Dr RR Baliga's "Got Knowledge Doc" Podkast

🧪 Can we turn back the clock? A new RCT shows TPE + IVIG reversed biological age by 2.6 years in older adults! 🔄🧬 ✅ Boosted naïve T cells ⚠️ Small sample, no clinical endpoints 🔍 Personalized markers predict response #Aging #LongevityScience #Epigenetics 🧓📉✨

🥗 New study in Nature Food : Greater diversity of flavonoid intake—not just quantity—linked to ↓ risk of death, diabetes, heart disease & more 🌈🍇🍵   Eat the rainbow daily: apples, tea, berries, citrus, greens = longevity boost 💪🧬   #Nutrition #Longevity #Flavonoids

Marcus Aurelius (121–180 CE), a Roman emperor and prominent Stoic philosopher, ruled from 161 to 180 CE. As the last of the Five Good Emperors, his reign marked the end of the Pax Romana, a period of relative peace in the Roman Empire. Known for his military campaigns against Parthians and Germanic tribes, he also endured the devastating Antonine Plague. His philosophical reflections, compiled in ...

🩸 New JCI study reveals how RBC-derived EVs 🧬 in #Type2Diabetes sneak into endothelial cells 🧫, delivering arginase-1 & sparking oxidative stress 🔥—a hidden cause of vascular dysfunction.   Blocking EV uptake = 💡 new therapy?   📖 https://doi.org/10.1172/JCI180900 #CardioTwitter #Diabetes #VascularBiology

Big shift in Alzheimer's care! We can now predict it years in advance using 🩸 biomarkers like p-tau217, 🧬 genetic risk, & 🤖 AI-analyzed retina scans. Prevention = lifestyle 🥦🏃‍♂️💤, vaccines 💉, & maybe GLP-1s 💊. Why wait to treat when you can PREVENT? 🔍 #Alzheimers #PrecisionMedicine #AI

🧬 Did you know your blood cell metabolism could fuel heart disease? 🔁 Disrupted haematometabolism = more inflammation, less cleanup 🧹 Efferocytosis fails → plaques grow 🧠 Aging + CHIP mutations = 🔥 risk 🥗 Fix it with fasting, fitness & future therapies! #CardioTwitter #MedEd #Haematometabolism ❤️

🧬 The microbiome is medicine's next frontier! From Fecal Transplants 💩 to probiotics 🦠, diagnostics 🔍 to designer bugs 🧪—we're decoding disease, predicting treatment, and redefining care. But challenges remain. 🎙️ Dive into the FAQs with Got Knowledge Doc! #Microbiome #GutHealth #MedTwitter 🚀

📢 New from the SOUL trial! 💊 Oral semaglutide cuts heart attack risk in T2DM 🫀 but shows no benefit for stroke 🧠 or kidney disease 🧫. A win for adherence, a push for CKM integration! 🔄💡 #Diabetes #Cardiology #NEJM #CKM #GLP1RA @doximity

🏌️‍♂️⛳ Living near golf courses may increase Parkinson's risk! 📊 Case-control study: Risk highest within 1–3 miles 💧 Contaminated groundwater & pesticides likely culprits 🧠 aOR up to 2.98 for 6 miles! 📉 Risk ↓ 13% per mile after 3 miles 🔗 [JAMA 2025] #Neurology #Parkinsons #EnvironmentalHealth #GolfRisk @doximity

🚨 BREAKING: Sotatercept cuts risk by 76% in advanced #PAH! 💉 Targets activin signaling 🫁 Fewer deaths, transplants & hospitalizations 📉 HR 0.24 | Trial stopped early for efficacy ⚠️ Epistaxis, ↑Hgb, telangiectasia noted 🔬 A new era in pulmonary hypertension care! #ZENITHTrial #CardioTwitter 🫀📊 @doximity

🚨New COPD diagnosis alert!🫁 A multidimensional schema using CT 🖼️ + symptoms 😮‍💨 + spirometry 📉 identified high-risk patients missed by GOLD! 📈↑Mortality (HR 1.98) 📉FEV1 decline (–7.7 mL/y) 📊 Reclassified 15% w/o obstruction as COPD! 👉CT matters. #PulmTwitter #COPD #MedTwitter @doximity

🚨 New data! In the KARDIA-2 trial, 🧬 zilebesiran—an RNAi therapeutic—cut SBP by up to 12 mmHg when added to common antihypertensives 💊. One shot, 6 months of BP control! 📉 Promising for poor adherence. Mild AEs. #Hypertension #Cardiology #RNAi 🌍【JAMA 2025】 

🧬 Big win for longevity! A Nature Aging study shows that combining 💊 trametinib + rapamycin extends lifespan, reduces tumors, and tames inflammation in mice 🐭🔥 Dual geroprotectors = additive benefits without added toxicity 🛡️🕰️ Future of anti-aging? Watch this space 👀 #Aging #Longevity #Geroprotectors #Science 🧪 @doximity

🧠💉 New Lancet study (OPTIMISTmain) shows low-intensity monitoring after thrombolysis in mild strokes may be just as safe as standard care! 💤 Less sleep disruption, 🧑‍⚕️ lighter nursing load, ⚖️ similar outcomes. Could this change global stroke care? 🌍🏥 #Stroke #Thrombolysis #OPTIMISTmain #Neurology

🚨New A2B Trial in JAMA! Can 🧪dexmedetomidine or clonidine beat 💉propofol in sedating ICU patients on ventilators?   ❌ No faster extubation ⚠️ More bradycardia & agitation ⚖️ Similar mortality   Verdict: No clear winner—tailor sedation to patient needs 🛌👨‍⚕️ #CriticalCare #ICU #SedationTrial

🚨🧠 BREAKING: Tenecteplase before thrombectomy boosts chances of stroke recovery! 💉 Faster reperfusion 📈 Higher functional independence (mRS 0–2 at 90d: 52.9% vs 44.1%) ⚠️ Slight ↑ in sICH, but no major safety red flags 🧪 #BRIDGE_TNK trial rewrites the stroke playbook! #Stroke #Tenecteplase #NeuroTwitter

Nāgārjuna (c. 150 – c. 250 CE) was an Indian Buddhist monk and philosopher, regarded as the founder of the Madhyamaka (Middle Way) school of Mahāyāna Buddhism. His most famous work,  Mūlamadhyamakakārikā (Root Verses on the Middle Way), presents the concept of śūnyatā (emptiness) and the two truths doctrine, emphasizing dependent origination and rejecting inherent existence. Nāgārjuna's philosophy...

📢 New RCT in Nature Medicine 🎯 Can zapping low-voltage areas (LVAs) reduce AF recurrence after PVI?   🔬 SUPPRESS-AF Trial 👥 342 pts with persistent AF 📉 1-yr AF/AT-free: 61% (PVI+LVA) vs 50% (PVI) ❌ Not statistically significant 🧠 Subgroup benefit in high-risk pts   #EPeeps #AFib #CardioTwitter 🫀

🧠💪 Can blood biomarkers of Alzheimer's predict who'll lose muscle strength with age?   In a 12-year study, higher p-tau, NfL & GFAP levels forecasted faster decline in grip & leg power — even before dementia onset.   🧬🪑✊ #Aging #Alzheimers #Sarcopenia #Biomarkers #Longevity

📉 New JAMA study tracks U.S. #SedentaryBehavior from 2013–2023: 🪑 Sitting time fell from 7.1 to 5.9 hrs/day pre-COVID 🦠 But plateaued post-pandemic at 6.0 hrs/day 🚶‍♀️ Progress stalled—time to get moving again! #PublicHealth #NHANES #PhysicalActivity 🏃‍♂️📊🛋️

🐒 New study finds no disorganized attachment in wild chimpanzees! 🧠 Only secure & avoidant types observed—just like humans, but without the trauma. 🌿 Evolution favors calm, connected bonds. 📍Taï National Park, Côte d'Ivoire 🔗 Nature knows best. #PrimateScience #AttachmentTheory #Chimpanzees

💡World's tiniest pacemaker—smaller than a grain of rice! 🫀Leadless, wireless & bioresorbable 🔦 Powered by NIR light 🧬 Perfect for post-op pacing & TAVR 🌱 No wires, no scars, no removal! #MedTech #Cardiology #Bioengineering #Innovation @Nature

Cutting cysteine = 🔥 30% weight loss in 7 days! 🧬 Triggers stress pathways (ISR/OSR) ❌ CoA & glutathione drop 🔥 Browning fat, futile cycling, energy drain 💡 Reversible & promising for obesity research! #Metabolism #Obesity #AminoAcids #Science 🧪⚖️🧠

🚨 TAVI Trials Update! 🆚 COMPARE-TAVI 1 : 🇮🇳Myval = 💪SAPIEN 3 in safety & efficacy 🆚 ACURATE IDE : ACURATE neo2 ❌not non-inferior to 💥SAPIEN/EVOLUT 📊 Valve wars intensify! #TAVI #HeartValve #Cardiology 🫀

🌶️ Not all chili heat is created equal! Scientists found hidden compounds—like capsianoside I & roseoside—that cool the burn without changing flavor 🔬❄️ Your next spicy dish might be hot… but not hurt. #FlavorScience #Capsaicin #TRPV1 #FoodTech 🍽️🧠🔥