Dr RR Baliga's "Got Knowledge Doc" Podkast

Patanjali, an ancient Indian sage, is credited with authoring foundational texts in Sanskrit grammar ( Mahābhāṣya ), yoga philosophy ( Yoga Sutras ), and possibly medicine ( Patanjalatantra ). Revered as a mystic and philosopher, his works laid the groundwork for classical yoga and linguistics, profoundly influencing Indian philosophical traditions. Though scholarly debates persist about his ident...

🏃‍♂️💪 New NEJM study shows structured exercise after chemo boosts survival in colon cancer patients! 📈 5-yr DFS: 80.3% vs 73.9% ❤️ 8-yr OS: 90.3% vs 83.2% 🧬 Fitness = longevity 👟 Time to prescribe steps, not just scripts? #Oncology #ExerciseIsMedicine #CHALLENGEtrial

🚨 New trial alert! In youth with type 1 diabetes, adding #SGLT2i 💊 (dapagliflozin) to insulin: ✅ Reduced glomerular hyperfiltration ✅ Lowered HbA1c 📉 ✅ Boosted time-in-range ⏱️ 😌 Safe with DKA precautions in place 📄 #ATTEMPTTrial | @NatureMedicine 🔗 https://doi.org/10.1038/s41591-025-03723-6

📉 New study alert!   Patients with diabetes using GLP-1 receptor agonists had 2x higher risk of developing neovascular macular degeneration 😮   Longer use = greater risk 📈   Clinicians, keep an 👀 on ocular safety! #GLP1 #Diabetes #EyeHealth #nAMD #JAMAOphthalmology

🧲 New twist in sex determination! Maternal iron levels shape whether XY embryos become male 🧬👶. Low iron ➡️ silenced Sry gene ➡️ female development 💡🧪. Epigenetics meets nutrition in utero—stay iron-clad, moms!   #Epigenetics #IronMatters #SexDetermination

🔬 New in @ScienceMagazine: Researchers grew mini human organs (gastruloids) with real blood vessels! ❤️🧠 Using stem cells + special cocktails, they modeled early heart & liver development in a dish. A leap for organoids & regenerative medicine! 🧪🧬 #Biotech #StemCells #Organoids

🧬 Is taurine the secret to youth? Not quite. 📈 New study shows taurine levels 📈 with age—especially in women. 🙅‍♂️ Not a reliable aging biomarker: too much variability, too many mixed signals. 🧠 Context matters. Supplement wisely. #Longevity #AgingResearch #Taurine #Science 🧪

🧬 New vascular villain? It's not always clots. 💥 Necroptosis of endothelial cells triggers red blood cell rupture. 🩸 Sticky RBC fragments form "endo-seals" that block blood flow—especially in COVID-19, stroke, and MI. 🎯 Targets? Think MLKL & complement, not just platelets. #MedTwitter #COVID19 #VascularBiology #Pathology

🧬 New study reveals 4 stable #Immunotypes in healthy adults! Each with unique 🔥inflammatory, 🦠CMV-driven, 💧quiet, or 🔥aging-linked immune traits. They predict LPS response better than age or sex. Welcome to the era of immune fingerprinting! 🧪🧠 #PrecisionMedicine #Immunology #Multiomics

🥖 Not all carbs are created equal — or digested the same! A new study shows glycemic responses vary wildly by individual 🍚🥔🍞🍇 Your microbiome, metabolism, and ethnicity all matter! Precision nutrition is the future 🔬🧬📊 #GlycemicResponse #CGM #NutritionScience #T2D 🍽️

🧬 A new epigenetic clock predicts your functional age — not just birthdays! 🕰️ Built from 91 CpGs, the IC Clock outperforms GrimAge & others at predicting mortality 💪 Linked to T-cell health, 🫁 lung function & 🐟 omega-3 intake 📖 Nature Aging: https://doi.org/10.1038/s43587-025-00883-5 #Aging #Epigenetics #Longevity #Immunosenescence Doximity

🥜 Daily almonds = big wins for metabolic health! ✅ ↓ LDL & total cholesterol ✅ ↑ Vitamin E (α-tocopherol) ✅ ↓ Gut inflammation (calprotectin, MPO) ❌ No change in systemic inflammation or weight Crunch wisely, live heart-smart! ❤️🧠 #Nutrition #MetabolicSyndrome #RCT #Almonds #GutHealth

🧪 Can we turn back the clock? A new RCT shows TPE + IVIG reversed biological age by 2.6 years in older adults! 🔄🧬 ✅ Boosted naïve T cells ⚠️ Small sample, no clinical endpoints 🔍 Personalized markers predict response #Aging #LongevityScience #Epigenetics 🧓📉✨

🥗 New study in Nature Food : Greater diversity of flavonoid intake—not just quantity—linked to ↓ risk of death, diabetes, heart disease & more 🌈🍇🍵   Eat the rainbow daily: apples, tea, berries, citrus, greens = longevity boost 💪🧬   #Nutrition #Longevity #Flavonoids

Marcus Aurelius (121–180 CE), a Roman emperor and prominent Stoic philosopher, ruled from 161 to 180 CE. As the last of the Five Good Emperors, his reign marked the end of the Pax Romana, a period of relative peace in the Roman Empire. Known for his military campaigns against Parthians and Germanic tribes, he also endured the devastating Antonine Plague. His philosophical reflections, compiled in ...

🩸 New JCI study reveals how RBC-derived EVs 🧬 in #Type2Diabetes sneak into endothelial cells 🧫, delivering arginase-1 & sparking oxidative stress 🔥—a hidden cause of vascular dysfunction.   Blocking EV uptake = 💡 new therapy?   📖 https://doi.org/10.1172/JCI180900 #CardioTwitter #Diabetes #VascularBiology

Big shift in Alzheimer's care! We can now predict it years in advance using 🩸 biomarkers like p-tau217, 🧬 genetic risk, & 🤖 AI-analyzed retina scans. Prevention = lifestyle 🥦🏃‍♂️💤, vaccines 💉, & maybe GLP-1s 💊. Why wait to treat when you can PREVENT? 🔍 #Alzheimers #PrecisionMedicine #AI

🧬 Did you know your blood cell metabolism could fuel heart disease? 🔁 Disrupted haematometabolism = more inflammation, less cleanup 🧹 Efferocytosis fails → plaques grow 🧠 Aging + CHIP mutations = 🔥 risk 🥗 Fix it with fasting, fitness & future therapies! #CardioTwitter #MedEd #Haematometabolism ❤️

🧬 The microbiome is medicine's next frontier! From Fecal Transplants 💩 to probiotics 🦠, diagnostics 🔍 to designer bugs 🧪—we're decoding disease, predicting treatment, and redefining care. But challenges remain. 🎙️ Dive into the FAQs with Got Knowledge Doc! #Microbiome #GutHealth #MedTwitter 🚀

📢 New from the SOUL trial! 💊 Oral semaglutide cuts heart attack risk in T2DM 🫀 but shows no benefit for stroke 🧠 or kidney disease 🧫. A win for adherence, a push for CKM integration! 🔄💡 #Diabetes #Cardiology #NEJM #CKM #GLP1RA @doximity

🏌️‍♂️⛳ Living near golf courses may increase Parkinson's risk! 📊 Case-control study: Risk highest within 1–3 miles 💧 Contaminated groundwater & pesticides likely culprits 🧠 aOR up to 2.98 for 6 miles! 📉 Risk ↓ 13% per mile after 3 miles 🔗 [JAMA 2025] #Neurology #Parkinsons #EnvironmentalHealth #GolfRisk @doximity

🚨 BREAKING: Sotatercept cuts risk by 76% in advanced #PAH! 💉 Targets activin signaling 🫁 Fewer deaths, transplants & hospitalizations 📉 HR 0.24 | Trial stopped early for efficacy ⚠️ Epistaxis, ↑Hgb, telangiectasia noted 🔬 A new era in pulmonary hypertension care! #ZENITHTrial #CardioTwitter 🫀📊 @doximity

🚨New COPD diagnosis alert!🫁 A multidimensional schema using CT 🖼️ + symptoms 😮‍💨 + spirometry 📉 identified high-risk patients missed by GOLD! 📈↑Mortality (HR 1.98) 📉FEV1 decline (–7.7 mL/y) 📊 Reclassified 15% w/o obstruction as COPD! 👉CT matters. #PulmTwitter #COPD #MedTwitter @doximity

🚨 New data! In the KARDIA-2 trial, 🧬 zilebesiran—an RNAi therapeutic—cut SBP by up to 12 mmHg when added to common antihypertensives 💊. One shot, 6 months of BP control! 📉 Promising for poor adherence. Mild AEs. #Hypertension #Cardiology #RNAi 🌍【JAMA 2025】 

🧬 Big win for longevity! A Nature Aging study shows that combining 💊 trametinib + rapamycin extends lifespan, reduces tumors, and tames inflammation in mice 🐭🔥 Dual geroprotectors = additive benefits without added toxicity 🛡️🕰️ Future of anti-aging? Watch this space 👀 #Aging #Longevity #Geroprotectors #Science 🧪 @doximity