EHA Unplugged

In the fifth episode of the Clinical Trial podcast series, Prof. Robert Hills discusses the documentation of clinical trials and how it represents a safeguard for the credibility of the trial. He points out the importance of finding a good balance between too many documents and not enough of them. In addition, he highlights the multitude of different groups working on a clinical trial, which ultim...

In the fifth and final episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker and guest experts Prof Raul Cordoba, Dr Ulrich Wedding, and Dr Dominique Bron discuss the ethical issues associated with treating hematological malignancies in older adults. They raise different points regarding treatment decisions made with (and not without) the patient and amongst other param...

In the fourth episode of the Clinical Trial podcasts, Dr. Eleftheria Hatzimichael gives us an overview of the sponsor's role and responsibilities in investigator-initiated clinical trials. The different meaning of "sponsor" and "funder", the importance for physicians to be involved in the design of clinical trials, the eight overarching responsibilities of the sponsor, are all key topics discussed...

In the fourth episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker and guest expert Prof Monica Engelhardt discuss how comprehensive geriatric assessment can guide treatment decisions and improve patient outcomes. Dr Engelhardt gives us an insight into her clinical practice and how elderly hematology patients are receptive - or not - to this testing. You will also lear...

In the third episode of the Clinical Trial podcasts, Prof. Martin Dreyling from the University of Munich makes several points about standards of care in clinical studies, also mentioned as GCPs (Good Clinical Practices). He gives us a historical perspective on the establishment of these standards 20 years ago, and how they need an update through what he calls a ‘reality check’. Prof. Dreyling is p...

In the third episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker and experts Prof Antonio Almeida, Prof Valentin Goede, and Dr Annamaria Brioli discuss the treatment of hematological malignancies in older adults, involving polypharmacy in most cases. They describe how patients commonly react to polypharmacy and how challenging it can be to have all the information abo...

In the second episode of the Clinical Trial podcasts, former EHA President Prof. John Gribben gives us an overview of the role(s) of CROs (Contract Research Organizations) in clinical investigation. He discusses how they can help, notably with the paper trails associated with clinical trials, and how they should be constructive partners in the process of clinical research. In this series of Clinic...

In the second episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker discusses with experts Prof Alessandra Tucci and Prof Sergio Storti the definition and importance of patient assessment (including frailty, comorbidity, and polypharmacy), in older adults with hematological conditions and how it can be used to determine the overall ‘fitness’ of a patient. They also disc...

In this podcast, the last of a series dedicated to Multiple Myeloma in underserved patient populations with, Prof Sonja Zweegman focuses on the challenges associated with MM treatment in older patients, namely the assessment of frailty and how to adapt treatment in this population. The podcast also addresses the specific characteristics of MM in the elderly, including the incidence of genetic muta...

In the first episode of the Clinical Trial podcasts, Amsterdam UMC researcher and author of “A Quick Guide on How to Conduct Medical Research” Dr. Marieke Ter Wee points out the importance of formulating a research question at the beginning of any clinical trial. What models are used to formulate the question and answer to it? She unravels the main parts of a research proposal that should be elabo...

In the Aging Patient: Dispelling Myths podcast series, Prof Raul Cordoba kicks off a series of podcasts that will offer you up-to-date information about hematology in older adults. For the first interview, he welcomes guest expert Dr Kristina Kirschner to discuss aging and clonal disease. You will learn how clonal hematopoiesis increases with advancing age and how the accumulation of some clonal m...

In the third episode of the Iron Deficiency podcast series, host Prof Gunnar Birgegård and guest expert Dr Noemi Roy review the many important functions iron plays in the body, providing the background for the high prevalence of iron deficiency in women, particularly in their fertile life and during pregnancies. They address different strategies of treatment, including IV, oral treatment, and nutr...

In the second episode of the EHA Diagnosing And Treating Iron Deficiency podcast series, host Prof Gunnar Birgegård and guest expert Prof Christopher Winearls highlight the high prevalence of iron deficiency anemia in patients with CKD, together with its association with poor long-term outcomes. They discuss the importance of monitoring iron on top of monitoring erythropoietin and treating the def...

In the first episode of the EHA Diagnosing And Treating Iron Deficiency podcast series, Prof Gunnar Birgegård and host expert Prof Antonio Almeida define what is iron deficiency and more precisely functional iron deficiency. They discuss the prevalence of anemia in cardiac failure patients and the relation between severity of the heart disease and incidence of iron deficiency. They also highlight...

In episode 9 of "EHA Unplugged", Prof. Shaun McCann describes the importance of general medical management in multiple myeloma (MM) patients and the application of the principles of treatment in different subpopulations of patients. He also explains how to diagnose MM and assess the response to treatment. What did you think of this podcast? Share your opinions with us in this short feedback survey...

This podcast, the second of a series dedicated to Multiple Myeloma in underserved populations, addresses clinical challenges in MM, with a focus on high-risk disease and cytogenetics. Prof Weisel describes the established genetic prognostic markers in MM, and the new abnormalities that are becoming important, besides the role and impact of Minimal Residual Disease (MRD) on risk status and classifi...

In episode 8 of "EHA Unplugged", Prof. Shaun McCann details the diagnostic and prognostic criteria of CLL and the correct diagnostic work-up. He also describes the increasing array of treatments available for CLL patients and outlines the role of allogeneic transplantation in this disease. What did you think of this podcast? Share your opinions with us in this short feedback survey. Provide Feedba...

In episode 7 of "EHA Unplugged", Prof. Shaun McCann describes the clinical and genetic features of chronic myeloid leukemia (CML), discusses the best therapeutic options, and characterizes the changes that occur in the natural history of the disease after the introduction of tyrosine-kinase inhibitors (TKIs). What did you think of this podcast? Share your opinions with us in this short feedback su...

This podcast series brings together people affected by SCD and specialist hematologists to shed light on this widely misunderstood condition, bringing the guidelines to life and helping healthcare professionals improve their practice by understanding the patient experience. In this closing discussion, Dr Jo Howard and Professor Léon Tshilolo reflect on what they have learned from their conversatio...

In this podcast, the first of a series dedicated to Multiple Myeloma in underserved patient populations, Prof Terpos illustrates the impact of renal disease on MM outcomes and how it should best be managed. Follow the podcast to learn about assessment and monitoring of renal function in MM patients, the available treatment options for this population, and the role and outcomes of kidney transplant...

This podcast series brings together people affected by SCD and specialist hematologists to shed light on this widely misunderstood condition, bringing the guidelines to life and helping healthcare professionals improve their practice by understanding the patient experience. In the second episode, a mother and daughter affected by sickle cell are joined by hematologist Professor Léon Tshilolo for a...

In this podcast, Dr. Rijneveld discusses BCR-ABL1-like acute lymphoblastic leukemia (ALL), a specific subgroup of ALL characterized by an expression profile similar to Ph+ ALL, albeit lacking the BCR-ABL1 rearrangement, and by sensitivity to TKIs. She highlights how TKIs were game-changing for the prognostic of these patients, although their cost and associated toxicities (usually low but fatiguin...

Listen to this expert interview to discover characteristics and outcomes of acute lymphoblastic leukemia (ALL) in adults and children. Dr Advani guides us in the biology and genetics of the disease in these two categories of patients, dedicating a special focus to Philadelphia-like ALL and to the clinical and prognostic role of measurable residual disease (MRD). Finally, as CAR-T therapies are bec...

In this podcast, Dr Nemeth reminds us that iron is not only necessary for hematopoiesis and red cell production. A complex relationship exists between iron levels and susceptibility to infections, which involves the different sensibility of microbes to iron as well as the association between iron deficiency and poor response to immunization, as you will discover in this clear overview on the role...

This podcast series brings together people affected by SCD and specialist hematologists to shed light on this widely misunderstood condition, bringing the guidelines to life and helping healthcare professionals improve their practice by understanding the patient experience. In this first episode, consultant hematologist Dr Jo Howard has a conversation with two individuals affected by sickle cell d...