Discovery

Many people are living with chronic diseases such as rheumatoid arthritis and inflammatory bowel conditions in which the body attacks itself. Although drug treatments have improved over recent years they do not work for everyone and can have serious side effects. Now researchers such as neurologist Dr Kevin Tracey of the Feinstein Institute for Medical Research, and rheumatologist professor Paul-P...

Jim al-Khalili talks to professor Elspeth Garman about a technique that has led to 28 Nobel Prizes in the last century. X- ray crystallography, now celebrating its 100th anniversary, is used to study the internal structure of matter. It may sound rather arcane but it is the reason we now know the structure of hugely important molecules, like penicillin, insulin and DNA. But while other scientists...

Addictions researcher, Dr Sally Marlow, investigates fears that easy access to powerful painkillers could be creating a large, but hidden problem of addiction. Painkillers are widely available over the counter, and combinations containing codeine, which is addictive, can be purchased from pharmacists and on the internet. Teenager, Alice, tells Sally about secretly buying huge numbers of painkiller...

European Inventor of the Year, Chris Toumazou, reveals how his personal life and early research lie at the heart of his inventions. As chief scientist at the Institute of Biomedical Engineering at Imperial College London, Chris inspires engineers, doctors and other scientists to create medical devices for the 21st Century. Applying silicon chip technology, more commonly found inside mobile phones,...

It is the nearest and most dominant object in our night sky, and has inspired artists, astronauts and astronomers. But fundamental questions remain about our only natural satellite. Where does the Moon come from? Although humans first walked on the Moon over four decades ago, we still know surprisingly little about the lunar body's origin. Samples returned by the Apollo missions have somewhat conf...

They call them 'The Unexpected Survivors'. The casualties from the war in Afghanistan whose injuries were so severe that they were not expected to survive, but who survived nevertheless. In October, after 13 years Britain and the United States officially brought their combat operations in Helmand Afghanistan to an end. Camp Bastion, the coalition stronghold – once one of the largest military bases...

Dr Kevin Fong explores the development of modern trauma medicine and discovers how the lessons from conflict and catastrophe have equipped us to deal with even the worst disasters, providing a system that could save lives that would otherwise have been lost. First of two programmes.

Professor Brian Cox of Manchester University describes how he gave up appearing on Top of the Pops to study quarks, quasars and quantum mechanics. Although he describes himself as a simple-minded Northern bloke, he has acquired an almost God-like status on our TV screens, while the ‘Cox effect’ is thought to explain the significant boost to university admissions to read physics. He talks to Jim al...

You have a headache and take a pill. The headache is gone, but what about the pill? What we flush away makes its way through sewers, treatment works, rivers and streams and finally back to your tap. Along the way most of the drugs we take are removed but the tiny amounts that remain are having effects. Feminised fish in our rivers, starlings feeding on Prozac-rich worms, and bacteria developing an...

Patient power is on the rise. But is it rising too far? Frustrated by the time it takes to develop new drugs, the ethical barriers to obtaining clinical data or the indifference of the medical profession to obscure diseases, patients are setting up their own clinical trials and overturning the norms of clinical research. A DIY clinical trial sounds like a joke – and a dangerous one at that. But as...

Diseases devastate livestock around the world. In chickens for example the deadly strain of bird flu and the lesser known bacterial infection Campylobacter, not only harms the chickens but is also a real threat to human health. Melissa Hogenboom visits one of the world’s leading genetics institutions, the Roslin Institute in Edinburgh in the UK and hears about new genetic techniques to combat dise...

Rebecca Morelle talks to explorers of deep ocean trenches, from film-maker James Cameron to biologists discovering dark realms of weird pink gelatinous fish and gigantic crustaceans. The deepest regions of the ocean lie between 6,000 and 11,000 metres. Oceanographers term this the Hadal Zone. It exists where the floor of abyss plunges into long trough-like features, known as ocean trenches. The Ha...

Gaia Vince looks at the future of power transmission. As power generation becomes increasingly mixed and demand increases, what does the grid of the future look like?

Accidents happen in science labs all over the world, but when you’re working with deadly pathogens the consequences can be disastrous. The reputation of America’s ‘gold standard’ The Centres for Disease Control and Prevention in Georgia has recently become tarnished as news emerged that 80 workers were inadvertently exposed to live anthrax, and a deadly strain of flu was accidentally sent to anoth...

Alana Saarinen is a 13-year-old girl who lives with her mum and dad in Michigan, USA. She loves playing golf and the piano, listening to music and hanging out with friends. In those respects, she's like many teenagers around the world. Except she's not, because Alana is one of a handful of people in the world who have DNA from three people. The BBC's Science Correspondent Rebecca Morelle explores...

Infectious bacteria are becoming resistant to the drugs that used to kill them. The last new class of antibiotics was discovered in the 1980s. There is little in the development pipelines of the world’s pharmaceutical industry. Drug companies got out of antibiotics as their attention switched to much more lucrative daily medicines for chronic diseases. Public funding on antibiotic research has als...

The discovery and harnessing of antibiotic drugs in the mid-20th Century led some medics to predict the end of infectious diseases. But the bacteria fought and continue to fight back, evolving resistance to many of the drugs that used to kill them. Public health officials warn that without new drugs, medicine will return to the days where ‘a cut finger on Monday leads to death of Friday’. Without...

In March astronomers in the BICEP2 collaboration announced they had found gravitational waves from the Big Bang. But now the evidence is being questioned by other scientists. Dr Lucie Green reports on the debate and asks if scientists can ever know what happened billions of years ago when the universe was formed. Image copyright: Steffen Richter, Harvard University

On 6th August, the space probe Rosetta ends its 10 year journey and arrives at Comet 67P/Churyumov-Gerasimenko. If all goes well, Rosetta will be the first spacecraft to go into orbit around a comet. The European Space Agency probe will then accompany the comet until December 2015, studying the 4 kilometre-wide lump of ice and rock dust at a level of detail far surpassing any previous comet flyby....

Professor Sir Michael Rutter has been described as the most illustrious and influential psychiatric scientist of his generation. His international reputation has been achieved despite the fact that as a young doctor, he had no intention of becoming a researcher, nor interest in becoming a child psychiatrist. In fact he became a world leader as both. His career has spanned more than five decades an...

At the start of 2014 meteorologists warned of a possible El Nino event this year. The portents were persuasive – a warming of the central Pacific much like that which preceded the powerful El Nino event of 1997. But since then the Pacific climate system seems to have stalled. What’s going on? What are the prospects for an El Nino to develop later this year? What impacts might it have? Roland Pease...

Adam Hart looks at how new developments in understanding insect behaviour, plant cell growth and sub cellular organisation are influencing research into developing robot swarms. Biological systems have evolved elegant ways for large numbers of autonomous agents to govern themselves. Staggering colonies built by ants and termites emerge from a decentralized, self-governing system: swarm intelligenc...

General anaesthetics which act to cause reversible loss of consciousness have been used clinically for over 150 years. Yet scientists are only now really understanding how these drugs act on the brain and the body to stop us feeling pain. Linda Geddes reports on the latest research using molecular techniques and brain scanners. Linda visits the Anaesthesia Heritage Centre where William Harrop-Grif...

Janet Hemingway, the youngest woman to ever to become a full professor in the UK, talks about her career at the frontline of the war on malaria. Whilst many researchers look for vaccines and treatments to this global killer, Janet's approach, as a trained entomologist, has been to fight the mosquito - the vector - which transmits the malaria parasite. Image: Janet Hemingway, BBC Copyright

Geoff Watts investigates the latest thinking about our brain power in old age. He meets researchers who argue that society has overly negative views of the mental abilities of the elderly - a dismal and fatalistic outlook which is not backed up by recent discoveries and theories. Geoff talks to professor Lorraine Tyler who leads a large study in Cambridge (CamCAN) which is comparing cognition and...