eCritCare Podcast

In this episode, we talk about the novel concept called mechanical power in ventilating patients with ARDS. This concept has led to a new debate as to whether we should move away from the dogmatic approach of fixed tidal volume ventilation to an individualised ventilation strategy for patients with ARDS. 

In this episode, we discuss the recently published landmark RCT -TTM2. This trial has answered the important question and forced us to reconsider our management practices around post-out of hospital cardiac arrest management. 

The recent study published by Golligher et al have challenged the dogma of setting 6-8 ml/kg Vt for all patients with ARDS. In this study, the authors demonstrated that the mortality in ARDS is related to driving pressure and baseline elastance and there is no correlation between mortality and plateau pressure or P/F ratio. In this episode, we discuss how this study will impact the future of mecha...

Oxygen is a precious commodity. COVID-19 pandemic has reminded us of the significance of Oxygen and we need to be mindful that Oxygen is a drug. It has its own side effects and thus warrants cautious use. In this podcast, we discuss controversial but thought-provoking COAST trial in-depth.  

COVID-19 pandemic continues to be a major problem across the globe. Various treatment options are emerging and we are desperate to achieve some normalcy in our lives. The recent addition is the use of monoclonal antibodies, which constitute a form of passive immunotherapy. In this podcast, we dive deeper into the available evidence on this novel treatment option.

Recently published RCTs and various guidelines have given us conflicting results w.r.t optimal dose of thromboprophylaxis in patients with COVID-19. In this episode, we dive deeper into the available evidence on this topic and suggest the rational approach in selecting the dose of thromboprophylaxis in COVID-19 patients.

Different Vaccines were developed during the COVID-19 pandemic at unprecedented speed using different platforms. However, recent reports raised concerns regarding thrombotic complications and thrombocytopenia after certain vaccines. In this episode, we discuss the pathophysiology and the treatment of this newly described syndrome.

In this episode, we discuss another landmark trial that has answered the very relevant question regarding the use of anti-fibrinolytic treatment in subarachnoid hemorrhage.

The use of neuromuscular blockade is not uncommon however, it's associated with many complications such as the increased risk of ICU acquired weakness, prolonged length of ICU stay along with the increased risk of corneal ulceration and VTE. In this episode, we discuss various indications for the use of NMB agents in ICU and review the available evidence on this topic.

Restrictive Vs Liberal transfusion strategy debate has come to the surface after the publication of the REALITY trial. In this podcast, we dive deeper into proposed transfusion thresholds in intensive care in various subgroups and the evidence behind them. 

Hemoglobin targets in patients with myocardial infarction are still debatable. In this episode, we discuss the landmark REALITY trial, which explores the non-inferiority of a restrictive transfusion strategy over a liberal transfusion strategy.

In this episode, we discuss recently published practice-changing trials RECOVERY and REMAP-CAP. These trials have clearly demonstrated the difference in mortality with the use of Tocilizumab in severe COVID-19.  

Join us to dive deeper into the recent controversy around oxygen therapy and its proposed targets in ICU patients. In this episode, we compare 3 landmark trials namely ICU-ROX, LOCO2 and  HOT-ICU along with recently published meta-analyses to fully understand the nature of this controversy and discuss our recommendations for the future. 

In this podcast, we discuss the challenges and the evidence behind different technological platforms used to produce COVID-19 vaccines. 

The year 2020 has been a challenging year for most of us. We all are eagerly waiting to get out of this pandemic. Recently published trial on COVID-19 vaccine has offered some hope, however its too soon to predict the outcome.

High lactate levels are uniformly associated with poor clinical outcomes, including mortality. However, there is considerable interest and conflict of opinion regarding the clinical value of using lactate levels to guide resuscitation in critically ill patients. In this episode, we dive deeper into this long-standing controversy. 

Join us in this episode, where we discuss the recently published trial in JAMA. This trial explores the efficacy of regional citrate anticoagulation over systemic heparin anticoagulation for CRRT. This is the largest randomised controlled trial on this topic and has provided very valuable answers on this topic.

In this episode, we discuss some of the controversial recommendations from surviving sepsis guidelines and talk about the rational approach in adopting these guidelines.

In this episode, we discuss what the importance of guidelines is, how they are formed and what does GRADE methodology involve. 

In this episode, we dive deeper to understand how to interpret a meta-analysis, which is usually situated at the top of the pyramid of Evidence-based medicine.

In this podcast, we discuss how one should interpret an RCT, which is considered as the gold standard while practising evidence-based medicine.

The role of steroids in COVID-19 has been endorsed after the publication of RECOVERY trial. However,  whether we should change our practices based on just one trial was heavily debated. In this podcast, we discuss the role of steroid in COVID-19 in-depth and weigh all the available evidence on this topic.

Prone positioning was first proposed in the 1970s as a method to improve gas exchange in ARDS. Subsequent observations of dramatic improvement in oxygenation with simple patient rotation motivated the next several decades of research. During COVID -19 pandemic, the debate on the utility of proning has been resurfaced. In this podcast, we dive deeper to discuss the physiology and evidence behind th...

In this podcast, we discuss a recently published landmark trial START-AKI trial. This trial explores the benefit of accelerated renal replacement strategy compared to standard strategy.

Join us in our Golden jubilee episode, where we discuss top 10 trials published in last two decades that helped to change the practices in Intensive care.