Digital Pathology Podcast

Send us Fan Mail Deep learning artificial intelligence has entered the field of digital pathology and is here to stay because it consistently outperforms the classical image analysis methods on pathology slides. The only caveat is that to train good deep learning image analysis models we need a lot of whole slide images. Where do we get them? Is there a central repository that can be used for this...

Send us Fan Mail Digital pathology is supposed to help pathologists provide better patient care and make their lives easier, but what about other doctors, do they even care? Maybe radiologists? Oncologists? Nope… Dermatologists! They do care! And they are the clients of Pathology Watch – a CLIA lab specializing in dermatopathology, that is currently servicing samples from over 65 dermatology clini...

Send us Fan Mail A common misconception about digital pathology is that it is synonymous with whole slide imaging and has a high price point. This is not the case, as one can enter the digital pathology world and benefit from what it has to offer with a simple microscope camera. If we would like a more sophisticated solution, but don't want to get a whole slide scanner or don't have the...

Send us Fan Mail This episode is brought to you by Visiopharm .  With the regulatory approvals of whole slide imaging systems, digital pathology became the modality for routine diagnostics. Digitalization of pathology is aiming at increasing precision and productivity in the pathology lab, but the adoption of this field is slower than expected.  One of the causes of the slow adoption is that going...

Send us Fan Mail Visiopharm is a company offering image analysis software used on pathology images. The software has been on the market for over 20 years and has evolved through the transition of digital microscopy to digital pathology. Digital microscopy provided static tissue images captured through the microscope camera and only branched out into digital pathology with the wider availability an...

Send us Fan Mail Even though tissues are tridimensional structures, most tissue research is done on two-dimensional tissue slides. This leaves a tremendous amount of biological information on the table. This episodes' guest - Sharla White, Ph. D., the vice president of research and development at ClearLight Biotechnologies explains how tissue clearing and 3D immunofluorescence can take your t...

Send us Fan Mail The Digital Imaging and Communications in Medicine (DICOM) standard for digital medical imaging has been around since the 1980s . First adopted in radiology it is slowly spreading in pathology as well. Now with image analysis being an integral part of medical imaging workflows, the question arose if the annotations made on the images should have a standard format as well? And can...

Send us Fan Mail In the world of anatomic digital pathology, the mention of digital cytology usually causes thoughts of all the challenges associated with it. We are often not aware that digital pathology and image analysis applications started with digital hematology and cytology (e.g. image analysis-based pap smear evaluation) and that in veterinary medicine digital cytology is a booming discipl...

Send us Fan Mail In this episode, we talk with Heather Couture about how to make deep learning models for tissue image analysis more robust to domain shift. Supervised deep learning has made a strong mark in the histopathology image analysis space, however, this is a data-centric approach. We train the image analysis solution on whole slide images and want them to perform on other whole slide imag...

Send us Fan Mail Advanced computer science expertise with the ability to code and a medical degree with over 20 years of clinical experience is a rare combination. This episode’s guest, Martin Weihrauch MD , the co-founder of Smart in Media incorporates this rare combination.  His digital pathology platform originated when he was asked by a pharmaceutical company to provide some interactive entert...

Send us Fan Mail What do cancer and climate change have in common? Both are very serious problems and in both, machine learning (ML) and artificial intelligence (AI) can be used to support potential solutions. Even though these AI applications may seem very different the ML methods used to support work on both problems are very similar.  Today’s episode’s guest, Heather Couture from Pixel Scientia...

Send us Fan Mail AI-powered algorithms for digital pathology and tissue image analysis are not new, also digital cytology and hematology already have their share of AI algorithms helping pathologists with faster and more accurate diagnoses. But what about parasitology or microbiology? Techcyte has a tool for that as well.   Today my podcast guest is Ben Cahoon, the CEO of Techcyte, a software star...

Send us Fan Mail This episode contains affiliate links. Learn what that means here Have you ever tried to take a picture through your microscope with your smartphone? If you have, you know how much hassle it is to consistently take good, sharp microscope pictures. So maybe, annoyed with how cumbersome it is and how much time it takes, you have already looked for a microscope phone adapter? I know...

Send us Fan Mail How many times did you get annoyed when using non-intuitive digital pathology software? Have you already given up on digital pathology and image analysis or are you still looking for something powerful but easy to use?  Today’s guest, Tuomas Ropponen, the chief technology officer at Aiforia, is talking about the creation of a pathology image analysis platform whose core principles...

Send us Fan Mail With more than 170K total downloads and over 700 citations in scientific literature, QuPath is arguably the most popular open-source software for quantitative pathology and bioimage analysis. Today’s podcast guest, Pete Bankhead , the author of QuPath , is taking us behind the scenes of his software creation. Even though Pete is now a senior lecturer in digital pathology at the Un...

Send us Fan Mail This episode is brought to you by Visiopharm Cancer immunotherapy, aka immuno-oncology, is tapping into the power of our own immune system to fight cancer. There are multiple processes and immune cell populations involved in tumor immunology and digital pathology and whole slide imaging has allowed scientists to leverage the power of tissue image analysis to detect and quantify th...

Send us Fan Mail Are you looking for a whole slide scanner for your digital pathology projects? In this podcast episode Doug Stapleton, the Service Manager of the digital slide scanner division of Hamamatsu , is guiding us through this process.   He is listing 10 questions you need to ask before purchasing a whole slide scanner tailored to your digital pathology needs. Question 1: What is your bud...

Send us Fan Mail Have you ever wondered if the pathology turn-around time could be faster and came to the conclusion that the only way to achieve that is to skip the tissue sectioning and staining? Now it is possible, with optical scanning microscopy by Instapath.  Today’s guest, David Tulman, is the chief clinical officer of Instapath, a small startup using optical scanning microscopy to image fr...

Send us Fan Mail This episode is brought to you by Visiopharm. In this third and last episode of the multiplex mini-series with Regan Baird from Visiopharm we look at the considerations when choosing an image analysis software for phenotyping. The two main points to consider when choosing phenotyping image analysis software are segmentation assistance and data visualization.   Segmentation assista...

Send us Fan Mail This episode is brought to you by Visiopharm. Multiplex tissue staining can generate large amounts of data to help identify distinct information about particular cells in tissue.  Immuno-oncology is a field where it is common practice to use multiplexing, in particular for cell phenotyping in tissue. Phenotyping is the ability to classify every individual cell in the tissue based...

Send us Fan Mail Founded in 2011 by this episode’s guest, Lorcan Sherry, along with co-founder John Waller, OracleBio entered the digital pathology market with a unique value proposition – to be a contract research organization for tissue image analysis and help other organizations in their biomarker discovery work.  Fast forward 10 years and they evolved from a small service provider into a Good...

Send us Fan Mail This episode is brought to you by Visiopharm. After experimenting with multidimensional, multimarker, and multicolor single-cell imaging modalities during his postdoc at Beth Israel Deaconess Medical Center in Boston, looking at 2D images of tissue stained just with hematoxylin and eosin (H&E) seemed to him a bit simplistic…and then he was tasked with doing tissue image analys...

Send us Fan Mail As a computer scientist, he knew that to make a real impact with image analysis there were only two areas: military and life sciences. Sylvain Berlemont, the founder of Keen Eye chose life sciences and never looked back. He started consulting for the industry during his biomedical image analysis research work in academia and he quickly saw that regardless of the applications, the...

Send us Fan Mail Smartphone, smartwatch, smart TV...internet of things (IoT) and artificial intelligence of things (AIoT) is ubiquitous. But did it already make it into any of the digital pathology devices? Oh yes! There is a smart whole slide scanner out there. In this episode, I am talking with Don Van Dyke, the chief business officer of Bionovation Biotech . Bionovation holds a patent to a pote...

Send us Fan Mail Medical tests and procedures can get reimbursed. The basis of the reimbursement are the Current Procedural Terminology (CPT) codes developed by the American Medical Association (AMA).  But how can such a code be obtained for digital pathology which is so much more complex than a group of tests or procedures that could be reimbursed on a fee-for-service basis? According to Esther A...