastating effects that will undermi...

This CARTA public symposia addresses specific examples of how humans have drastically altered the planet. Acknowledged experts discuss clearly defined global-scale negative impacts on planet earth, our life support system (other than climate change, population growth and infectious diseases, which are well-known). Each talk succinctly describes a specific impact, the role that our species has play...

Why does history keep repeating itself? And what can cats tell us about this? Ashley Poust, Ph. D., is a paleontology researcher at the San Diego Natural History Museum. He focuses on vertebrates and evolutionary biology and explains how the study of extinct cats, like the sabertooth, can help us reconstruct ancient environments, gain a better understanding of our origins, see deeper into life's p...

Through the Earth Microbiome Program and complementary efforts, we have sampled a broad range of microbiomes from across the planet. All microbiomes that have been studied are impacted by human activity — the effects of industrialization on the human microbiome are best characterized, but capture of animals in zoos, domestication, modification of soils through agricultural practices, and modificat...

In 1957, the USSR launched Sputnik 1, the first human object to leave Earth. In the 65 years since then the region of Earth orbit has become filled with satellites and space junk. The proliferation of debris has led to the prediction of Kessler Syndrome, a state where a never-ending cascade of collisions between orbital objects renders parts of space unusable for human purposes. However, there are...

We are experiencing an accelerated rate of loss of species due to human activities. This anthropogenic phenomenon extends beyond extinction. It encompasses an expanded loss of biodiversity as the genetic diversity of species diminish, reducing gene pools to “gene puddles.” We know details of species extinctions events from the fossil record, historical record, and from ancient DNA studies, and tha...

Humans now annually add more biologically available nitrogen to the Earth’s land surfaces than do all natural processes. For 3 billion years, available nitrogen had been the major limiting currency for life on Earth. The recent human disruption of the global nitrogen cycle is causing major environmental harm, including water and air pollution, marine dead zones, 10% of global greenhouse gas emissi...

Amazing new technologies in developmental biology and genetics research are allowing scientists to begin to answer long standing questions such as – how does a single fertilized egg cell transform into a complex animal? Why does the embryo of a marine organism like a sea slug develop differently from that of a sea urchin? Join Scripps Developmental Biologist Deirdre Lyons as she describes how she...

We are losing species much more rapidly now than in the last two million years! At this pace, we may lose a large proportion of vertebrates, including mammals, birds, reptiles, amphibians, and fishes, in the next two to three decades. Modern extinctions caused by human activities are higher than the normal or natural extinction rate which tells us that we may be causing a mass extinction. In the h...

This CARTA public symposia addresses specific examples of how humans have drastically altered the planet. Acknowledged experts will discuss clearly defined global-scale negative impacts on planet earth, our life support system (other than climate change, population growth and infectious diseases, which are well-known). Each talk succinctly describes a specific impact, the role that our species has...

Beginning with Homo erectus at least a million years ago, hominins have used fire to engineer the world around them. The earliest uses of fire surely included cooking, changing the energy yields of foods. Such innovations altered the course of our evolution, facilitating the evolution of species that could adapt quickly using tools and social ingenuity. Within the last 200,000 years, hominins also...

The introduction of species into new environments has occurred throughout human history. While most introductions fail and most of those few that establish remain environmentally innocuous, a notable minority wildly proliferates in their new ranges. These invaders disrupt ecosystems and burden economies. Environmental impacts associated with invasions are hard to predict and vary in space and time...

Humans have adapted to meet their water needs across disparate environments over time using behavioral adaptations. Yet, as temperatures rise and freshwater sources become depleted, it is critical to understand 1) how populations modify their environments to meet their water needs, and 2) the consequences of these anthropogenic - or human caused changes - on the environment and further on human he...

Human-made chemicals with the unexpected ability to interfere with our body’s endocrine system have become prominent contaminants in daily life. Because the hormones produced by our endocrine system create complex signaling networks that control our growth, maturation, fertility, immunity, behavior, and sleep, these endocrine disrupting chemicals, or EDCs, can exert powerful biological effects. De...